Patents

  • PT 102623 (B) (31/10/2003). Processo para a preparação de 1,1-dióxidos de ácidos penicilânicos e de intermediários di-halogenados (Process for the Preparation of 1,1-dioxypenicillanic acids and their dihalogenated intermediates, Patente Portuguesa). Inventors: António M. d'A. Rocha Gonsalves, Teresa M. V. D. Pinho e Melo, Ana L. Cardoso, J. P. Cardoso, J. J. P. Queiroga, Dália M. Barbosa. Titular: CIPAN - Companhia Industrial Produtora de Antibióticos, S.A. -https://pt.espacenet.com/publicationDetails/biblio?FT=D&date=20031031&DB=&locale=pt_PT&CC=PT&NR=102623B&KC=B&ND=4

 

 

  • (WO2017145092) PLATINUM(II) RING-FUSED CHLORINS, METHODS AND USES THEREOF, Pub. No.: WO/2017/145092; International Application No.: PCT/IB2017/051045; Publication Date: 31.08.2017; International Filing Date: 23.02.2017; Publication Kind: A1; Inventors: Hugh Douglas Burrows, Teresa Margarida Vasconcelos Dias de Pinho e Melo, Arménio Coimbra Serra, Nelson António Melo Pereira, Liliana Marques Martelo, Marta Piñeiro Gómez,  João Sérgio Seixas de Melo, João Manuel Ferreira Pita Batista Pina, Maria Filomena Baça Roque, Botelho, Ana Margarida Coelho Abrantes, Mafalda Laranjo. Applicants: UNIV DE COIMBRA [PT];
  • EP3419977 (A1); Publication Date: 02.01.2019
  • EP 3 419 977 (B1); Publication Date: 03.01.2024, Publication Date: 03.01.2024; Inventors: Hugh Douglas Burrows, Teresa Margarida Vasconcelos Dias de Pinho e Melo, Arménio Coimbra Serra, Nelson António Melo Pereira, Liliana Marques Martelo, Marta Piñeiro Gómez,  João Sérgio Seixas de Melo, João Manuel Ferreira Pita Batista Pina, Maria Filomena Baça Roque, Botelho, Ana Margarida Coelho Abrantes, Mafalda Laranjo; Proprietor:Universidade de Coimbra, 3004-531 Coimbra (PT) [https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2017145092&redirectedID=true ]

 

  • PT 109182 A (2017/08/24) - CLORINAS FUNDIDAS DE PLATINA(II), SEUS MÉTODOS E USOS; Inventors: Hugh Douglas Burrows, Teresa Margarida Vasconcelos Dias de Pinho e Melo, Arménio Coimbra Serra, Nelson António Melo Pereira, Liliana Marques Martelo, Marta Piñeiro Gómez, João sérgio Seixas de Melo, João Manuel Ferreira Pita Batista Pina, Maria Filomena Baça Roque, Botelho, Ana Margarida Coelho Abrantes, Mafalda Laranjo. BOLETIM DA PROPRIEDADE INDUSTRIALNo 2017/08/24 (164/2017), 24 de agosto de 2017- Página 7.(http://www.marcasepatentes.pt/files/collections/pt_PT/49/55/606/628/2017-08-24.pdf)

 

  • (WO2016080853) 2-THIOXOTHIAZOLIDIN-4-ONE DERIVATIVES ACTIVE AS TRANSTHYRETIN LIGANDS AND USES THEREOF;Publication Date: 26.05.2016; Publication Kind: A1; Biocant Park Parque Tecnologico de Cantanhede Nucleo 04; Lote 2; sala 2.11 3060-197; Cantanhede (PT); Inventors: Rui Manuel Pontes Meireles Ferreira de Brito, Carlos José Vieira Simões, Teresa Margarida Vasconcelos Dias de Pinho e Melo, Bruno Lourenço da Silva Victor, Zaida Catarina Lourenço de Almeida, Ana Lúcia Cabral Lopes, Bruno Filipe Oliveira Nascimento, Maria Silvia Vieira Pereira Ferreira. Applicants: BSIM2 – BIOMOLECULAR SIMULATIONS LDA [PT];
  • US20190092737 B2, 2-THIOXOTHIAZOLIDIN-4-ONE DERIVATIVES ACTIVE AS TRANSTHYRETIN LIGANDS AND USES THEREOF. Inventors: Rui Manuel Pontes Meireles Ferreira de Brito, Carlos José Vieira Simões,Teresa Margarida Vasconcelos Dias de Pinho e Melo, Bruno Lourenço da Silva Victor, Zaida Catarina Lourenço de Almeida, Ana Lúcia Cabral Lopes, Bruno Filipe Oliveira Nascimento, Maria Silvia Vieira Pereira Ferreira (Grant Date: 2021) - Publication Kind:B2
  • US 11,584,727 B2; 2-THIOXOTHIAZOLIDIN-4-ONE DERIVATIVES ACTIVE AS TRANSTHYRETIN LIGANDS AND USES THEREOF - US20220267286 A2 (2022);  (2023) [https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2016080853]

 

  • (WO2016203402) BIS-FURAN DERIVATIVES AS TRANSTHYRETIN (TTR) STABILIZERS AND AMYLOID INHIBITORS FOR THE TREATMENT OF FAMILIAL AMYLOID POLYNEUROPATHY (FAP);Publication Date: 22.12.2016; Publication Kind: A1;Inventors: Carlos José Vieira Simões, Zaida Catarina Lourenço de Almeida, Teresa Margarida Vasconcelos Dias de Pinho e Melo, Rui Manuel Pontes Meireles Ferreira de Brito, Dora Cristina Silva Costa, Ana Lúcia Cabral Lopes. Applicants: BSIM2 – BIOMOLECULAR SIMULATIONS LDA [PT]; 
  • US 20180208570 B2 - United States Patent - BIS-FURAN DERIVATIVES AS TRANSTHYRETIN (TTR) STABILIZERS AND AMYLOID INHIBITORS FOR THE TREATMENT OF FAMILIAL AMYLOID POLYNEUROPATHY (FAP); Date of Patent: Aug. 13, 2019; Assignee: BSIM Therapeutics, S. A. Coimbra (PT)
  • EP 3.307.723.B1 - European Patent - BIS-FURAN DERIVATIVES AS TRANSTHYRETIN (TTR) STABILIZERS AND AMYLOID INHIBITORS FOR THE TREATMENT OF FAMILIAL AMYLOID POLYNEUROPATHY (FAP);  Date of Patent: Nov. 11, 2020; Assignee: BSIM Therapeutics, S. A. Coimbra (PT)
  • DK3307723 - BIS-FURANDERIVATER SOM TRANSTHYRETIN (TTR)-STABILISERINGSMIDLER OG AMYLOIDHÆMMERE TIL BEHANDLING AF FAMILIÆR AMYLOID POLYNEUROPATI (FAP); Denmark-----, Application Number: 16741140; Application Date:15.06.2016; Publication Date: 11.01.2021; Grant Number: 3307723: Grant Date: 11.01.2021; Publication Kind: T3
  • BR112017027205 (A2) - BIS-FURANDERIVATER SOM TRANSTHYRETIN (TTR)-STABILISERINGSMIDLER OG AMYLOIDHÆMMERE TIL BEHANDLING AF FAMILIÆR AMYLOID POLYNEUROPATI (FAP); Brasil; Application Number: 112017027205; Application Date:15.06.2016; Publication Date: 18.06.2019
  • [https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2016203402]

 

  • (WO/2018/207165) NOVEL SPIRO-LACTAM COMPOUNDS, PROCESS AND USES THEREOF - Pub. No.: WO/2018/207165; International Application No.: PCT/IB2018/053357; Publication Date: 15.11.2018;International Filing Date: 14.05.2018; Publication Kind: A1; Applicants: UNIVERSIDADE DE COIMBRA [PT/PT]; Paço Das Escolas 3004-531 Coimbra, PT; FACULDADE DE FARMÁCIA DA UNIVERSIDADE DE LISBOA [PT/PT]; Av. Professor Gama Pinto 1649-003 Lisboa, PT; EGAS MONIZ - COOPERATIVA DE ENSINO SUPERIOR, CRL [PT/PT]; Campus Universitário, Quinta Da Granja, Monte De Caparica 2829-511 Caparica, PT;INSTITUTO DE MEDICINA MOLECULAR [PT/PT]; Av. Prof. Egas Moniz | Ed. Egas Moniz 1649-028 Lisboa, PT; Inventors:  VASCONCELOS DIAS DE PINHO E MELO, Teresa Margarida; C. SUZANO SANTOS, Bruna; BÁRTOLO, Inês; PRUDÊNCIO PIGNATELLI, Rui Miguel; MOURA DOS SANTOS DA COSTA TAVEIRA, Nuno Eduardo.
  • EP3625238 (A1) - NOVEL SPIRO-LACTAM COMPOUNDS, PROCESS AND USES THEREOF; Publication Date: 25.03.2020;
  • US20200352916 (A1) - NOVEL SPIRO-LACTAM COMPOUNDS, PROCESS AND USES THEREOF (2020); Publication Date12.11.20
  • US 11,666,559 B2 - SPIRO-LACTAM COMPOUNDS, PROCESS AND USES THEREOF; Date of Patent: June 6, 2023
  • US2023/0285366 (A1), NOVEL SPIRO-LACTAM COMPOUNDS, PROCESS AND USES THEREOF, Publication Date: 09/14/2023
  • [https://patentscope.wipo.int/search/en/detail.jsf?docId=WO18207165&tab=PCTBIBLIO&maxRec=1000]
  • PT 110070 A (2018/11/12) - Novos Compostos Espiro-Lactâmicos, Processo e seus Usos; Inventors: Teresa Margarida Vasconcelos Dias de Pinho e Melo, Bruna C. Suzano Santos, Rui Miguel Prudêncio Pibnatelli, Inês Bártolo, Nuno Eduardo Moura dos Santos da Costa Taveira. BOLETIM DA PROPRIEDADE INDUSTRIAL, Nº 217/2018 (12/11/2018).

 

  • (WO/2019/243906) Title: (EN) (3S)- AND (3R)-6,7-BIS(HYDROXYMETHYL)-1H,3H-PYRROLO[1,2-C]THIAZOLES AS P53 ACTIVATORS; (FR) (3S)- ET (3R)-6,7-BIS (HYDROXYMÉTHYL)-1H,3H-PYRROLO[1,2-C]THIAZOLES UTILISÉS COMME ACTIVATEURS DE P53Publication Number: WO/2018/207165; Publication Date: 26.12.2019; International Application No.: PCT/IB2019/053603; International Filing Date: 02.05.2019; Publication Kind: A1Applicants: UNIVERSIDADE DO PORTO, Praça Gomes Teixeira, S/N, 4º, S.419, 4099-002 Porto, PT; UNIVERSIDADE DE COIMBRA, Paço Das Escola 3004-531 Coimbra, PT; Inventors:  ATAÍDE SARAIVA, Lucília Helena, GAMA SOARES, Joana Oliveira; VASCONCELOS DIAS DE PINHO E MELO, Teresa Margarida; LOPES SOARES, Maria Isabel; NOGUEIRA RAMOS ROCHA, Helena Isabel.
  • EP2019730929 (A1) (3S)- AND (3R)-6,7-BIS(HYDROXYMETHYL)-1H,3H-PYRROLO[1,2-C]THIAZOLES AS P53 ACTIVATORS; Publication: EP3810278A1·2021-04-28.
  • US2021315866A1 - (3S)- AND (3R)-6,7-BIS(HYDROXYMETHYL)-1H,3H-PYRROLO[1,2-C]THIAZOLES AS P53 ACTIVATORS; Publication: 2021-10-14
  • (https://worldwide.espacenet.com/patent/search/family/066867587/publication/EP3810278A1?q=pn%3DWO2019243906A1)

 

  • AMYLOID INHIBITORS AND USES THEREOF, Provisional Patent Application, United States Patent and Trademark Office (USPTO), ref. 62/083,118 (November 21th, 2014, USA). Inventors: Ana Lúcia Cabral Cardoso Lopes; Bruno Filipe Oliveira Nascimento; Bruno Lourenço da Silva Victor; Carlos José Vieira Simões; Rui Manuel Pontes Meireles Ferreira de Brito; Teresa Margarida de Vasconcelos Dias de Pinho Melo; Zaida Catarina Lourenço de Almeida. Applicant: BSIM2; Converted into Definitive Patent Application with reference PCT/PT2015/050010; European Patent Office”, 20/11/2015.

 

  • Provisional Patent Application (Portugal): NOVEL SPIRO-LACTAM COMPOUNDS, PROCESS AND USES THEREOF; Filing Date: 17.11.2023; Applicants: UNIVERSIDADE DE COIMBRA [PT/PT]; Paço Das Escolas 3004-531 Coimbra, PT; FACULDADE DE FARMÁCIA DA UNIVERSIDADE DE LISBOA [PT/PT]; Av. Professor Gama Pinto 1649-003 Lisboa, PT; EGAS MONIZ - COOPERATIVA DE ENSINO SUPERIOR, CRL [PT/PT]; Campus Universitário, Quinta Da Granja, Monte De Caparica 2829-511 Caparica, PT; Inventors:  TERESA MARGARIDA VASCONCELOS DIAS DE PINHO EMELO, NUNO EDUARDO MOURA DOS SANTOS DA COSTATAVEIRA, NUNO ALEXANDRE GUERREIRO ALVES, AMÉRICO JOSÉ DOS SANTOS ALVES, INÊS ISABEL FERNANDES BÁRTOLO.