Anthony Burke is an associate professor with habilitation at the faculty of Pharmacy since february 2022. Before this he was a faculty member in the chemistry and biochemistry department at the University of Evora. Currently he is a member of the pharmaceutical chemistry group at the faculty of pharmacy. His main interests lie in the field of drug discovery and medicinal chemistry, harnassing the power of catalysis and enabling technologies, such as continuous flow chemistry. His principal disease targets are neurodegenarative diseases and cancer. He is affliated to the Coimbra Chemistry Centre, the Coimbra Centre for Neurosciences and LAQV-Requimte-Evora.
Selected Publications
Books
Catalytic Arylation Methods – From the Academic Lab to Industrial Processes, C.S. Marques and A.J. Burke, Wiley-VCH, Jan. 2015. 528 pages, ISBN 978-3-527-33518-3 - Wiley-VCH, Weinheim.
Active Pharmaceutical Ingredients in Synthesis, Catalytic Processes in Research and Development, A.J. Burke, C.S. Marques, G.J. Hermann and Nicholas Turner, Wiley-VCH, ISBN 978-3-527-34241-9. Sep. 2018.
Book chapters
Asymmetric Epoxidations and Sulfoxidations, AJ Burke, E.P. Carreiro, Comprehensive Inorganic Chemistry II, Asymmetric Catalysis, vol. 6, pp-309-82, J. Reedijk, K. Poeppelmeier (editors). ISBN: 9780080977744.
Amino-Cinchona derivatives in Organocatalysis in Organocatalysis: Stereoselective Reactions and Applications in Organic Synthesis, AJ. Burke and G.J. Hermann, (M. Benaglia, ed.), Physical Sciences Reviews, pp85-126, Walter de Gruyter GmbH. Organocatalysis – Stereoselective Reactions and Applications in Organic Synthesis | De Gruyter, ISBNs 978-3-11-058803-3 (book), 978-3-11-058872-9 (ebook), 978-3-11-059005-0 (pdf).
Papers
N-1,2,3-Triazole-Isatin Derivatives: Target Identification in solid tumor assays, Carolina S. Marques, Natalia Busto, Renata Freitas, Alfonso Garcia-Sosa, A. J. Burke, RSC Med. Chem. MD-RES-02-2022-000044. in press. N-1,2,3-Triazole-Isatin Derivatives: Anti-proliferation effects and target identification in solid tumour cell lines - RSC Medicinal Chemistry (RSC Publishing).
Transformation of a Chiral Glycolic Acid to an Isoaurone: Stereochemical Assignment of a Benzilic Acid Rearrangment Product, Anthony J. Burke, Carla Teixeira, Sergio F. Sousa, Chemistry: An Asian Journal. in press. 10.1002/ajoc.202100692.
Evaluation of Chromanone derivatives: Promising Privileged Scaffolds for Lead Discovery within Central Nervous System (CNS) Pathologies, Amina Moutayakine, Carolina S. Marques, Óscar López, Donatella Bagetta, Elisabete P. Carreiro, Stefano Alcaro, H. Stark, José G. Fernández-Bolaños and Anthony J. Burke, Bioorganic Medicinal Chemistry, 2022, 68, 116807. Evaluation of Chromane Derivatives: Promising Privileged Scaffolds for Lead Discovery within Alzheimer’s Disease - ScienceDirect
Ugi adducts of isatin as promising antiproliferative agents with druglike properties, Pedro Brandão, Adrián Puerta, José M. Padrón, Maxim Kuznetsov, Anthony J. Burke, Marta Pineiro, Asian J. Org. Chem. 2021, 10, 1-23. Ugi Adducts of Isatin as Promising Antiproliferative Agents with Druglike Properties (wiley.com)
Ugi reaction synthesis of oxindole-lactam hybrids as selective butyrylcholinesterase inhibitors, Brandão, Pedro; López, Óscar; Leitzbach, Luisa; Stark, Holger; Fernández-Bolaños, José; Burke, Anthony; Pineiro, Marta ACS Med. Chem. Lett. 2021, 12, 1718-1725. Ugi Reaction Synthesis of Oxindole–Lactam Hybrids as Selective Butyrylcholinesterase Inhibitors | ACS Medicinal Chemistry Letters
Petasis adducts of tryptanthrin – synthesis, biological activity evaluation and druglikeness assessment, Pedro Brandão, Carolina Marques, Eugénia Pinto, Marta Pineiro, Anthony J. Burke, New J. Chem. 2021, 45, 14633-14649. Petasis adducts of tryptanthrin – synthesis, biological activity evaluation and druglikeness assessment - New Journal of Chemistry (RSC Publishing) https://doi.org/10.1039/D1NJ02079J
Recent advances in asymmetric hydrogenation catalysis utilising spiro and other rigid C-stereogenic phosphine ligands, Gesine Hermann, Anthony J. Burke, Hans-Jürgen Federsel, J. Org. Chem. 2021, 87, 1898-1924. Perspective article. Recent Advances in Asymmetric Hydrogenation Cata lysis Utilizing Spiro and Other Rigid C-Stereogenic Phosphine Ligands | The Journal of Organic Chemistry (acs.org) 10.1021/acs.joc.1c01571 1673. Views (May 2022)
Stereoselective Benzilic Acid Rearrangements: New Developments on an Old Story, A. Moutakakine, A.J. Burke, ChemComm. 57, 2585 – 2590. Stereoselective Benzilic Acid Rearrangements: New Advances on an Old Story - Chemical Communications (RSC Publishing) https://doi.org/10.1039/D0CC07905G
Patents
Novel N-(1,2,3-Triazolmethyl)Isatin and N-(1,2,3-Triazolmethyl)-3-Hydroxy-3-aryloxindoles with Cytotoxic and Anti-Tumor Activity, C.S. Marques, N. Busto, E. Gaudio, F. Bertoni, A. J. Burke,. European Patent EP3400938.
Novel Process for Preparing 3-Substituted 2-Halo Pyridines and Analogues, Hugo Viana and AJ Burke, PT109101.
Tertiary 3-Hydroxyoxindole and 3-Alkoxyoxindole derivatives as Acetylcholinesterase and Butyrylcholinesterase Inhibitors, J. Totobenazara, P. Bacalhau, A. San Juan, C. Marques, L. Fernandes, A.T. Caldeira, M.R. Martins and AJ Burke, PT108570.
Novel Picolinamide-Cinchona Organocatalysts and derivatives, P. Barrulas and AJ Burke, WO2015052656, US9844773.