Publications 2020-2021

  • One-pot Diastereoselective Synthesis of Chiral Tricyclic L-Cysteine and D-penicillamine Derivatives: A Laboratory Experiment, Maria I. L. Soares, Susana M. M. Lopes, Teresa M. V. D. Pinho e Melo, Química Nova 2020,43, 123-126 [http://dx.doi.org/10.21577/0100-4042.20170448].
  • Spiro-Lactams as Novel Antimicrobial Agents, Américo J. S. Alves, Nuno G. Alves, Cátia C. Caratão, Margarida I. M. Esteves, Diana Fontinha, Inês Bártolo, Maria I. L. Soares, Susana M. M. Lopes, Miguel Prudêncio, Nuno Taveira, Teresa M. V. D. Pinho e Melo, Curr. Top. Med. Chem. 2020, 20, 140-152 [DOI: 10.2174/1568026619666191105110049].
  • Asymmetric Neber Reaction in the Synthesis of Chiral 2-(Tetrazol-5-yl)-2H-Azirines, Cláudia Alves, Carla Grosso, Pedro Barrulas, José A. Paixão, Ana L. Cardoso, Anthony J. Burke, Américo Lemos Teresa M. V. D. Pinho e Melo, Synlett 2020,  31, 553-558 [DOI:10.1055/s-0039-1691533].
  • Platinum(II) Ring-Fused Chlorins as Efficient Theranostic Agents: Dyes for Tumor-Imaging and Photodynamic Therapy of Cancer, Mafalda Laranjo, Márcia Campos Aguiar, Nelson A. M. Pereira, Gonçalo Brites, Bruno F. O. Nascimento, Ana Brito, João Casalta-Lopes, Ana Cristina Gonçalves, Ana Bela Sarmento-Ribeiro, Marta Pineiro, Maria Filomena Botelho, Teresa M. V. D. Pinho e Melo, Eur. J. Med. Chem 2020, 200, 112468 [https://doi.org/10.1016/j.ejmech.2020.112468].
  • A Novel Bioanalytical Method for the Determination of Opioids in Blood and Pericardial Fluid, Elisa Ferreira, Francisco Corte Real, Teresa M. V. D. Pinho e Melo, Cláudia Margalho, Journal of Analytical Toxicology, 2020, 44, 754-768 [https://doi.org/10.1093/jat/bkaa064]
  • Corroles and Hexaphyrins: Synthesis and Application in Cancer Photodynamic Therapy, Susana M. M. Lopes, Marta Pineiro Teresa M. V. D. Pinho e Melo, Molecules 2020, 25, 3450 [doi:10.3390/molecules25153450].
  • Synthesis of Novel Chiral  spiroisoxazoline-β-lactams from 6-Alkylidenepenicillanates: A 1,3-Dipolar Cycloaddition Approach, Américo J. S. Alves, Teresa M. V. D. Pinho e Melo, Eur. J. Org. Chem. 2020, 6259-6269 [DOI: 10.1002/ejoc.202001085].
  • Novel spiro-β-lactam BSS-730A displays potent anti-HIV and anti-plasmodial activity, Inês Bártolo, Bruna S. Santos, Diana Fontinha, Marta Machado, Denise Francisco, Bruno Sepodes, João Rocha, Hélder Mota-Filipe, Rui Pinto, Maria E.Figueira, Helena Barroso, Teresa Nascimento, António P. Alves de Matos, Américo J. S. Alves, Nuno G. Alves, Carlos J.V. Simões, Miguel Prudêncio, Teresa M.V.D. Pinho e Melo,* Nuno Taveira,* ACS Infect. Dis. 2021, 7, 421-434 [https://dx.doi.org/10.1021/acsinfecdis.0c00768].
  • Reactivity of Steroidal 1-Azadienes Toward Enamines: An Approach to Novel Chiral Penta- and Hexacyclic Steroids, Susana M. M. Lopes, Joana R. C. Santos and Teresa M. V. D. Pinho e Melo, Org. Biomol. Chem.2021,19, 1122-1132 [https://doi.org/10.1039/D0OB02344B].
  • A New Selective P53 Activator and Anticancer Agent to Improve Colorectal Cancer Therapy, Helena Ramos, Maria Isabel Soares, Joana Silva, Liliana Raimundo, Célia Gomes, Flávio Reis, Filipe Monteiro, Cláudia Nunes, Salette Reis, Bartolomeo Bosco, Silvano Piazza, Lucília Domingues, Petr Chlapek, Renata Veselska, Alberto Inga, Teresa M.V.D. Pinho e Melo,* Lucília Saraiva* Cell Reports 2021, 35, 108982 (April 13 2021) [https://doi.org/10.1016/j.celrep.2021.108982].
  • Recent Advances in the Synthesis of Spiro-β-Lactams and Spiro-δ-Lactams, Nuno G. Alves, Américo J. S. Alves, Maria I. L. Soares, Teresa M. V. D. Pinho e Melo, Advanced Synthesis & Catalysis 2021,363, 2464-2601 [DOI: 10.1002/adsc.202100013].
  • Novel fluorinated ring-fused chlorins as promising PDT agents against melanoma and esophagus cancer, Nelson A. M. Pereira, Mafalda Laranjo, Bruno F. O. Nascimento, João C. S. Simões, João Pina, Bruna D. P. Costa, Gonçalo Brites, João Braz, J. Sérgio Seixas de Melo, Marta Piñeiro, Maria Filomena Botelho, Teresa M. V. D. Pinho e Melo, RSC Med. Chem. 2021, 12, 615-627 [DOI: 10.1039/d0md00433b].
  • Synthesis and Structure-Activity Relationships of New Chiral Spiro-β-lactams Highly Active Against HIV-1 and Plasmodium, Nuno Guerreiro Alves, Inês Bártolo, Américo J.S. Alves, Diana Fontinha, Denise Francisco, Susana M.M. Lopes, Maria I.L. Soares, Carlos J.V. Simões, Miguel Prudêncio, Nuno Taveira, Teresa M.V.D. Pinho e Melo, Eur. J. Med. Chem. 2021, 219, 113439 [https://doi.org/10.1016/j.ejmech.2021.113439].
  • Strategies and methodologies for the construction of spiro-γ-lactams: an update, Américo J. S. Alves, Nuno G. Alves, Maria I. L. Soares, Teresa M. V. D. Pinho e Melo, Organic Chemistry Frontiers 2021, 8, 3543-3593 [https://doi.org/10.1039/D0QO01564D].
  • Switching on H-tunneling through conformational control, José P. L. Roque, Cláudio M. Nunes, Luís P. Viegas, Nelson A. M. Pereira, Teresa M. D. V. Pinho e Melo, Peter R. Schreiner, Rui Fausto, J. Am. Chem. Soc.  2021, 143, 8266-8271  [https://doi.org/10.1021/jacs.1c04329].
  • One-pot Synthetic Approach to Dipyrromethanes and Bis(indolyl)methanes via Nitrosoalkene Chemistry, Ana L. Cardoso, Susana M. M. Lopes, Carla Grosso, Marta Pineiro, Américo Lemos, Teresa M. V. D. Pinho e Melo, J. Chem. Educ. 2021, 98, 2661-2666 [https://doi.org/10.1021/acs.jchemed.1c00184].
  • Reduction of Oximes and Hydrazones: Asymmetric and Diastereoselective Approaches, João L. P. Ribeiro, Claúdia Alves, Ana L. Cardoso, Susana M. M. Lopes, Teresa M. V. D. Pinho e Melo, Curr. Org. Chem. 2021, 25, 2175-2198 [DOI:10.2174/1385272825666210706151631].
  • Inducing molecular reactions by selective vibrational excitation of a remote antenna with near-infrared light, Cláudio M. Nunes, Nelson A. M. Pereira, Luís P. Viegas, Teresa M. V. D. Pinho e Melo, Rui Fausto, Chem. Commun. 2021, 57, 9570-9573 [DOI: 10.1039/d1cc03574f].
  • Synthesis of 5H-chromeno[3,4-b]pyridines via DABCO-catalyzed [3+3] annulation of 3-nitro-2H-chromenes and allenoates, Maria I. L. Soares, Clara S. B. Gomes, M. Conceição Oliveira, Joaquim Marçalo, Teresa M. V. D. Pinho e Melo, Org. Biomol. Chem. 2021, 19, 9711-9722 [DOI: 10.1039/d1ob01130h].
  • 2,4,6-Trinitro-N-(m-tolyl)aniline: A New Polymorphic Material Exhibiting Different Colors, Bernardo A. Nogueira, Susana M. M. Lopes, Susy Lopes, Timur Nikitin,  Ana Clara B. Rodrigues, Maria Ermelinda S. Eusébio, José A. Paixão, Teresa M. V. D. Pinho e Melo, Alberto Milani, Chiara Castiglioni, Rui Fausto, Cryst. Growth Des. 2021, 21, 7269-7284 [https://doi.org/10.1021/acs.cgd.1c01123]