Publications 2022-2023

 

  • Effectiveness of photodynamic therapy on treatment response and survival of patients with recurrent oral squamous cell carcinoma: a systematic review protocol, Miguel Cardoso, Carlos Miguel Marto, Anabela Paula, Ana Sofia Coelho, Teresa M.V.D. Pinho e Melo, Manuel Marques Ferreira, Maria Filomena Botelho, Eunice Carrilho, Mafalda Laranjo, JBI Evidence Synthesis 2022,20, 917-923 [doi:10.11124/JBIES-21-00014].
  • Cholesteryl hemiazelate causes lysosome dysfunction impacting vascular smooth muscle cells homeostasis, Liliana S. Alves, André R. A. Marques, Nuno Padrão, Filomena A. Carvalho, José Ramalho, Catarina Lopes, Maria I. L. Soares, Clare E. Futter, Teresa M. V. D. Pinho e Melo, Nuno C. Santos, Otília V. Vieira* Journal of Cell Science 2022, 135, jcs254631 [https://doi.org/10.1242/jcs.254631].
  • Portrayal of the Color Polymorphism in the 5-Acetyl-derivative of ROY, Bernardo A. Nogueira,* Maria Carvalho, José A. Paixão, M. Ermelinda S. Eusébio, Susana M. M. Lopes, Teresa M. V. D. Pinho e Melo, Rui Fausto, CrystEngComm 2022, 24, 1459-1474 [https://doi.org/10.1039/D1CE01601F].
  • Isolation and Identification of Cytotoxic Compounds Present in Biomaterial Life®, Maria Beatriz Ferreira, Nelson A. M. Pereira, Carlos Miguel Marto, Miguel Cardoso, Inês Amaro, Ana Coelho, José Sousa, Gianrico Spagnuolo, Manuel Marques Ferreira, Marta Piñeiro, Teresa M. V. D. Pinho e Melo, Maria Filomena Botelho, Eunice Carrilho, Anabela Paula* Mafalda Laranjo* Materials 2022, 15, 871 [https://doi.org/10.3390/ma15030871].
  • Ethyl 7-acetyl-8a-methyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,5,6,8a-hexahydro-7H-pyrano[2,3-c]pyridazine-1-carboxylate, Susana M. M. Lopes, Américo Lemos, José A. Paixão, Teresa M. V. D. Pinho e Melo* Molbank 2022, 2022, M1338  [https://doi.org/10.3390/M1338].
  • Ring-fused meso-Tetraarylchlorins as Auspicious PDT Sensitizers: Synthesis, Structural Characterization, Photophysics and Biological Evaluation, Mafalda Laranjo, Nelson A. M. Pereira, Andreia S. R. Oliveira, Márcia Campos Aguiar, Gonçalo Brites, Bruno F. O. Nascimento, Beatriz Serambeque, Bruna D. P. Costa, João Pina, J. Sérgio Seixas de Melo, Marta Pineiro, M. Filomena Botelho, Teresa M. V. D. Pinho e Melo* Frontiers in Chemistry (section Medicinal and Pharmaceutical Chemistry) 2022, 10, 873245 [https://www.frontiersin.org/articles/10.3389/fchem.2022.873245/full].
  • Insights into the Anticancer Activity of Chiral Alkylidene-β-Lactams and Alkylidene-γ-Lactams: Synthesis and Biological Investigation, Américo J. S. Alves, Nuno G. Alves, Mafalda Laranjo, Clara S. B. Gomes, Ana Cristina Gonçalves, Ana Bela Sarmento-Ribeiro, M. Filomena Botelho, Teresa M. V. D. Pinho e Melo* Bioorganic & Medicinal Chemistry 2022, 63, 116738 [https://doi.org/10.1016/j.bmc.2022.116738].
  • Molecular and Crystal Structures of N-Picryl-m-phenolidine and Investigation of Single Crystal Polarized Raman Spectra, Bernardo Albuquerque Nogueira,* Susana M. M. Lopes, Teresa M. V. D. Pinho e Melo, José A. Paixão, Alberto Milani, Chiara Castiglioni, Rui Fausto J. Mol. Struct. 2022,1262, 133111 [https://doi.org/10.1016/j.molstruc.2022.133111].
  • Applications of photodynamic therapy in endometrial diseases, Gabriela Barros, Beatriz Serambeque, Maria João Carvalho, Carlos Miguel Marto, Marta Pineiro, Teresa M. V. D. Pinho e Melo, Maria Filomena Botelho Mafalda Laranjo* Bioengineering 2022, 9, 226 [https://doi.org/10.3390/bioengineering9050226].
  • Color polymorphs of ROY-ol, Bernardo A. Nogueira,* Susana M. M. Lopes, Alberto Milani, Vânia André, José A. Paixão, M. Ermelinda S. Eusébio, Teresa M. V. D. Pinho e Melo, M. Teresa Duarte, Chiara Castiglioni and Rui Fausto, Crystal Growth & Design 2022, 22, 5375–5389 [https://doi.org/10.1021/acs.cgd.2c00462].
  • Unveiling a family of spiro-β-lactams with anti-HIV and anti-plasmodial activity via phosphine-catalyzed [3+2] annulation of 6-alkylidene-penicillanates and allenoates, Américo J. S. Alves, Nuno G. Alves, Inês Bártolo, Diana Fontinha, Soraia Caetano, Miguel Prudêncio, Nuno Taveira,* Teresa M. V. D. Pinho e Melo* Front.Chem. 10:1017250 (section Medicinal and Pharmaceutical Chemistry)(Published: 07 October 2022). [https://doi.org/10.3389/fchem.2022.1017250].
  • Differential Tunneling-Driven and Vibrationally-Induced Reactivity in Isomeric Benzazirines, Cláudio M. Nunes,* Srinivas Doddipatla, Gonçalo F. Loureiro, José P. L. Roque, Nelson M. A. Pereira, Teresa M. V. D. Pinho e Melo and Rui Fausto, Chem. Eur. J.2022, e202202306 [doi.org/10.1002/chem.202202306].
  • Synthesis of Novel Chiral Spiro-β-Lactams from Nitrile Oxides and 6-(Z)-(Benzoylmethylene)penicillanate: Batch, Microwave-Induced and Continuous Flow Methodologies, Américo J. S. Alves, João A. D. Silvestre and Teresa M. V. D. Pinho e Melo* RSC Advances 2022, 12, 30879 – 30891 [DOI: 10.1039/d2ra04848e].
  • High instantaneous inhibitory potential of bictegravir and the new spiro-β-lactam BSS-730A for HIV-2 isolates from RAL- naïve and RAL-failing patients, Inês Bártolo, Inês Moranguinho, Paloma Gonçalves, Ana R. Diniz, Pedro Borrego, Francisco Martin, Inês Figueiredo, Perpétua Gomes, Fátima Gonçalves, Américo J. S. Alves, Nuno G. Alves, Umbelina Caixas, Inês V. Pinto Isabel Barahona, Teresa M. V. D. Pinho e Melo, Nuno Taveira*, Int. J. Mol. Sci.2022, 23, 14300 [https://doi.org/10.3390/ijms232214300].
  • 3-(1,2,3-Triazol-4-yl)-β-Carbolines and 3-(1H-Tetrazol-5-yl)-β-Carbolines: Synthesis and Evaluation as Anticancer Agents, João L. P. Ribeiro, Joana B. Loureiro, Susana M. M. Lopes, Lucília Saraiva, Teresa M. V. D. Pinho e Melo* Pharmaceuticals 2022, 15, 1510 [Special issue “State-of-the-art of Medicinal Chemistry in Portugal”, https://doi.org/10.3390/ph15121510].
  • Ring-fused 3β-acetoxyandrost-5-enes as novel neuroprotective agents with cholinesterase inhibitory properties, Gabriel Gonzalez, Miroslav Kvasnica, Katarína Svrčková, Šárka Štěpánková, Susana M. M. Lopes,* Joana R. C. Santos, Miroslav Peřina, Radek Jorda,* Teresa M. V. D. Pinho e Melo, Journal of Steroid Biochemistry and Molecular Biology 2023, 225, 106194 [https://doi.org/10.1016/j.jsbmb.2022.106194].
  • The role of the solvent and concentration on the properties of oxime bearing A2B corroles, Ana Clara B. Rodrigues, Susana M. M. Lopes, Carla Cunha, João Braz, Teresa M. V. D. Pinho e Melo, J. Sérgio Seixas de Melo and Marta Pineiro,* Phys. Chem. Chem. Phys. 2023, 25, 10263-10277 [DOI: 10.1039/d2cp05941j].
  • Oxidized cholesteryl ester induces exocytosis of dysfunctional lysosomes in lipidotic macrophages, Neuza Domingues,* André R.A. Marques,* Rita Diogo Almeida Calado, Inês S. Ferreira, Cristiano Ramos, José Ramalho, Maria I. L. Soares, Telmo Pereira, Luís Oliveira, José R. Vicente, Louise H. Wong, Inês C. M. Simões, Teresa M. V. D. Pinho e Melo, Andrew Peden, Claúdia Guimas Almeida, Clare E. Futter, Rosa Puertollano, Winchil L.C. Vaz, and Otília V. Vieira* Traffic, 2023, 24, 284-307 [https://doi.org/10.1111/tra.12888].
  • Reactivity of Ethyl Nitrosoacrylate toward Pyrrole, Indole and Pyrrolo[3,2-c]carbazole: An Experimental and Theoretical Study, Alice Benzi, Susana M. M. Lopes, Sandra C. C. Nunes, Gianluca Giorgi, Lara Bianchi, Cinzia Tavani, Alberto A. C. C. Pais, Giovanni Petrillo, Teresa M. V. D. Pinho e Melo*, Frontiers in Chemistry (section Organic Chemistry), 11:1229669 (08 August 2023) [https://doi.org/10.3389/fchem.2023.1229669].
  • Cholesteryl hemiazelate Identified in Cardiovascular Disease Patients Causes in vitro and in vivo Inflammation, Neuza Domingues, Joana Gaifem, Rune Matthiesen, Diana Saraiva, Luís Bento, André Marques, Maria I. L. Soares, Julio Sampaio, Christian Klose, Michal A. Surma, Manuel S. Almeida, Gustavo Rodrigues, Pedro Araújo Gonçalves, Jorge Ferreira, Ryan Gouveia e Melo, Luís Mendes Pedro, Kai Simons, Teresa M. V. D. Pinho e Melo, M. Guadalupe Cabral, Antonio Jacinto, Ricardo Silvestre, Winchil Vaz, Otilia V. Vieira,* J. Lipid Res. 2023, 64(9) 100419 [https://doi.org/10.1016/j.jlr.2023.100419].
  • Novel Foscan®‑Derived Ring‑fused Chlorins for Photodynamic Therapy of Cancer, Ana I. Mata, Nelson A. M. Pereira, Ana L. Cardoso, Bruno F. O. Nascimento, Marta Pineiro, Fábio A. Schaberle, Lígia C. Gomes‑da‑Silva, Rui M. M. Brito, and Teresa M. V. D. Pinho e Melo* Bioorganic & Medicinal Chemistry 2023, 93, 117443 [https://doi.org/10.1016/j.bmc.2023.117443].
  • Organocatalysts for the Asymmetric Neber Reaction: Synthesis of Chiral 2-(Tetrazol-5-yl)-2H-Azirines, Cláudia Alves, Terver J. Sase, Cristina Gadelho, Dina Murtinho, M. Elisa S. Serra, Ana L. Cardoso, Teresa M. V. D. Pinho e Melo*, ChemistrySelect 2023, 8, e202302816 [https://doi.org/10.1002/slct.202302816].
  • Cholesteryl hemiazelate present in cardiovascular disease patients causes lysosome dysfunction in murine fibroblastos, Elizeth Lopes, Gisela Machado-Oliveira, Catarina Guerreiro Simões, Inês S. Ferreira, Cristiano Ramos, José Ramalho, Maria I. L. Soares, Teresa M. V. D. Pinho e Melo, Rosa Puertollano, André R. A. Marques,* Otília V. Vieira* Cells 2023, 12, 2826 [https://doi.org/10.3390/cells12242826].