Publications 2013-2014

Chiral 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles with anti-Breast Cancer Properties, Maria I. L. Soares, Ana Filipa Brito, Mafalda Laranjo, José A. Paixão, M. Filomena Botelho, Teresa M. V. D. Pinho e Melo, Eur. J. Med. Chem. 2013, 60, 254-262 [http://dx.doi.org/10.1016/j.ejmech.2012.11.036].

Thiazolo[3,4-b]indazole-2,2-dioxides as Masked Extended Dipoles: Pericyclic Reactions of Benzodiazafulvenium Methides, Maria I. L. Soares, Cláudio M. Nunes, Clara S. B. Gomes, Teresa M. V. D. Pinho e Melo, J. Org. Chem. 2013, 78, 628-637 [https://pubs.acs.org/doi/abs/10.1021/jo302463q ].

Functionalization of Dipyrromethanes via Hetero-Diels-Alder Reaction with Azo- and Nitrosoalkenes, Nelson A. M. Pereira, Américo Lemos, Arménio C. Serra, Teresa M. V. D. Pinho e Melo, Tetrahedron Lett. 2013, 54, 1553-1557 [http://dx.doi.org/10.1016/j.tetlet.2013.01.032].

Synthesis of chiral spirocyclopentenyl-β-lactams via phosphane-catalyzed [3+2] annulation of allenoates with 6-alkylidenepenicillanates, Bruna S. Santos, Teresa M. V. D. Pinho e Melo, Eur. J. Org. Chem. 2013, 3901-3909 [http://dx.doi.org/10.1002/ejoc.201300153].

Synthesis and Thermal Reactivity of 3-Benzyl-7-Trifluromethyl-1H,3H-Pyrrolo[1,2-c]thiazole-2,2-dioxide, Walter José Peláez, Teresa M. V. D. Pinho e Melo, Tetrahedron 2013, 69, 3646-3655 [http://dx.doi.org/10.1016/j.tet.2013.03.017].

The Neber Approach to 2-(Tetrazol-5-yl)-2H-Azirines, Ana Lúcia Cardoso, Lourdes Gimeno, Américo Lemos, Francisco Palacios, Teresa M. V. D. Pinho e Melo, J. Org. Chem. 2013, 78, 6983-6991 [https://pubs.acs.org/doi/10.1021/jo4006552#].

Reactivity of Sarcosine and 1,3-Thiazolidine-4-carboxylic Acid Towards Salicylaldehyde-derived Alkynes and Allenes, Fernanda M. Ribeiro Laia, Clara S. B. Gomes, Teresa M. V. D. Pinho e Melo, Tetrahedron 2013, 69, 10081-10090 [http://dx.doi.org/10.1016/j.tet.2013.09.052]

On-water Synthesis of Dipyrromethanes via bis-Hetero-Diels-Alder Reaction of Azo- and Nitosoalkenes with Pyrrole, Nelson A. M. Pereira, Susana M. M. Lopes, Américo Lemos, Teresa M. V. D. Pinho e Melo,Synlett 2014, 25, 423-427 [https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0033-1340300].

Recent developments in the synthesis dipyrromethanes, Nelson A. M. Pereira, Teresa M. V. D. Pinho e Melo, Organic Preparations and Procedures International: The New Journal for Organic Synthesis 2014, 46, 183-213 [ https://doi.org/10.1080/00304948.2014.903140].

1-Methyl-5-(trifluoromethyl)azafulvenium methide, an intermediate that undergoes reaction through “Unusual” cis-exo-1,3- and trans-exo-1,7-cycloadditions, Walter José Peláez, Ana Julieta Pepino, Gustavo Alejandro Argüello, Teresa M. V. D. Pinho e Melo,Eur. J. Org. Chem. 2014, 2933-2941 [https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.201301922].

Microwave-induced Pericyclic Reactions of Aza- and Diazafulvenium Methides, Maria I. L. Soares, Teresa M. V. D. Pinho e Melo, Current Microwave Chemistry 2014, 1, 22-32 [https://www.eurekaselect.com/120693/article].

Synthesis of chiral spiropyrazoline-β-lactams and spirocyclopropyl-β-lactams from 6-alkylidenepenicillanates, Bruna S. Santos, Clara S. B. Gomes, Teresa M. V. D. Pinho e Melo, Tetrahedron 2014, 70, 3812-3821 [https://www.sciencedirect.com/science/article/pii/S0040402014004712].

Targeting Triple-Negative Breast Cancer Cells with 6,7-Bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles, Kathleen Santos, Mafalda Laranjo, Margarida Abrantes, Ana F. Brito, Cristina Gonçalves, Ana Bela Sarmento Ribeiro,M. Filomena Botelho, Maria I. L. Soares, Andreia S. R. Oliveira, Teresa M. V. D. Pinho e Melo, Eur. J. Med. Chem. 2014, 79, 273-281 [https://doi.org/10.1016/j.ejmech.2014.04.008].

Selective Synthesis of Tetra-substituted 4-(Tetrazol-5-yl)-1H-Imidazoles from 2-(Tetrazol-5-yl)-2H-Azirines, Ana Lúcia Cardoso, Américo Lemos, Teresa M. V. D. Pinho e Melo, Eur. J. Org. Chem. 2014, 5159-5165 [http://dx.doi.org/10.1002/ejoc.201402559 - Cover Picture (DOI: 10.1002/ejoc.201490066)

Reactivity of Dipyrromethanes towards Azoalkenes: Synthesis of Functionalized Dipyrromethanes, Calix[4]pyrroles and Bilanes, Susana M. M. Lopes, Américo Lemos, Teresa M. V. D. Pinho e Melo, Eur. J. Org. Chem. 2014, 7039-7048 [https://doi.org/10.1002/ejoc.201402944].

Conjugate Addition of Pyrazoles to Halogenated Nitroso- ans Azo-alkenes: A New Entry to Novel Bis(pyrazol-1-yl)methanes, Carla Grosso, Américo Lemos, Teresa M.V.D. Pinho e Melo, Synlett 2014, 25, 2868-2872 [https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0034-1379306]

Reactions of Nitrosoalkenes with Dipyrromethanes and Pyrroles: Insight into the Mechanistic Pathway, Sandra C. C. Nunes, Susana M. M. Lopes, Clara S. B. Gomes, Américo Lemos, Alberto A. C. C. Pais, and Teresa M. V. D. Pinho e Melo, J. Org. Chem. 2014, 79, 10456−10465 [https://doi.org/10.1021/jo502095k]

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