UC.PT

Ivan Viegas

Email: iviegas@uc.pt | Twitter: @IvanViegasLab

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(última atualização 17-01-2023)

Últimas notícias

- Artigo na Aquafeed sobre Palma et al. (2023) 

- Investigação em destaque na FCTUC: Video

- Sobre Toomey et al. (2022):

• Capa para a edição da Current Biology 32(19); Creditos PM Araújo;
• Escolha do Editor: Hill, GE (2022) Evolution: The biochemistry of honest sexual signaling. Current Biology 32(19) R1005 - R1007;
• Nature News and Views: Bray N (2022) On being and seeing red. Nature 609: 250.

- Vejam o nosso novíssimo logótipo para o projeto ConTribuT! 

- Sobre as nossas recentes publicações de 2022a 2022b: comunicado de imprensa / Público / MisPesces / Visão / As Beiras

- A nossa participação no 90 Segundos de Ciência para a rádio Antena 1

 

Interesses de investigação atuais

- Aquacultura e metabolismo de peixe: compreender o metabolismo dos peixes carnívoros importantes para a aquacultura do sul da Europa, como a dourada (S. aurata) e o robalo (D. labrax), e a nível mundial, como a truta arco-íris (O. mykiss), o barramundi / robalo asiático (L. calcarifer) e o tambaqui da Amazónia (C. macropomum).

- Estudos com tracers em peixes: seguimento de novos ingredientes para aquacultura e desenvolvimento de abordagens experimentais para estudar a regulação nutricional, enzimática e hormonal do metabolismo intermediário utilizando isótopos estáveis como ²H e ¹³C por Ressonância Magnética Nuclear (RNM).

- Metabolómica baseada em RNM em peixes: desenvolver ferramentas para metabolómica em tecidos de peixes e aplicações no contexto de aquacultura.

- Fisiologia comparativa e abordagens transversais ao metabolismo - dos peixes à obesidade e diabetes em mamíferos, acumulação de gordura em aves migratórias, aumento da produtividade em mosca-soldado-negro (Hermetia illucens), novos ingredientes para rações em leitões.

 

>>>> Ver secções dedicadas abaixo <<<<

 

Publicações recentes (3)

Palma M, Magnoni LJ, Morais S & Viegas I (2023) Tributyrin supplementation in fish and crustacean nutrition: A review. Reviews in Aquaculture 15:785–800.

Martins et al. (2022) Impact of dietary Chlorella vulgaris and feed enzymes on health status, immune response and liver metabolites in weaned piglets. Scientific Reports 12: 16816

Toomey et al. (2022) A mechanism for red coloration in vertebrates. Current Biology 32: 4201-4214.e4212.

 

Glicerol como ingrediente alternativo para rações de peixe - potencial para aquacultura _{(maioritariamente do projeto PEIXEROL [PTDC/CVT-NUT/2851/2014; financiado pelo Fundo Europeu de Desenvolvimento Regional (FEDER) através do COMPETE 2020 e por fundos nacionais através da Fundação para a Ciência e a Tecnologia (FCT; Portugal)]}

Viegas et al. (2022) On the Utilization of Dietary Glycerol in Carnivorous Fish - Part I: Insights Into Hepatic Carbohydrate Metabolism of Juvenile Rainbow Trout (Oncorhynchus mykiss) and European Seabass (Dicentrarchus labrax). Front Mar Sci 9: 836610.

Viegas et al. (2022) On the Utilization of Dietary Glycerol in Carnivorous Fish—Part II: Insights Into Lipid Metabolism of Rainbow Trout (Oncorhynchus mykiss) and European Seabass (Dicentrarchus labrax). Front Mar Sci 9: 836612.

Tavares et al. (2022) Towards a semi-automated analysis of fish plasma by ¹H NMR metabolomics - applications to aquaculture. Aquaculture 552: 738028.

Magnoni et al. (2021) Dietary glycerol inclusion decreases growth performance and nitrogen retention efficiency in rainbow trout (Oncorhynchus mykiss). Aquaculture: 736383.

Louvado et al. (2020) Effect of glycerol feed-supplementation on seabass metabolism and gut microbiota. Appl Microbiol Biotechnol 104: 8439-8453.

Panserat et al. (2020) Hepatic Glycerol Metabolism-Related Genes in Carnivorous Rainbow Trout (Oncorhynchus mykiss): Insights Into Molecular Characteristics, Ontogenesis, and Nutritional Regulation. Front Physiol 11:882.

Palma et al. (2019) Metabolic Effects of Dietary Glycerol Supplementation in Muscle and Liver of European Seabass and Rainbow Trout by ¹H NMR Metabolomics. Metabolites 9: 202.

Rito et al. (2019) Utilization of glycerol for endogenous glucose and glycogen synthesis in seabass (Dicentrarchus labrax): A potential mechanism for sparing amino acid catabolism in carnivorous fish. Aquaculture 498: 488-495.

 

Metabolómica de peixe baseada em RMN

Tavares et al. (2022) Towards a semi-automated analysis of fish plasma by ¹H NMR metabolomics - applications to aquaculture. Aquaculture 552: 738028.

Ferrari et al. (2022) Carbohydrate tolerance in Amazon tambaqui (Colossoma macropomum) revealed by NMR-metabolomics - Are glucose and fructose different sugars for fruit-eating fish? Comp Biochem Physiol D Genom Proteom 41: 100928.

Palma et al. (2021) Digesta and Plasma Metabolomics of Rainbow Trout Strains with Varied Tolerance of Plant-Based Diets Highlights Potential for Non-Lethal Assessments of Enteritis Development. Metabolites 11: 590.

Palma et al. (2020) Limitations to starch utilization in barramundi (Lates calcarifer) as revealed by NMR-based metabolomics. Front Physiol 11: 205.

Jarak et al. (2018) Response to dietary carbohydrates in European seabass (Dicentrarchus labrax) muscle tissue as revealed by NMR-based metabolomics. Metabolomics 14: 95. doi: https://doi.org/10.1007/s11306-018-1390-4

 

Utilização de rações ricas em hidratos de carbono pelos peixes carnívoros

Wade et al. (2020) Dietary starch promotes hepatic de novo lipogenesis in barramundi (Lates calcarifer). Brit J Nutr 124: 363-373.

Viegas et al. (2019) Impact of dietary starch on extrahepatic tissue lipid metabolism in farmed European (Dicentrarchus labrax) and Asian seabass (Lates calcarifer). Comp Biochem Physiol A Mol Integr Physiol 231: 170-176.

Silva-Marrero et al. (2019) The Administration of Chitosan-Tripolyphosphate-DNA Nanoparticles to Express Exogenous SREBP1a Enhances Conversion of Dietary Carbohydrates into Lipids in the Liver of Sparus aurata. Biomolecules 9: 297.

Viegas et al. (2016) Effects of dietary carbohydrate on hepatic de novo lipogenesis in European seabass (Dicentrarchus labrax L.). J Lipid Res 57: 1264-1272.

Viegas et al. (2015) Contribution of dietary starch to hepatic and systemic carbohydrate fluxes in European seabass (Dicentrarchus labrax L.). Brit J Nutr 113: 1345-1354.

 

Adaptações metabólicas de peixes carnívoros ao jejum e realimentação

Silva-Marrero et al. (2017) A transcriptomic approach to study the effect of long-term starvation and diet composition on the expression of mitochondrial oxidative phosphorylation genes in gilthead sea bream (Sparus aurata). BMC Genomics 18: 768.

Viegas et al. (2014) Expressional regulation of key hepatic enzymes of intermediary metabolism in European seabass (Dicentrarchus labrax) during food deprivation and refeeding. Comp Biochem Physiol A Mol Integr Physiol 174 38-44. doi:

Viegas et al. (2013) Effects of food-deprivation and refeeding on the regulation and sources of blood glucose appearance in European seabass (Dicentrarchus labrax L.). Comp Biochem Physiol A Mol Integr Physiol 166 399-405.

Viegas et al. (2012) Hepatic glycogen synthesis in farmed European seabass (Dicentrarchus labrax L.) is dominated by indirect pathway fluxes. Comp Biochem Physiol A Mol Integr Physiol 163 22-29.

Viegas et al. (2011) Analysis of glucose metabolism in farmed European sea bass (Dicentrarchus labrax L.) using deuterated water. Comp Biochem Physiol A Mol Integr Physiol 160: 341-347.

 

Desenvolvimento de ferramentas baseadas em RMN utilizando isótopos estáveis

Coelho M, Mahar R, Belew GD, Torres A, Barosa C, Cabral F, Viegas I, Gastaldelli A, Mendes VM, Manadas B, Jones JG & Merritt ME (2023) Enrichment of hepatic glycogen and plasma glucose from H₂18O informs gluconeogenic and indirect pathway fluxes in naturally feeding mice. NMR in Biomedicine 36: e4837.

Viegas I, Di Nunzio G, Belew GD, Torres AN, Silva JG, Perpétuo L, Barosa C, Tavares LC & Jones JG (2022) Integration of Liver Glycogen and Triglyceride NMR Isotopomer Analyses Provides a Comprehensive Coverage of Hepatic Glucose and Fructose Metabolism. Metabolites 12: 1142.

Belew et al. (2019) Transfer of glucose hydrogens via acetyl-CoA, malonyl-CoA, and NADPH to fatty acids during de novo lipogenesis. J Lipid Res 60: 2050-2056.

Silva et al. (2019) Determining contributions of exogenous glucose and fructose to de novo fatty acid and glycerol synthesis in liver and adipose tissue. Metabol Eng 56: 69-76.

Rito et al. (2018) Disposition of a Glucose Load into Hepatic Glycogen by Direct and Indirect Pathways in Juvenile Seabass and Seabream. Scientific Reports 8: 464.

Marques et al. (2016) Determination of muscle protein synthesis rates in fish using ²H₂O and ²H NMR analysis of alanine. Anal Biochem 509: 111-114.

Viegas et al. (2011) Analysis of glucose metabolism in farmed European sea bass (Dicentrarchus labrax L.) using deuterated water. Comp Biochem Physiol A Mol Integr Physiol 160: 341-347.

 

Adaptações metabólicas de aves migratórias de longa distância

Toomey et al. (2022) A mechanism for red coloration in vertebrates. Current Biology 32: 4201-4214.e4212.

Araújo et al. (2022) Blood Metabolites and Profiling Stored Adipose Tissue Reveal the Differential Migratory Strategies of Eurasian Reed and Sedge Warblers. Birds 3: 359-373.

Lee M, Viegas I, Norte AC, Ramos JA & Araújo PM (2023) Assessing the fatty acid profile of migratory birds with different fuelling strategies. Ibis 165: 297-304

Araújo et al. (2019) Understanding how birds rebuild fat stores during migration: insights from an experimental study. Sci Rep 9: 10065. 

Viegas et al. (2017) Metabolic plasticity for subcutaneous fat accumulation in a long-distance migratory bird traced by ²H₂O. J Exp Biol 220: 1072-1078.

 

Estudos de diabetes e obesidade em modelos mamíferos

Amorim et al. (2022) Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems. Redox Biology 55: 102400.

Flachs et al. (2017) Induction of lipogenesis in white fat during cold exposure in mice: link to lean phenotype. Int J Obes 41: 372-380.

Varghese et al. (2016) Mechanisms Underlying the Pathogenesis of Isolated Impaired Glucose Tolerance in Humans. J Clin Endocrinol Metab 101: 4816-4824. 

Varghese et al. (2016) Diabetes-Associated Variation in TCF7L2 Is Not Associated With Hepatic or Extrahepatic Insulin Resistance. Diabetes 65: 887-892. 

Soares et al. (2012) Restoration of direct pathway glycogen synthesis flux in the STZ-diabetes rat model by insulin administration. Am J Physiol - Endocrinol Metab 303: E875-E885. 

 

Capítulos de livro

Encyclopedia of the United Nations Sustainable Development Goals - Life Below Water, Leal Filho W, Azul AM, Brandli L, Lange Salvia A, Wall T (eds). Springer International Publishing:

- Palma M & Viegas I (2020) Aquaculture: Farming Our Food in Water.

- Rito J & Viegas I (2020) Fish Farming.

 

Viegas I, Carvalho RA, Pardal MA and Jones JG (2012). Advances and Applications of Tracer Measurements of Carbohydrate Metabolism in Fish. In Türker H (Ed.) New Advances and Contributions to Fish Biology, ISBN: 978-953-51-0909-9, InTech. DOI: 10.5772/54053

 

Arquivo de notícias e eventos

La Vanguardia (ES; 2016)

ASBMB Today (Página 14; EN; 2016)

Antena 2 Ciência (Entrevista - 09:14; 2016)

TecnoAlimentar (PT; 2017)

MisPesces (ES; 2019)

Fish Metabolism - applications to aquaculture (Curso - 8h; 2019)

CSIRO Aquaculture (EN; 2020)

MisPesces (ES; 2020)

MisPesces (ES; 2021)