1. Personal data
Name: Maria Teresa de Teixeira Cruz
Birth place and date: Coimbra, 18 de Junho de 1968
Nationality: Portugal
2. Academic degrees
2004 PhD, Thesis: Intracellular signaling pathways involved in iNOS expression in mouse skin dendritic cells
1996 Master, Thesis: Interactions between mouse peritoneal macrophages and nanoparticles: cell toxicity and oxidative stress
1992 Degree in Pharmaceutical Sciences
3. Position
2011-present CTO and shareholder of the spin-off TOXFINDER LDA
2004--present Assistant Professor at the Faculty of Pharmacy, University of Coimbra, Portugal
1994--present Researcher at the Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
4. Area of scientific activity
Pharmacology, Immunobiology and immunotherapy; Toxicology; Inflammation
5. Supervising experience
Co-supervisor of 2 pos-doc
Supervisor and co-supervisor of 15 PhD thesis Supervisor and co-supervisor of 21 Master thesis
6. Organization of advanced courses:
Co-organization of one advanced course in Neuroimmunology, Ph.D. Program in Experimental Biology and Biomedicine (BEB), CNC
Co-organization of two advanced courses in Immunology, Ph.D. Program in Experimental Biology and Biomedicine (BEB), CNC
Co-organization of the advanced course Neurodegenerative Disorders, Program in Experimental Biology and Biomedicine (BEB), CNC
7. Participation in financed research projects (2008-present)
Title of the project: “In vitro alternative approach for chemical skin sensitization hazard: an EU legislation demand” Project F.C.T. (ref. PTDC/SAU-OSM/099762/2008)
Participation: Principal Investigator
Title of the project: “Cellular and molecular mechanisms of dendritic cells activation by skin sensitizers and irritants” Project Lierac, Group Ales, Paris
Participation: Principal Investigator
Title of the project: “Anti-inflammatory mechanism and properties of medicinal plants: a multidisciplinary research for their validation and utilization as a source of phytopharmaceuticals” Project F.C.T. (ref. PTDC/SAU-FCF/105429/2008), in collaboration with CEF
Participation: Principal Investigator at CNC
Title of the project: “Implication of sirtuin proteins in the regulation of antigen presenting cells apoptosis during leishmaniasis: a therapeutic approach” Project F.C.T
(ref. PTDC/SAU-FCF/100749/2008)
Participation: Collaborator
Title of the project: “Role and mechanism of action of immunoregulatory iNKT and DC cells in Leishmania infection: new approaches for vaccination?” Project F.C.T.
(ref. PTDC/SAU-FCF/101017/2008)
Participation: Collaborator
Title of the project: “Dissecting the molecular mechanisms of wound healing in diabetes - the role of neuropeptides” Project F.C.T. (ref. PTDC/SAU-MII/098567/2008)
Participation: Collaborator
Title of the project: “Phenolic compounds of cork: cosmetic validation, alimentary evaluation and nutraceutic potential – NutraCork”. Quadro de Referência Estratégico
Nacional (QREN) – Empresas em co-promoção project ref: 21597/2011.
Participation: Collaborator
Title of the project: “Extraction and isolation of compounds with high biological potential from by-products of the cork industry – BioactiveCork”. Quadro de Referência
Estratégico Nacional (QREN) – Empresas em co-promoção project ref: 5455/2009.
Participation: Collaborator
Title of the project: “In chemico, in silico and in vitro dendritic cell modeling to predict human respiratory allergens”
Funding Agency: John Hopkins, Bloomberg, School of Public Health, Department of Environmental Health Sciences, 615 N Wolfe Street, W7032, Baltimore, 2013
Participation: Principal Investigator
Title of the project: “Generation of a novel dendritic cell-based vaccine against glioblastoma”. Funding Agency: INOVC, 2014
Participation: co-Principal Investigator
Title of the project: “ToxVitroTesting”. Quadro de Referência Estratégico Nacional (QREN) – Empresas em co-promoção project ref: 38977, 2014
Participation: co-Principal Investigator
Title of the project: “Exosomes: putative biomarkers for respiratory and cutaneous allergens hazard”. Funding Agency: PRIME-XS project, grant agreement number
262067, funded by the European Union 7th Framework Programme, 2014
Participation: Principal Investigator
Title of the project: “Development and validation of a pilot laboratory for cell therapy (UpCells)”. Quadro de Referência Estratégico Nacional (QREN) – Empresas em
co-promoção project ref: 5378/2014
Participation: Collaborator
Title of the project: Própolis: “Modulation of antigenic presentation and differential activation of T lymphocytes”. Funding Agency: FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo), Brasil, project ref: 2015/03493-3.
Participation: Collaborator
Title of the project: project CENTRO-04-3928-FEDER-000010 - Valorization of the Thermal resorts of the Centre Region - Characterization of the bioactive potential of the thermal water resources of the Region - "Study of the therapeutic properties of thermal waters - dermocosmetic" (2017-2018).
Participation: Principal Investigator
Title of the project: “InPaCTus”, Centro de Excelência, PORTUGAL2020, projeto co-promoção "The Navigator Company"-RAIZ-Univ. Coimbra-Univ. Aveiro (subprojeto “Extractos de valor acrescentado de biomassa florestal”) (2017-2020)
Participation: Collaborator
Title of the project: HealthyAging2020, project CENTRO-01-0145-FEDER-000012-2017-2020, (2017-2020)
Participation: Collaborator
Title of the project: IBERPHENOL: Red cooperativa de investigación en el ámbito de polifenoles y sus aplicaciones industriales, project EP - INTERREG V A España Portugal (POCTEP) (2017-2018).
Participation: Collaborator
Title of the project: “Skin allergens: molecules with an improbable therapeutic application for Alzheimer’s disease” POCI-01-0145-FEDER-029369, (2018-2021)
Participation: Principal Investigator
Title of the project: “The ups and downs of cellular stress: the “MAM hypothesis” for Bipolar disorder pathophysiology” CENTRO-01-0145-FEDER-028214, (20182021)
Participation: Collaborator
Title of the project: “ImmunoDCs@CancerStemCells: Imunoterapia celular direcionada para a eliminação de células estaminais cancerígenas”, project POCI-01-0247-FEDER-033532
Participation: Collaborator
Title of the project: Vesículas extracelulares de Giardia lamblia na imunomodulação de células do hospedeiro: potencial aplicação terapêutica das EVs de Giardia na inflamação intestinal. PTDC/SAU-PAR/31506/2017 (2018-2021)
Participation: Co-PI
Title of the project: “Development of a Novel Nose-to-Brain multifunctional nanoplatform for the treatment of Depression and prevention of pharmacoresistance development”, CENTRO-01-0145-FEDER-030752 (2018-2021)
Participation: Collaborator
Title of the project: "PulManCar: Microparticles design for active compounds pulmonary delivery using insulin as model". POCI-01-0145-FEDER-029560 (2018-
2021)
Participation: Collaborator
Title of the project: “Hepatitis B therapeutic vaccine: Production of glucan-based particles towards selective delivery hepatitis B antigens to immune cells to induce antiviral activity”. POCI-01-0145-FEDER-030331 (2018-2021) Participation: Collaborator.
Title of the project: Optimization of a defined approach for skin sensitizer potency integrating in silico, in chemico and in vitro cell data for classifying chemicals accordingly to five categories (extreme, strong, moderate, weak and non-sensitizer).Cosmetics Europe 2016-2020
Participation: Principal Investigator
Title of the project: "Impact of the action of natural products on human innate immune and tumor cells." CAPES-PRINT-UNESP AGREEMENT - NOTICE 02/2019. International Research Neworks with UC participation
Participation: Principal Investigator at UC
Title of the project: "TecniCOV – Desenvolvimento de testes rápidos para monitorização de anticorpos em soro e saliva“. POCI TecniCOV, número 69745
Participation: Collaborator
8. Honors
• 1993 by Portuguese Pharmaceutical Society for best academic achievement (Hospital and Officinal Pharmacy)
• 2008 by European Society of Contact Dermatitis for the best poster in basic research
• 2008 by Lierac, Grupo Ales, Paris, “Prix de Recherche Sientific Lierac” for the best project in clinical or fundamental research on skin physiopathology
• 2010 by INOV.C, for the project "Detection of potential chemical skin sensitizers”
• 2010 by Portuguese Government to Business Ideas Competition Arrisca Coimbra with the project "In vitro Test for detection of cutaneous allergic potential of chemicals: an imposition of the new European legislation".
• 2011 by Cotec to Idea to® Product Competition, with the project Sensitizer Predictor
• 2012 by RIERC, Regional Business Ideas Competition, with Toxfinder test in vitro
• 2013 by Biocant/Caixa de Crédito Agrícola, Award for innovation and entrepreneurship
• 2018 by European Society of Contact Dermatitis for the best poster in basic research
9. Patents
• Development of a dendritic cell-derived in vitro test to detect skin sensitizers (patent PCT/PT2012/000018)
• Cork hydroglycolic extract, method for preparing same, formulations comprising said extract and use thereof Patent WO 2015152746 A1 Published on 8 October 2015.
• “Skin allergens and uses thereof in prevention and/or treatment of neurodegenerative diseases”, PPP submitted in june 2020
10. Revision of scientific articles
Scientific Reports, Toxicology and Applied Pharmacology, Pharmacological reports, Drug Discovery and Therapy, European Journal of Pharmacology, Currently
Immunological Reviews, Arabian Journal of Chemistry, Revista Peruana de Medicina Experimental Y Saúde Pública, Journal of Ethnopharmacology, Revista Brasileira de Farmacognosia, Molecules, British Journal of Medicine and Medical Research, Carbohydrate Polymers, Journal of Pharmacy and Pharmacology, Food and Chemical Toxicology, Journal of Cellular Biochemistry, Critical Care Medicine, Clinical and Experimental Allergy, Archieves of Dermatological Research.
11. Reviewer of I&D projects
Arrisca Coimbra - Business Plan Competition, University of Coimbra
Fundação para a Ciência e Tecnologia (FCT), Portugal
National Centre of Science and Technology Evaluation, Cazaquistão
Netherlands Organisation for Scientific Research (NWO/ZonMw)
The Estonian Research Council
French National Research Agency
Alzheimer's Association Research Fellowship Program
Science Fund of the Republic of Serbia
12. Editorial activity
Member of the editorial board of the Scientific Reports, IF: 5,578, Q1
Member of the editorial board of Pharmaceutics, IF: 4.773, Q1
Member of the editorial board of the Evidence-Based Complementary and Alternative Medicine, IF: 2,064, Q1
Guest Associate Editor for the Research Topic in Frontiers in Physiology: The Physiology of Inflammation – The Final Common Pathway to Disease, IF: 4,031, Q1 Associate Editor for the Research Topic in Pharmaceutics: Dendritic Cell Vaccines, IF: 4.773, Q1
13. Membership
European Registered Toxicologist (ERT)
Member of the Portuguese Society of Immunology (SPI)
Member of the Portuguese Society of Pharmacology (SPF)
Member of the Portuguese Toxicology Association (Aptox)
Member of the Pharmacists' Association (OF)
14. Bibliometric Indicators
Total number of citations (Web of Science) = 6102
h factor (Web of Science) = 31
15. Publications
Link for MyCitations (Google Scholar): http://scholar.google.com/citations?user=sFivkSoAAAAJ
ORCID http://orcid.org/ 0000-0001-9846-6754
CIÊNCIA ID 6111-F90A-3CE1ResearcherID: F-5288-2013
Scopus Author ID: 7201363895
Web of Science ResearcherID AAA-7151-2019
Research Gate: https://www.researchgate.net/profile/Maria_Cruz9
Book chapter
1. Francisco V, Costa G, Neves BM, Cruz MT, Batista MT (2013). Anti-inflammatory activity of polyphenols on dendritic cells. In polyphenols in human health and disease, Ronald Ross Watson, Victor R. Preedy and Sherma Zibadi (Ed.), ISBN: 978-0-12-398456, Elsevier Inc. (first and second edition)
2. Maria Celeste Lopes and Maria Teresa Cruz (2012). Células dendríticas, em Fundamentos da Imunologia, Fernando Arosa, Elsa Cardoso, Francisco Pacheco (Ed.), p 171-191, ISBN: 978-972-757-856-6, Lidel.
3. Bruno Miguel Neves, Maria Celeste Lopes and Maria Teresa Cruz (2012). Pathogen Strategies to Evade Innate Immune Response: A Signaling Point of View, Protein Kinases, Gabriela Da Silva Xavier (Ed.), ISBN: 978-953-51-0640-1, InTech.
4. Joana Liberal, Isabel V. Ferreira, Eliza O. Cardoso, Ana Silva, Ariane R. Bartolomeu, João Martins, Karina B. Santiago, Bruno J. Conti, Bruno M. Neves, Maria T. Batista, José M. Sforcin and Maria T. Cruz (2016). Chapter 9, part 2. Anti-Inflammatory Activity of the Honeybee Plant-Derived Products Honey, Pollen and Propolis. In Cardoso SM & Silva AMS, Chemistry, biology and potential applications of honeybee plant-derived products, ISBN 978-1-68108238-7, Bentham Science Publishers.
5. Neves B.M., Martins J.D., Ferreira I., Silva A., Cruz M.T. (2017) In Vitro Dendritic Cell-Based Test for Skin Sensitizers Identification and Potency Estimation. In: Eskes C., van Vliet E., Maibach H. (eds) Alternatives for Dermal Toxicity Testing. ISBN 978-3-319-50353-0, Springer, Cham.
6. João Calmeiro, Mylene Carrascal, Célia Gomes, Amílcar Falcão, Maria Teresa Cruz and Bruno Miguel Neves. (2018) Highlighting the Role of DC-NK Cell Interplay in Immunobiology and Immunotherapy. In Svetlana P. Chapoval (ed) Dendritic Cells. ISBN: 978-1-78984-417-7, Intechopen.
Regular papers in international scientific journals
1. Marcelo D. Catarino, Iva Fernandes, Hélder Oliveira, Mylene Carrascal, Rita Ferreira, Artur M. S. Silva, Maria Teresa Cruz, Nuno Mateus, Susana M. Cardoso Antitumor activity of Fucus vesiculosus phlorotannins through activation of apoptotic signals. Int J Mol Sci. 2021 Jul; 22(14): 7604.
2. Maria Ines Rocha, Maria José Gonçalves, Carlos Cavaleiro, Maria Teresa Cruz, Cláudia Pereira, Patrícia Moreira, Lígia Salgueiro, Artur Figueirinha. Chemical characterization and bioactive potential of Artemisia campestris L. subsp. maritima (DC) Arcang. essential oil and hydrodistillation residual waterJ Ethnopharmacol. 2021 Aug 10;276:114146.
3. D Silva, MS Ferreira, JM Sousa Lobo, MT Cruz, IF Almeida. Anti-Inflammatory Activity of Calendula officinalis L. Flower Extract. Cosmetics 2021, 8, 31.
4. Mónica Zuzarte, Pedro M P Correia, Jorge M Alves-Silva, Maria J Gonçalves, Carlos Cavaleiro, Teresa Cruz, Lígia Salgueiro. Antifungal and Anti-Inflammatory Potential of Bupleurum rigidum subsp. paniculatum (Brot.) H.Wolff Essential Oil. Antibiotics (Basel). 2021 May 17;10(5):592.
5. Conte FL, Santiago KB, Conti BJ, Cardoso EO, Oliveira LPG, Feltran GDS, Zambuzzi WF, Golim MA, Cruz MT, Sforcin JM. Propolis from southeastern Brazil produced by Apis mellifera affects innate immunity by modulating cell marker expression, cytokine production and intracellular pathways in human monocytes. J Pharm Pharmacol. 2021 Mar 4;73(2):135-144.
6. João Calmeiro, Luis Mendes, Iola Duarte, Catarina Leitão, Adriana R. Tavares, 2, Daniel A. Ferreira, Célia Gomes, João Serra, Amílcar Falcão, Maria T. Cruz, Mylene Carrascal and Bruno M. Neves. In-d.epth analysis of the impact of different serum-free media on the production of clinical-grade dendritic cells for cancer immunotherapy. Front Immunol. 2021 Feb 5;11:593363.
7. Raquel Domingues, Claúdia Pereira, Maria Teresa Cruz, Ana Silva. Therapies for Alzheimer’s disease: a metabolic perspective. Mol Genet Metab. 2021 Mar;132(3):162-172.
8. Constança Oliveira, João Calmeiro, Mylène A. Carrascal, Amílcar Falcão, Célia Gomes, Bruno Miguel Neves and Maria Teresa Cruz. Exosomes as new therapeutic vectors for pancreatic cancer treatment. Eur J Pharm Biopharm. 2021 Apr;161:4-14.
9. Cláudia P Passos, Rita M. Costa, Sónia S. Ferreira, Guido R. Lopes, Maria Teresa Cruz, Manuel A. Coimbra. Role of Coffee Caffeine and Chlorogenic Acids Adsorption to Polysaccharides with Impact on Brew Immunomodulation Effects. Foods. 2021 Feb 9;10(2):378.
10. Pereira AC, Oliveira J, Silva S, Madeira N, Pereira CMF, Cruz MT. Inflammation in Bipolar Disorder (BD): Identification of new therapeutic targets. Pharmacol Res. 2021 Jan;163:105325.
11. A Silva, AS Oliveira, CV Vaz, S Correia, R Ferreira, L Breitenfeld, J Martinez-de-Oliveira, R Palmeira-de-Oliveira, C Pereira, A Palmeira-de-Oliveira, MT Cruz. Anti-inflammatory properties of Portuguese Thermal Waters. Sci Rep. 2020 Dec 18;10(1):22313.
12. Sónia Pedreiro, Sandrine da Ressurreição, Maria Lopes, Teresa Cruz, Teresa Batista, Artur Figueirinha, Fernando Ramos. Crepis vesicaria L. subsp. taraxacifolia leaves: nutritional profile, phenolic composition and biological properties. Int J Environ Res Public Health. 2020 Dec 28;18(1):151
13. Brites GS, Ferreira I, Sebastião AI, Silva A, Carrascal M, Neves BM, Cruz MT. Allergic contact dermatitis: From pathophysiology to development of new preventive strategies. Pharmacol Res. 2020 Nov 5:105282.
14. Calmeiro J, Carrascal MA, Tavares AR, Ferreira DA, Gomes C, Cruz MT, Falcão A, Neves BM. Pharmacological Combination of Nivolumab with Dendritic Cell Vaccines in Cancer Immunotherapy: an Overview. Pharmacol Res. 2020 Nov 16:105309.
and anti-inflammatory effect of skin allergens targeting the Nrf2 signaling pathway in Alzheimer’s disease cellular models. Int J Mol Sci. 2020 Oct 21;21(20):7791.
16. Catarino MD, Silva A, Cruz MT, Mateus N, Artur, Silva AMS, Cardoso SM. Phlorotannins from Fucus. vesiculosus: Modulation of inflammatory response by blocking NF-κB signaling pathway. Int J Mol Sci. 2020 Sep 20;21(18):6897.
17. Mariana Roxo, Mónica Zuzarte, Maria José Gonçalves, Jorge M. Alves-Silva, Carlos Cavaleiro, Maria Teresa Cruz, Lígia Salgueiro (2020) Antifungal and anti-inflammatory potential of the endangered aromatic plant Thymus albicans. Sci Rep. 2020 Nov 2;10(1):18859.
18. Sebastião AI, Ferreira I, Brites G, Silva A, Neves BM, Cruz MT. NLRP3 inflammasome and allergic contact dermatitis: a connection to demystify. Pharmaceutics. 2020 Sep 11;12(9):867.
19. Oliveira A, Vaz C, Silva A, Correia S, Ferreira R, Breitenfeld L, de-Oliveira JM, Palmeira-de-Oliveira R, Pereira C, Cruz MT, Palmeira-de-Oliveira A. In vitro evaluation of potential benefits of Monfortinho Natural Mineral Water in hyperkeratotic skin conditions, Int J Biometeorol. 2020 Aug 21.
20. Alves-Silva JM, Piras A, Porcedda S, Falconieri D, Maxia A, Gonçalves M, Cruz MT, Salgueiro L. Chemical characterization and bioactivity of the essential oil from Santolina insularis, a Sardinian endemism. Nat Prod Res. 2020 Jun 4;1-5.
21. Filipa A L S Silva, Gonçalo Brites, Isabel Ferreira, Ana Silva, Bruno Miguel Neves, Jorge L G F S Costa Pereira, Maria T Cruz. Evaluating skin sensitization via soft and hard multivariate modelling. Int J Toxicol. 2020 Aug 6;1091581820944395.
22. Oliveira CSD, Moreira P, Resende J, Cruz MT, Pereira CMF, Silva AMS, Santos SAO, Silvestre AJD. Characterization and cytotoxicity assessment of the lipophilic fractions of different morphological parts of Acacia dealbata. Int. J. Mol. Sci. 2020, 21, 1814.
23. Alves-Silva, Jorge M; Guerra, Inês; Gonçalves, Maria José; Cavaleiro, Carlos; Cruz, Maria Teresa; Figueirinha, Artur; Salgueiro, Lígia. Chemical composition of Crithmum maritimum L. essential oil and hydrodistillation residual water by GC-MS and HPLC-DAD-MS/MS, and their biological activities. Industrial Crops & Products 149 (2020) 112329.
24. Clarissa Perez Faria, Bruno Miguel Neves, Ágata Lourenço, Maria Teresa Cruz, João D Martins, Ana Silva, Sónia Pereira, Maria do Céu Sousa. 2020. “Giardia lamblia Decreases NF-κB p65RelA Protein Levels and Modulates LPS-Induced Pro-Inflammatory Response in Macrophages”, Scientific Reports, 2020, 10:6234.
25. João Calmeiro, Mylène Carrascal, Adriana Tavares, Daniel Ferreira, Célia Gomes, Amílcar Falcão, Maria Teresa Cruz, Bruno Neves. Dendritic Cell Vaccines for Cancer Immunotherapy: The Role of Human Conventional Type 1 Dendritic Cells. Pharmaceutics, 2020, 12, 158 (graphical abstract selected as the cover of the special issue dendritic: Dendritic Cell Vaccines).
26. Oliveira A, Vaz C, Silva A, Correia S, Ferreira R, Breitenfeld L, de-Oliveira JM, Palmeira-de-Oliveira R, Pereira C, Cruz MT, Palmeira-de-Oliveira A. Chemical Signature and Antimicrobial Activity of Central Portuguese Natural Mineral Waters Against Selected Skin Pathogens. Environ Geochem Health. 2019 Nov 27.
27. Pereira C, Santos AE, Moreira PI, Pereira AC, Sousa FJ, Cardoso SM, Cruz MT. Is Alzheimer’s disease an inflammasomopathy? Ageing Res Rev. 2019 Dec;56:100966.
28. Alves-Silva JM, Zuzarte M, Gonçalves MJ, Cruz MT, Cavaleiro C, Salgueiro L. Unveiling the bioactive potential of the essential oil of a Portuguese endemism, Santolina impressa. J Ethnopharmacol. 2019 Nov 15;244:112120.
29. Calmeiro J, Carrascal M, Gomes C, Falcão A, Cruz MT and Neves BM. Biomaterial-based platforms for in situ dendritic cell programming and their use in antitumor immunotherapy. J Immunother Cancer. 2019 Sep 4;7(1):238.
30. Miranda M, Cruz MT, Vitorino C, Cabral C. Nanostructuring lipid carriers using Ridolfia segetum (L.) Moris essential oil. Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109804.
31. Alves M, Gonçalves MJ, Zuzarte M, Alves-Silva J, Cavaleiro C, Cruz MT, Salgueiro L. Unveiling the antifungal potential of two Iberian thyme essential oils: effect on C. albicans germ tube and preformed biofilms. Front Pharmacol. 2019 May 2;10:446
32. Fernandes O, Ferreira S, Bastos R, Ferreira I, Cruz MT, Pinto A, Coelho E, Coimbra MA, Cardoso S, Wessel D. Apple Pomace Extract as a Sustainable Food Ingredient. Antioxidants (Basel). 2019 Jun 21;8(6).
33. Matos P, Figueirinha A, Ferreira I, Cruz MT, Batista MT. Acanthus mollis L. leaves as source of anti-inflammatory and antioxidant phytoconstituents. Nat Prod Res. 2019 Jun;33(12):1824-1827.
34. Maciel E, Neves BM, Martins J, Colombo S, Cruz MT, Domingues P, Domingues MRM. Oxidized phosphatidylserine mitigates LPS-triggered macrophage inflammatory status through modulation of JNK and NF-kB signaling cascades. Cell Signal. 2019 May 2. pii: S0898-6568(19)30099-3.
35. Mendes AF, Cruz MT, Guallilo O. The Physiology of Inflammation—The Final Common Pathway to Disease. Front. Physiol., 04 December 2018
36. Jesus S, Soares E, Teresa Cruz M, Borges O. Exosomes as adjuvants for the recombinant hepatitis B antigen: first report. Eur J Pharm Biopharm. 2018 Oct 1. pii: S0939-6411(18)30402-8.
37. Paiva RA, Martins-Marques T, Jesus K, Ribeiro-Rodrigues TM, Zuzarte M, Silva A, Reis L, da Silva JM, Pereira P, Vader P, Sluijter JPG, Gonçalves L, Cruz MT, Girao H. Ischemia alters the effects of cardiomyocyte-derived extracellular vesicles on macrophage activation. J Cell Mol Med. 2019 Feb;23(2):1137-1151.
38. Liberal J, Costa G, Carmo A, Vitorino R, Marques C, Domingues MR, Domingues P, Gonçalves AC, Alves R, Sarmento-Ribeiro A, Girão H, Cruz MT,
Batista MT. Chemical characterization and cytotoxic potential of an ellagitannin-enriched fraction from Fragaria vesca leaves. Arabian Journal of Chemistry 12 (8), 2019: 3652-3666.
39. Rodrigues V, Cabral C, Évora L, Ferreira I, Cavaleiro C, Cruz MT, Salgueiro L. Chemical composition, anti-inflammatory activity and cytotoxicity of Thymus zygis subsp. sylvestris essential oil and its main compounds. Arabian Journal of Chemistry. 12 (8), December 2019: 3236-3243.
40. Zuzarte M, Alves-Silva JM, Alves M, Cavaleiro C, Salgueiro L, Cruz MT. New insights on the anti-inflammatory potential and safety profile of Thymus carnosus and Thymus camphoratus essential oils and their main compounds. J Ethnopharmacol. 2018 Oct 28;225:10-17.
41. Matos P, Figueirinha A, Paranhos A, Nunes F, Cruz P, Geraldes CFGC, Cruz MT, Batista MT. Bioactivity of Acanthus mollis - Contribution of benzoxazinoids and phenylpropanoids. J Ethnopharmacol. 2018 Sep 7;227:198-205.
42. Ferreira I, Silva A, Martins JD, Neves, BM and Cruz MT. Nature and kinetics of redox imbalance triggered by respiratory and skin chemical sensitizers on the human monocytic cell line THP-1. Redox Biol. 2018 Jun;16:75-86.
43. Melo T, Marques SS, Ferreira I, Cruz MT, Domingues P, Segundo MA, & Domingues MRM. New Insights in Anti-inflammatory and Antioxidant Properties of Nitrated Phospholipids. Lipids. 2018 Jan;53(1):117-131.
44. Gaspar MC, Fonseca DA, Antunes MJ, Frigerio C, Gomes NGM, Vieira M, Santos AE, Cruz MT, Cotrim MD, Campos MG. Polyphenolic characterisation and bioactivity of an Oxalis pes-caprae L. leaf extract. Nat Prod Res. 2018 Mar;32(6):732-738.
45. Santos SAO, Trindade SS, Oliveira CSD, Parreira P, Rosa D, Duarte MF, Ferreira I, Cruz MT, Rego AM, Abreu MH, Rocha SM, Silvestre AJD. Lipophilic Fraction of Cultivated Bifurcaria bifurcata R. Ross: Detailed Composition and In Vitro Prospection of Current Challenging Bioactive Properties. Mar Drugs. 2017 Nov 1;15(11). pii: E340.
46. Liberal J, Carmo A, Gomes C, Cruz MT, Batista MT. Urolithins impair cell proliferation, arrest the cell cycle and induce apoptosis in UMUC3 bladder cancer cells. Invest New Drugs. 2017 Dec;35(6):671-681.
47. Catarino MD, Silva AMS, Cruz MT, Cardoso SM. Antioxidant and anti-inflammatory activities of Geranium robertianum L. decoctions.Food Funct. 2017 Sep 20;8(9):3355-3365 .
48. Carvalho AR, Costa G, Figueirinha A, Liberal J, Prior JAV, Lopes MC, Cruz MT, Batista MT. Urtica spp.: Phenolic composition, safety, antioxidant and anti-inflammatory activities. Food Res Int. 2017 Sep;99(Pt 1):485-494.
49. Constantino J, Gomes CM, Falcão A, Neves BM, Cruz MT. Dendritic Cell-Based Immunotherapy: A Basic Review and Recent Advances, Immunol Res. 2017 Aug;65(4):798-810.
50. Esselin H, Sutour S, Liberal J, Cruz MT, Salgueiro L, Siegler B, Freuze I, Castola V, Paoli M, Bighelli A, Tomi F. A new tetrahydropyran C15 acetogenin from Laurencia obtuse. Molecules. 2017 May 11;22(5). pii: E779.
51. Santos T, Costa G, Pinto Ferreira J, Liberal J, Francisco V, Paranhos A, Cruz MT, Castelo-Branco M, Vitória Figueiredo I and Batista MT. Antioxidant, anti-inflammatory, and analgesic activities of Agrimonia eupatoria L. infusion: polyphenols contribution, Evidence-Based Complementary and Alternative Medicine, 2017;2017:8309894.
52. Cabral C, Miranda M, Gonçalves MJ, Cavaleiro C, Cruz MT, Salgueiro L. Assessment of safe bioactive doses of Foeniculum vulgare Mill. essential oil from Portugal.. Nat Prod Res. 2017 Nov;31(22):2654-2659.
53. da Costa E, Melo T, Moreira AS, Bernardo C, Helguero L, Ferreira I, Cruz MT, Rego AM, Domingues P, Calado R, Abreu MH, Domingues MR. Valorization of Lipids from Gracilaria sp. through Lipidomics and Decoding of Antiproliferative and Anti-Inflammatory Activity. Mar Drugs. 2017 Mar 2;15(3). pii: E62.
54. Ferreira I, Liberal J, João Martins JD, Silva A, Neves BM, Cruz MT. Inflammasome in dendritic cells immunobiology: implications to diseases and therapeutic strategies. Curr Drug Targets. 2017;18(9):1003-1018. Invitation for a Special Issue for CURRENT DRUG TARGETS (Guest Editor: Mario D. Cordero) entitled INFLAMMASOME COMPLEX IN HEALTH AND DISEASE: NEW PHARMACOLOGICAL PERSPECTIVES.
55. Guedes S, Neves BM, Vitorino R, Domingues MR, Cruz MT and Domingues P. Contact dermatitis - in pursuit of sensitizer's molecular targets through proteomics. Arch Toxicol. 2017 Feb;91(2):811-825.
56. Martins VMR, Simões J, Ferreira I, Cruz MT, Domingues MR, Coimbra MA. In vitro macrophage nitric oxide production by Pterospartumtridentatum (L.) Willk. inflorescence polysaccharides. Carbohydr Polym. 2017 Feb 10;157:176-184.
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