Object of investigation: Active Pharmaceutical Ingredient solid state studies: polymorphs and cocrystals screening.
Keywords: DSC, PLTM, FTIR, XRPD, SXD, polymorphs, cocrystals, phase diagrams
PAPERS
[35]
Double-tailed long chain BODIPYs - Synthesis, characterization and preliminary studies on their use as lipid fluorescence probes
Journal of Molecular Structure xx (2017) xx
http://dx.doi.org/
[34]
Binary phase diagrams of pyridinecarboxamide isomers.
Ana M. Cortesão, João G. Henriques, Ricardo A. E. Castro, Teresa M. R. Maria, João Canotilho, M. Ermelinda S. Eusébio
Journal of Thermal Analysis and Calorimetry xx (2017) xx
http://dx.doi.org/10.1007/s10973-017-6474-2
[33]
A combined approach using differential scanning calorimetry with polarized light thermomicroscopy in the investigation of ketoprofen and nicotinamide cocrystal
G.L. Perpétuo, G.O. Chierice, L.T. Ferreira, T.F.C. Fraga-Silva, J. Venturini, M.S.P. Arruda, G. Bannach, R.A.E. Castro
Journal of Thermal Analysis and Calorimetry 651 (2017) 1-10
http://dx.doi.org/10.1016/j.tca.2017.02.014
[32]
Co-crystals of diflunisal and isomeric pyridinecarboxamides – a thermodynamics and crystal engineering contribution
Antonio O.L. Evora, Ricardo Castro, Teresa Maria, Manuela Ramos Silva, Joop H. ter Horst, João Canotilho, M. Ermelinda S. Eusébio
CrystEngComm 18 (2016) 4749-4759
Impact Factor: 4,03
http://dx.doi.org/10.1039/C6CE00380J
[31]
Studying the thermal decomposition of carvedilol by coupled TG-FTIR
R. C. Gallo, A. P. G. Ferreira, R. A. E. Castro, E. T. G. Cavalheiro
Journal of Thermal Analysis and Calorimetry 123 (2016) 2307-2312
http://dx.doi.org/10.1007/s10973-015-4931-3
[30]
Structural evidence of polymorphism and conformational isomorphism of a somewhat flexible molecule: m-anisic acid
Pedro S. Pereira Silva, Ricardo A. E. Castro, Elodie Melro, Manuela Ramos Silva, Teresa M. R. Maria, João Canotilho, M. Ermelinda S. Eusébio
Journal of Thermal Analysis and Calorimetry 120 (2015) 667-677
Impact Factor: 2.206
http://dx.doi.org/10.1007/s10973-014-4289-y
[29]
Molecular Structure and Polymorphism of a Cyclohexane Diol: trans-1,4-cyclohexanedimethanol
Mário T. S. Rosado, Teresa M. R. Maria, Ricardo A. E. Castro, João Canotilho, Manuela Ramos Silva and M. Ermelinda S. Eusébio
CrystEngComm 16 (2014) 10977-10986
Impact Factor: 3.858
http://dx.doi.org/10.1039/C4CE01211A
[28]
Synthesis and polymorphism evaluation of the 3,5-bis(decyloxy)benzaldehyde
Cláudia T. Arranja, Mariana Marcos, Manuela R. Silva, M. Ermelinda S. Eusébio, Ricardo A. E. Castro and Abílio J. F. N. Sobral
Journal of Thermal Analysis and Calorimetry 117 (2014) 1375-1383
Impact Factor: 1.982
http://dx.doi.org/10.1007/s10973-014-3904-2
[27]
A thermodynamic based approach on the investigation of a diflunisal pharmaceutical co-crystal with improved intrinsic dissolution rate
António O. L. Évora, Ricardo A. E. Castro, Teresa M. R. Maria, M. Ramos Silva, J. H. ter Horst, João Canotilho, M. Ermelinda S. Eusébio
International Journal of Pharmaceutics, 466 (2014) 68-75
Impact Factor: 3.458
http://dx.doi.org/10.1016/j.ijpharm.2014.02.048
[26]
Polymorphism of cis-1,4-cyclohexanediol, a new plastic crystal former. Considerations on isomeric cyclohexanediols plastic crystal forming abilities.
Suse V. S. Bebiano, Mário T. S. Rosado, Ricardo A. E. Castro, M. Ramos Silva, João Canotilho, Teresa M. R. Maria, M. Ermelinda S. Eusébio
Journal of Molecular Structure 1078 (2014) 10-19
Impact Factor: 1.404
http://dx.doi.org/10.1016/j.molstruc.2014.02.008
[25]
Nanostructuring of the conjugated polyelectrolyte poly[9,9-bis(4-sulfonylbutoxyphenyl)fluorene-2,7-diyl-2,2'-bithophene] in liquid crystalline C12E4 in bulk water and aligned thin films
Matti Knaapila, Sofia M Fonseca, Beverly Stewart, Mika Torkkeli, Jan Perlich, Swapna Pradhan, Ullrich Scherf, Ricardo Castro and H D Burrows
Soft Matter, 10 (2014) 3103 - 3111
Impact Factor: 3.909
http://dx.doi.org/10.1039/C4SM00092G
[24]
Thermoanalytical study of nimesulide and their recrystallization products obtained from solutions of several alcohols
D. A. Gálico, G. L. Perpétuo, R. A. E. Castro, O. Treu-Filho, A. O. Legendre, M. S. Galhiane, G. Bannach
Journal of Thermal Analysis and Calorimetry 115 (2014) 2385-2390
Impact Factor: 1.752
http://dx.doi.org/10.1007/s10973-013-3294-x
[23]
Estudo de dois polimorfos da pirazinamida por calorimetria diferencial de varrimento e espectroscopia de infravermelho
Ricardo A. E. Castro, Teresa M. R. Maria, António O. L. Évora, João Canotilho, M. Ermelinda S. Eusébio
Boletim da Sociedade Portuguesa de Química 130 (2013) 53-58
[22]
Structural characterization of solid trivalent metal dodecyl sulfates: from aqueous solution to lamellar superstructures
Rui F. P. Pereira, Artur J. M. Valente, Hugh D. Burrows, V. de Zea Bermudez, Rui A. Carvalho and Ricardo A. E. Castro
RSC Advances 3 (2013) 1420-1433
Impact Factor: 3.842
http://dx.doi.org/10.1039/c2ra21906a
[21]
Polymorphism and melt crystallisation of racemic betaxolol, a beta-adrenergic antagonist drug
Teresa M. R. Maria, Ricardo A. E. Castro, M. Ramos Silva, M. Luísa Ramos, Licínia L. G. Justino, Hugh D. Burrows, João Canotilho, M. Ermelinda S. Eusébio
Journal of Thermal Analysis and Calorimetry 111 (2013) 2171-2178
Impact Factor: 1.752
http://dx.doi.org/10.1007/s10973-012-2765-9
[20]
Thermal behavior of some antihistamines
G. L. Perpétuo, D. A. Gálico, R. A. Fugita, R. A. E. Castro, M. E. S. Eusébio, O. Treu-Filho, A. C. M. Silva and G. Bannach
Journal of Thermal Analysis and Calorimetry 111 (2013) 2019-2028
Impact Factor: 1.752
http://dx.doi.org/10.1007/s10973-012-2247-0
[19]
Resolved structures of two picolinamide polymorphs. Investigation of the dimorphic system behaviour under conditions relevant to co-crystal synthesis
António O. L. Évora, Ricardo A. E. Castro, Teresa M. R. Maria, M. Ramos Silva, João Canotilho, M. Ermelinda S. Eusébio
Crystal Engineering Communication 14 (2012) 8649-8657
Impact Factor: 3.842
http://dx.doi.org/10.1039/c2ce26244d
[18]
Naproxen co-crystals with pyridinecarboxamide isomers
Esteves de Castro, R.A.; Ribeiro, João; Maria, Teresa; Ramos Silva, Manuela; Yuste-Vivas, Consuelo; Canotilho, João; Eusébio, Ermelinda
Crystal Growth & Design 11 (2011) 5396-5404
Impact Factor: 4.389
http://dx.doi.org/10.1021/cg2009946
[17]
A new pharmaceutical co-crystal: (S)-naproxen-isonocotinamide
Consuelo Yuste-Vivas, Manuela Ramos Silva, Ricardo A. E. Castro, João D. B. Ribeiro, Teresa M. R. Maria, João Canotilho, M. Ermelinda S. Eusébio
Acta Cryst. (2011) A67, C569-C570
Impact Factor: 2.07
http://dx.doi.org/10.1107/S010876731108559X
[16]
Pyrazinamide-diflunisal: A new dual-drug co-crystal
António O.L. Évora , R.A. Esteves de Castro , Teresa Roseiro Maria , Mário Túlio dos Santos Rosado , Manuela Ramos Silva , Ana Matos Beja , João Canotilho , and Ermelinda S. Eusébio
Crystal Growth & Design 11 (2011) 4780-4788
Impact Factor: 4.389
http://dx.doi.org/10.1021/cg200288b
[15]
β-Phase Formation of Poly(9,9-dioctylfluorene) Induced by Liposome Phospholipid Bilayers
Maria José Tapia, Maria Monteserín, Hugh D. Burrows, J. Sérgio Seixas de Melo, João Pina, Ricardo A. E. Castro, Sonia Garcia, and Joan Estelrich
The Journal of Physical Chemistry B, 115 (2011) 5794-5800
Impact Factor: 3.471
http://dx.doi.org/10.1021/jp2010666
[14]
The structure of betaxolol studied by infrared spectroscopy and natural bond orbital theory
J. Canotilho, R.A.E. Castro
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 76 (2010) 395-400
Impact Factor: 1.510
http://dx.doi.org/10.1016/j.saa.2010.03.038
[13]
Polymorphism of trans-1,4-cyclohexanediol: conformational isomorphism
Teresa Maria; R.A. Esteves de Castro; Suse S. Bebiano; Manuela Ramos Silva; Ana Matos Beja; João Canotilho; Ermelinda Eusébio
Crystal Growth & Design 10 (2010) 1194-1200
Impact Factor: 4.215
http://dx.doi.org/10.1021/cg901160v
[12]
Thermal analysis and crystallization from melts: beta-adrenergic compounds
J. Canotilho, R. A. E. Castro, M. T. S. Rosado, S. C. C. Nunes and J. S. Redinha
Journal Thermal Analysis and Calorimetry 100 (2010) 423-429
Impact Factor: 1.63
http://dx.doi.org/10.1007/s10973-009-0645-8
[11]
A New Insight into Pyrazinamide Polymorphic Forms and their Thermodynamic Relationships
Ricardo A. E. Castro, Teresa M. R. Maria, António O. L. Évora, Joana C. Feiteira, M. Ramos Silva, A. Matos Beja, João Canotilho, and M. Ermelinda S. Eusébio
Crystal Growth & Design 10 (2010) 274-282
Impact Factor: 4.215
http://dx.doi.org/10.1021/cg900890n
[10]
Synthesis, spectroscopy, photophysics and thermal behavious of stilbene-based triarylamines with dehydroabietic acid methyl ester moieties
B. Gigante, M. A. Esteves, N. Pires, M.L. Davies, P. Douglas, S. M. Fonseca, H. D. Burrows, Ricardo A.E. Castro, J. Pina and J. Seixas de Melo
New Journal of Chemistry 33 (2009) 877-885
Impact Factor: 2.651
http://dx.doi.org/10.1039/b815711a
[9]
A study of the structure of the pindolol based on infrared spectroscopy and natural bond orbital theory
Ricardo A. E. Castro, João Canotilho, Sandra C. C. Nunes, M. Ermelinda S. Eusébio, J. Simões Redinha
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 72 (2009) 819–826
Impact Factor: 1.511
http://dx.doi.org/10.1016/j.saa.2008.11.026
[8]
The structure of betaxolol from single-crystal X-ray diffraction and natural bond orbital analysis
João Canotilho, Ricardo A. E. Castro, Mário T. S. Rosado, M. Ramos Silva, A. Matos Beja, J. A. Paixão, J. Simões Redinha
Journal of Molecular Structure 891 (2008) 437-442
Impact Factor: 1.486
http://dx.doi.org/10.1016/j.molstruc.2008.04.029
[7]
Interactions between hairy rod anionic conjugated polyelectrolytes and nonionic alkyloxyethylene surfactants in aqueous solution: Observations from cloud point behavior
Sofia M. Fonseca, M. Ermelinda Eusébio, Ricardo Castro, Hugh D. Burrows, Maria José Tapia, Ulf Olsson
Journal of Colloid and Interface Science 315 (2007) 805–809
Impact Factor: 2.309
http://dx.doi.org/10.1016/j.jcis.2007.07.006
[6]
Solvation enthalpy and the thermodynamics of hydration of trans-cyclohexyl-1,4-diamine and cis-cyclohexyl-1,2-diamine
Luciana I.N. Tomé, A.J. Lopes Jesus, R.A. Esteves de Castro,M. Helena S.F. Teixeira,João Canotilho, M. Ermelinda S. Eusébio
Journal of Chemical Thermodynamics 39 (2007) 1357–1362
Impact Factor: 1.939
http://dx.doi.org/10.1016/j.jct.2007.07.006
[5]
Conformational isomorphism of organic crystals. Racemic and homochiral atenolol
R. A. Esteves de Castro, João Canotilho, Rui M. Barbosa, M. Ramos Silva, A. Matos Beja, J. A. Paixão, J. Simões Redinha
Crystal Growth & Design 7 (2007) 496-500
Impact Factor: 4.215
http://dx.doi.org/10.1021/cg0601857
[4]
Infrared spectroscopy of racemic and enantiomeric forms of atenolol
R.A. Esteves de Castro, João Canotilho, Rui M. Barbosa, J. Simões Redinha
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 67 (2007) 1194-1200
Impact Factor: 1.511
http://dx.doi.org/10.1016/j.saa.2006.10.007
[3]
Novel organic hole transport layers for molecular electronic systems
H. D. Burrows, R. A. E. Castro, M. A. Esteves, B. Gigante, (the late) M. L. P. Leitão e A. C. Pauleta
Materials Science Forum 514-516 (2006) 8-12
Impact Factor: 0.399
http://dx.doi.org/10.4028/www.scientific.net/MSF.514-516.8
[2]
Infrared study of the acidic and basic forms of betaxolol
J. Canotilho, R. A. Esteves de Castro, M. H. S. F. Teixeira, M. Luísa P. Leitão, J. Simões Redinha
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 64 (2006) 279-286
Impact Factor: 1.511
http://dx.doi.org/10.1016/j.saa.2005.07.021
[1]
Phase transition of 1,2-cyclohexanediol isomers studied by polarised light microscopy and differential thermal analysis
M. Luísa P. Leitão, Ricardo A. E. Castro, Felisbela S. Costa, J. S. Redinha
Thermochimica Acta 378 (2001) 117-124
Impact Factor: 1.562
http://dx.doi.org/10.1016/S0040-6031(01)00590-1
THESIS
[1]
Antagonistas Adrenérgicos Selectivos Beta 1: Estrutura do Atenolol
Tese de Doutoramento na especialidade de Química Farmacêutica apresentada à Faculdade de Farmácia da Universidade de Coimbra em 2007
https://estudogeral.sib.uc.pt/handle/10316/552
[2]
Estudos de Termomicroscopia e Calorimetria de Solução de Derivados Hidroxilados do Ciclo-Hexano
Tese de Mestrado em Química área de Química-Física apresentada no Departamento de Química da Universidade de Coimbra em 2000