Academic degrees (reverse chronological order)
5/2022: Habilitation Degree in Pharmacology
12/2003: PhD in Pharmacy, specialization in Pharmacology
10/1993: Degree in Pharmaceutical Sciences, specialization in Community and Hospital Pharmacy
3/1989: Degree in Pharmaceutical Sciences, specialization in Clinical Chemistry
Professional Activities (reverse chronological order)
· 8/3/2022-present: Associate Professor, Faculty of Pharmacy, and Principal Investigator at the Centre for Neuroscience and Cell Biology (CNBC), University of Coimbra, Coimbra, Portugal
· 18/12/2003-7/3/2022: Assistant Professor, Faculty of Pharmacy, and Principal Investigator at the Centre for Neuroscience and Cell Biology (CNBC), University of Coimbra, Coimbra, Portugal
· 6/1/1996-17/12/2003: Teaching and Research Assistant, Faculty of Pharmacy, University of Coimbra
· 5/6/1993-6/1/1996: Trainee Teaching and Research Assistant, Faculty of Pharmacy, University of Coimbra
· 1/11/89-4/6/1993: Técnica Superior de Saúde-Análises Clínicas, Portuguese Oncology Institute – Coimbra Centre
· Specialist in Clinical Chemistry by the College of Pharmacists, since July 1992
Areas of scientific activity
Cellular and molecular pharmacology
Specialization domain
Physiopharmacology of aging and chronic inflammation; arthritic diseases
Books
Mobasheri A, Mendes AF (eds.) Physiology and Pathophysiology of Musculoskeletal Aging. Frontiers Research Topic E-book. Frontiers Media SA. 2015. ISBN: 978-2-88919-390-5.
Mobasheri A, Bondy CA, Moley K, Mendes AF, Rosa SC, Richardson S, Hoyland JA, Barrett-Jolley R, Shakibaei M. Articular Chondrocytes: Expression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics, Growth Factors and Pro-Inflammatory Cytokines. Adv. Anat. Embryol. Cell Biol. 2008; 200:1-84. [Berlin: Springer-Verlag. Series Editors: Beck FF, Clascá F, Frotscher M, Haines DE, Hirokawa N, Kmiec Z, Korf H-W, Marani E, Putz R, Sano Y, Schiebler TH, Timmermans J-P]. ISBN: 978-3-540-78898-0.
Articles published in international peer-reviewed journals (reverse chronological order)
Sousa C, Neves BM, Leitão AJ, Mendes AF. Elucidation of the Mechanism Underlying the Anti-Inflammatory Properties of (S)-(+)-Carvone Identifies a Novel Class of Sirtuin-1 Activators in a Murine Macrophage Cell Line. Biomedicines. 2021; 9(7): 777. DOI: 10.3390/biomedicines9070777.
Gomes P, Leal H, Mendes AF, Reis F, Cavadas C. Dichotomous Sirtuins: implications for drug discovery in neurodegenerative and cardiometabolic diseases. Trends Pharmacol Sci. 2019; 40: 1021-1039. DOI: 10.1016/j.tips.2019.09.003.
Gaspar LS, Álvaro AR, Carmo-Silva S, Mendes AF, Relógio A, Cavadas C. The importance of determining circadian parameters in pharmacological studies. Br J Pharmacol. 2019; 176: 2827-2847. DOI: 10.1111/bph.14712.
Luchetti F, Falcieri E, Mendes AF. The “Journal of Functional Morphology and Kinesiology” Journal Club Series: Highlights on Recent Papers in Exercise-Induced Immune Response. J Functional Morphol Kinesiol. 2018; 3: 42. DOI: 10.3390/jfmk3030042.
Rufino A, Ribeiro M, Pinto Ferreira J, Judas F, Mendes AF. Hyperglycemia and Hyperinsulinemia-Like Conditions Independently Induce Inflammatory Responses in Human Chondrocytes. J Funct Morphol Kinesiol. 2017; 2: 15. DOI: 10.3390/jfmk2020015.
Sousa C, Ribeiro M, Rufino AT, Leitão AJ, Mendes AF. Assessment of cell line competence for studies of pharmacological GPR30 modulation. J Receptors Signal Transduction. 2017; 37(2): 181-188. DOI: 10.1080/10799893.2016.1203943.
Ribeiro, M., P. López de Figueroa, U. Nogueira-Recalde, A. Centeno, A.F. Mendes, F.J. Blanco, and B. Caramés. Diabetes-accelerated Experimental Osteoarthritis is Prevented by Autophagy Activation. Osteoarthritis Cartilage. 2016; 24(12): 2116-2125. DOI: 10.1016/j.joca.2016.06.019
Szychlinska MA, Vadalà G, Workman V, Ripamonti U, Mendes AF, Stoddart MJ, Alini M. The "Journal of Functional Morphology and Kinesiology" Journal Club Series: Highlights on Recent Papers in Articular Cartilage Tissue Engineering and Mechanical Stimulation. J Functional Morphol Kinesiol. 2016; 1:162-166 Doi:10.1080/10799893.2016.1203943
Ribeiro, M., López de Figueroa, P., Blanco, F., Mendes, A.F., Caramés, B. Insulin decreases autophagy and leads to cartilage degradation. Osteoarthritis Cartilage. 2016;24: 731-739 Doi: 10.1016/j.joca.2015.10.017
Rufino, A. T., Ribeiro, M., Sousa, C., Judas, F., Salgueiro, L., Cavaleiro, C., Mendes, A. F. (2015). Evaluation of the anti-inflammatory, anti-catabolic and pro-anabolic effects of E-caryophyllene, myrcene and limonene in a cell model of osteoarthritis. Eur J Pharmacol. 2015; 750, 141-150. doi:10.1016/j.ejphar.2015.01.018.
Rufino, A., Ferreira, I., Judas, F., Salgueiro, L., Lopes, M., Cavaleiro, C., Mendes, A. Differential effects of the essential oils of Lavandula luisieri and Eryngium duriaeisubsp. juresianum in cell models of two chronic inflammatory diseases. Pharmaceutical Biol. 2015; 53 (8): 1220-1230. doi:10.3109/13880209.2014.970701.
Serra D, Rufino AT, Mendes AF, Almeida LM, Dinis TC.. Resveratrol modulates cytokine-induced Jak/STAT activation more efficiently than 5-aminosalicylic acid: an in vitro approach. PLoS One 2014; 9(10):e109048.
Rufino AT, Ribeiro M, Judas F, Salgueiro L, Lopes MC, Cavaleiro C, Mendes AF. Anti-inflammatory and Chondroprotective Activity of (+)-α-Pinene: Structural and Enantiomeric Selectivity. J Nat Prod. 2014; 77(2): 264–269 Doi: 10.1021/np400828x.
Rufino AT, Rosa SC, Judas F, Mobasheri A, Lopes MC, Mendes AF. Expression and function of K(ATP) channels in normal and osteoarthritic human chondrocytes: possible role in glucose sensing. J Cell. Biochem. 2013; 114:1879–1889.
Mobasheri A, Mendes AF (2013). Physiology and pathophysiology of musculoskeletal aging: current research trends and future priorities. Front Physiol. 2013; 4:73. doi: 10.3389/fphys.2013.00073
Mobasheri A, Lewis R, Ferreira-Mendes A, Rufino A, Dart C, Barrett-Jolley R.Potassium channels in articular chondrocytes. Channels. 2012; 6:1-10.
S. C. Rosa, A. T. Rufino, F. Judas, C. Tenreiro, M. C. Lopes, A. F. Mendes. Role of glucose as a modulator of anabolic and catabolic gene expression in normal and osteoarthritic human chondrocytes. J. Cell. Biochem. 2011; 112: 2813-2824.
S. C. Rosa, A. T. Rufino, F. Judas, C. Tenreiro, M. C. Lopes, A. F. Mendes.Expression and function of the insulin receptor in normal and osteoarthritic human chondrocytes: modulation of anabolic gene expression, glucose transport and GLUT-1 content by insulin. Osteoarthritis Cartilage 2011; 19:719-727.
Judas F, Saavedra MJ, Mendes AF, Dias R. Cortical strut allografting in reconstructive surgery in orthopaedic surgery. Acta Reumatologica Portuguesa 2011; 36: 24-28.
Neves, S.C. Rosa, J. Gonçalves, A. Rufino, F. Judas, M.C. Lopes, L. Salgueiro, C. Cavaleiro, A.F. Mendes. Screening of five essential oils for identification of potential inhibitors of IL-1-induced NF-kB activation and NO production in human chondrocytes: characterization of the inhibitory activity of a-pinene. Planta Med. 2010; 76(3):303-308.
S.C. Rosa, J. Gonçalves, F. Judas, M.C. Lopes, A.F. Mendes. Assessment of strategies to increase chondrocyte viability in cryopreserved human osteochondral allografts: evaluation of the glycosylated hydroquinone, arbutin. Osteoarthritis Cartilage. 2009; 17:1657-61.
Rosa S.C., Gonçalves J, Judas F., Mobasheri A, Lopes M.C., Mendes A.F. Impaired GLUT-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage. Arthritis Res Ther. 2009; 11: R80.
Rosmaninho-Salgado J, Araujo I, Alvaro AR, Mendes AF, Ferreira L, Grouzmann E, Mota A, Duarte EP, Cavadas C. Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1 beta: role of neuropeptide Y and nitric oxide. J Neurochem. 2009; 109: 911-922. Doi 10.1111/j.1471-4159.2009.06023.x
S.C. Rosa, F. Judas, M.C. Lopes, A.F. Mendes. Nitric oxide synthase isoforms and NF-κB activity in normal and osteoarthritic human chondrocytes: Regulation by inducible nitric oxide. Nitric Oxide. 2008; 19: 276-283.
Judas F, Rosa S, Teixeira L, Lopes C, Mendes AF. Chondrocyte viability in fresh and frozen large human osteochondral allografts: effect of cryoprotective agents. Transplant. Proc. 2007; 39: 2531-2534.
Mendes A.F., Caramona M.M., Carvalho A.P., Lopes M.C. Differential roles of hydrogen peroxide and superoxide in mediating IL-1-induced NF-kB activation and iNOS expression in bovine articular chondrocytes. J. Cell. Biochem. 2003; 88: 783‑793.
Mendes A.F., Caramona M.M., Carvalho A.P., Lopes M.C. Hydrogen peroxide mediates Interleukin-1b-induced AP-1 activation in articular chondrocytes: implications on the regulation of iNOS Expression. Cell Biol. Toxicol. 2003; 19: 203-214.
Castro-Caldas M., Mendes A.F., Carvalho A.P., Duarte C.B., Lopes M.C. Dexamethasone prevents interleukin-1b-induced nuclear factor-kB activation by upregulating IkB-a synthesis, in lymphoblastic cells. Med. Inflamm. 2003; 12: 37-46.
Castro-Caldas M., Mendes A.F., Duarte C.B., Lopes M.C. Dexamethasone- and estradiol-induced CREB activation and annexin 1 expression in CCRF-CEM lymphoblastic cells: evidence for the involvement of cAMP and p38 MAPK. Med. Inflamm. 2003, 12: 329-337.
Mendes A.F., Carvalho A.P, Caramona M.M., Lopes M.C. Role of Nitric oxide on the activation of NF-kB, AP-1 and NOS II expression in articular chondrocytes. Inflamm. Res. 2002; 51: 369-375.
Mendes A.F., Caramona M.M., Carvalho A.P, Lopes M.C. Diacerhein and Rhein prevent interleukin-1b-induced nuclear factor-kB activation by inhibiting the degradation of inhibitor kB-a. Pharmacol. Toxicol. 2002; 91: 22-28.
Mendes A.F., Caramona M.M., Carvalho A.P, Lopes M.C. Role of mitogen‑activated protein kinases and tyrosine kinases on IL-1-induced NF-kB activation and iNOS expression in bovine articular chondrocytes. Nitric Oxide. 2002; 6: 35‑44.
Mendes A.F., Carvalho A.P, Caramona M.M., Lopes M.C. Diphenyleneiodonium inhibits NF-kB activation and iNOS expression induced by IL-1b: involvement of reactive oxygen species. Med. Inflamm. 2001; 10: 209-215.
Mendes A.F., Caramona M.M., Lopes M.C. Changes in the subcellular distribution of the rat uterus oestrogen receptor as induced by oestradiol, tamoxifen and ZD 182,780. J. Pharm. Pharmacol. 1996; 48: 302-305.
Commentaries to research articles
Mobasheri A and Ferreira Mendes A: F1000Prime Recommendation of [Weimer S et al., Nat Commun 2014, 5: 3563]. In F1000Prime, 08 Aug 2014; DOI: 10.3410/f.718342636.793498083.
Mobasheri A and Ferreira Mendes A: F1000Prime Recommendation of [Furman BD et al., Arthritis Res Ther 2014, 16(3): R134]. In F1000Prime, 03 Jul 2014; DOI: 10.3410/f.718469060.793496676.
Mobasheri A and Ferreira Mendes A: F1000Prime Recommendation of [Kwoh CK et al., Arthritis Rheumatol 2014, 66(4): 930-9]. In F1000Prime, 13 May 2014; DOI: 10.3410/f.718336623.793494812.
Mobasheri A and Ferreira Mendes A: F1000Prime Recommendation of [Bomer N et al., Ann Rheum Dis 2014]. In F1000Prime, 22 Apr 2014; DOI: 10.3410/f.718337036.793493784.
Abstracts published in international peer-reviewed journals (2010-2016 in reverse chronological order)
Ribeiro, M., Lopez de Figueroa, P., Nogueira, U., Mendes, A. F., Blanco, F. J., Carames, B. Diabetes-accelerated experimental osteoarthritis is prevented by mTOR inhibition. Osteoarthritis and Cartilage 24, S59-S60 (2016).
A. F. Mendes, S. C. Rosa, A. T. Rufino, M. Ribeiro, F. Judas. Diabetes-induced osteoarthritis: role of hyperglycemia in joint destruction. BMC Musculoskeletal Disorders 2015; 16(Suppl 1):S1
B. Carames, M. Ribeiro, P. Lopez de Figueroa, A.F. Mendes, F.J. Blanco. Insulin-induced cartilage degradation in osteoarthritis is associated to defective autophagy. Ann Rheum Dis. 2015; 74:662 DOI: 10.1136/annrheumdis-2015-eular.4587
Ribeiro M, Lopez de Figueroa P, Blanco FJ, Mendes AF, Carames B. Diabetes-accelerated cartilage degradation in osteoarthritis is associated with defective autophagy. Osteoarthritis Cartilage 2015; 23 (Suppl. 2): A154
Rufino AT, Ribeiro M, Judas F, Lopes MC, Mendes AF. Hyperglycemia-like culture conditions induce IL-1β and TNF-α expression and impair autophagy in human chondrocytes. Osteoarthritis Cartilage 2014; 22 (Suppl.): S165-S166 (P274).
Rufino AT; Ribeiro M, Judas F, Lopes MC, Mendes AF. Culture of human chondrocytes in high glucose induces inflammatory markers and impairs autophagy. Ann Rheum Dis 2014;73:A63 doi:10.1136/annrheumdis-2013-205124.143
Rufino AT, Cavaleiro C, Judas F, Salgueiro L, Lopes MC, Mendes AF. The essential oil of Eryngium duriaei subsp. juresianum inhibits IL-1β induced NF-kB and MAPK activation in human chondrocytes. Osteoarthritis Cartilage. 2012; 20 (Suppl. 1): S290 (P580).
A.T. Rufino, F. Judas, L. Salgueiro, M.C. Lopes, C. Cavaleiro, A.F. Mendes. Screening of essential oils as potential sources of natural inhibitors of iNOS expression and NO production in human chondrocytes. Osteoarthritis Cartilage. 2011; 19 (suppl. 1): S231 (P501).
Mendes AF, Rosa SC, Judas F, Lopes MC. NF-B activity is reduced by iNOS-derived NO in human chondrocytes: contribution to sustained low grade inflammation in osteoarthritis. Inflamm. Res. 2011; 60 (suppl.1): S78 (OC123).
Mendes AF, Rosa SC, Rufino A, Judas F, Salgueiro L, Lopes MC, Cavaleiro C. Dual inhibition of IL-1-induced NF-B activation and iNOS activity in human chondrocytes by alpha-pinene. Inflamm. Res. 2011; 60 (suppl.1): S235 (P459).
Rosa S, Gonçalves J, Judas F, Salgueiro L, Cavaleiro C, Lopes C, Mendes AF. Alpha-pinene inhibits interleukin-1-induced nitric oxide production by NF-kB-dependent and independent mechanisms in human chondrocytes. Basic Clin Pharmacol Toxicol. 2010;107 (Suppl 1): P548.
M.C. Lopes, S.C. Rosa, F. Judas, A. F. Mendes. Inducible nitric oxide downregulates NF-kB activity in human chondrocytes: implications in osteoarthritis. Int Immunol. 2010; 22 (Supp I): i48 (PP-005-08).
Rosa SC, Rufino A, Judas F, Lopes C, Mendes AF. Role of high extracellular glucose concentrations in modulating anabolic and catabolic gene expression in normal and osteoarthritic human chondrocytes. Osteoarthritis Cartilage. 2010; 18 (Suppl. 2): S93 (P195).
Rufino A, Rosa S, Judas F, Mobasheri A, Lopes MC, Mendes AF. Role of K(ATP) channels in modulating GLUT-1 content in normal and OA human chondrocytes. Osteoarthritis Cartilage. 2010; 18 (Suppl. 2): S101 (P214).
Oral communications (2010-2016 in reverse chronological order)
Carames M*, Ribeiro M, Lopez de Figueroa P, Nogueira-Recalde U, Centeno A, Mendes AF, Blanco FJ. Diabetes-accelerated experimental osteoarthritis is prevented by autophagy activation. Annual European Congress of Rheumatology, Londres, Junho de 2016.
Ribeiro M*, Lopez de Figueroa P, Nogueira U, Mendes AF, Blanco FJ, Carames B. Diabetes‑accelerated experimental osteoarthritis is prevented by mTOR inhibition. 2016 World Congress on Osteoarthritis, Amsterdão, 31 Março- 3 Abril de 2016.
Ribeiro M*, Lopez de Figueroa P, Nogueira U, Mendes AF, Blanco FJ, Carames B. Diabetes‑accelerated experimental osteoarthritis is prevented by mTOR inhibition. XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia. Porto, Fevereiro de 2016.
Sousa C*, Ribeiro M, Rufino AT, Leitão AJ, Mendes AF. Validation of a screening assay for GPR30 ligands: an unexpected result. XLV Reunião Anual da Sociedade Portuguesa de Farmacologia. Lisboa, Fevereiro de 2015.
Ribeiro M*, Lopez de Figueroa P, Blanco FJ, Mendes AF, Carames B. Diabetes-accelerated cartilage degradation in osteoarthritis is associated to defective autophagy. XLV Reunião Anual da Sociedade Portuguesa de Farmacologia. Lisboa, Fevereiro de 2015.
Rufino AT*, Judas F, Salgueiro L, Cavaleiro C, Mendes AF. Hyperglycemia induces inflammatory mediators in human chondrocytes: inhibition by the essential oil of Lavandula luisieri. XLIV Reunião Anual da Sociedade Portuguesa de Farmacologia. Coimbra, Fevereiro de 2014.
Rufino AT*, Cavaleiro C, Judas F, Salgueiro L, Lopes MC, Mendes AF. Inhibition of inflammatory and catabolic responses in human chondrocytes by (+)-α-pinene. XLIII Reunião Anual da Sociedade Portuguesa de Farmacologia. Porto, Fevereiro de 2013.
Ferreira I*, AT Rufino, MC Lopes, L Salgueiro, C Cavaleiro, AF Mendes. Pharmacological screening of essential oils for identification of NF-κB and iNOS inhibitors in a human intestinal epithelial cell line. 6th European Congress of Pharmacology (EPHAR 2012). Granada, Julho de 2012.
Rufino AT*, Cavaleiro C, Judas F, Salgueiro L, Lopes C, Mendes AF. Inhibition of IL-1β induced pro-inflammatory and catabolic signaling pathways in human chondrocytes by the essential oil of Eryngium duriaei subsp. Juresianum. XLII Reunião Anual da Sociedade Portuguesa de Farmacologia. Lisboa, Fevereiro de 2012.
Mendes AF*, Rosa SC, Judas F, Lopes MC. NF-kB activity is reduced by iNOS-derived NO in human chondrocytes: contribution to sustained low grade inflammation in osteoarthritis. 10th World Congress on Inflammation. Paris, Junho de 2011.
Rufino AT*, Rosa SC, Judas F, Mobasheri A, Lopes MC, Mendes AF. Modulation of ATP-sensitive potassium channels mediates the regulation of GLUT-1 content in human articular chondrocytes: differential role in normal and osteoarthritic human chondrocytes. XLI Reunião Anual da Sociedade Portuguesa de Farmacologia. Coimbra, Fevereiro de 2011.
Prizes and scholarships
Jorge Mineiro” prize for the best research work awarded by the Portuguese Society for Orthopedic Surgery and Trauma to the work entitled “Cryopreservation of human articular cartilage: validation of a large osteochondral model and evaluation of the cryoprotective efficacy of glycerol, dimethylsulfoxide and arbutin” by Fernando Judas, Susana Rosa, Celeste Lopes and Alexandrina F. Mendes. Prize awarded during the XXVII National Congress of Orthopaedics and Trauma, Vilamoura November 14th-16th 2007
Prize DePuy Jonhson & Jonhson for the best poster awarded to the work entitled “Study of chondrocyte viability in fresh and frozen osteochondral allografts: effect of cryoprotective agents” by Fernando Judas, Alexandrina Mendes, Susana Rosa, Celeste Lopes and Adrião Proença. Prize awarded during the XXV National Congress of Orthopaedics and Trauma ,Vilamoura 26th-28th October 2005
NATO scholarship awarded for three short term residencies (9/3rd-12/9th 1996, 9/7th-10/12th 1997 and 7/4th-12/19th 1998) at the Samuel Lununfeld Research Institute, Toronto, Canada, under supervision of Prof. Tony Cruz
Patent
Título: Bioreactor de estímulo para caracterização biomecânica de engenharia de tecidos.
Autores: António Completo, Alexandrina Ferreira Mendes
Patente em Portugal nº 20131000019355
Seminars and conferences (reverse chronological order)
Mendes AF. Farmacoterapia da cartilagem articular. 36º Congresso Nacional da Sociedade Portuguesa de Ortopedia e Traumatologia. Porto, Outubro de 2016.
Mendes AF. Factores de crescimento. Viscosuplementos. Plasma Rico em Plaquetas. “Cartilagem articular – 4ªs Jornadas do Grupo de Estudo da Cartilagem Articular (GECA) e 7º Curso teórico-prático”. GECA, Sociedade Portuguesa de Ortopedia e Traumatologia. Lisboa, Abril de 2016.
Mendes AF. Farmacoterapia da cartilagem: novas guidelines internacionais. “Cartilagem articular – 4ªs Jornadas do Grupo de Estudo da Cartilagem Articular (GECA) e 7º Curso teórico-prático. GECA, Sociedade Portuguesa de Ortopedia e Traumatologia. Lisboa, Abril de 2016.
Mendes AF. Diabetes mellitus as a risk factor for osteoarthritis: modulation of chondrocyte functions by high glucose. Osteoarthritis Therapeutics Conference 2015. Fusion Conferences. Budapeste, Dezembro de 2015.
Mendes AF. Farmacoterapia del cartílago: nuevas guidelines internacionales. 52º Congreso de la Sociedad Española de Cirúrgia Ortopédica e Traumatologia, Valencia, Setembro de 2015.
Mendes AF. Diabetes-induced osteoarthritis: role of hyperglycemia in joint destruction. Workshop “Musculoskeletal Health in the 21st Century”, Institute of Advanced Studies, University of Surrey, Junho de 2015.
Mendes AF. Anti-inflammatory and anti-catabolic activity of natural products in human chondrocytes. 3º Encontro dos Centros de Investigação Nacionais sobre cartilagem. Grupo de Estudo da Cartilagem Articular, Sociedade Portuguesa de Ortopedia e Traumatologia. Lisboa, Novembro de 2014.
Mendes AF. Factores de crescimento e viscosuplementação. “Cartilagem articular – 3ªs Jornadas do Grupo de Estudo da Cartilagem Articular (GECA) e 6º Curso teórico-prático”. GECA, Sociedade Portuguesa de Ortopedia e Traumatologia. Lisboa, Novembro de 2014.
Mendes AF. Farmacoterapia da cartilagem: novas guidelines internacionais. “Cartilagem articular – 3ªs Jornadas do Grupo de Estudo da Cartilagem Articular (GECA) e 6º Curso teórico-prático. GECA, Sociedade Portuguesa de Ortopedia e Traumatologia. Lisboa, Novembro de 2014.
Mendes AF. Influência do estímulo mecânico nas funções do condrócito: implicações para a engenharia de cartilage. Seminário proferido no âmbito do Mestrado em Biomateriais e Dispositivos Biomédicos, Universidade de Aveiro, Outubro de 2014.
Rufino AT, Ribeiro M, Ferreira JP, Bandeiras C, Completo A, Ramos A, Mendes AF*. Mechanical stimulation increases the metabolic activity of chondrocytes in 3D agarose constructs. 5th International Conference on Advanced Nanomaterials, Aveiro, Julho de 2014.
Mendes AF. Osteoartrite associada à diabetes? À descoberta de mecanismos patológicos e alvos farmacológicos. 2º Encontro dos Centros de Investigação Nacionais sobre cartilagem. Grupo de Estudo da Cartilagem Articular, Sociedade Portuguesa de Ortopedia e Traumatologia. Lisboa, Novembro de 2013.
Mendes AF. Factores de crescimento e viscosuplementação. “Cartilagem articular – 2ªs Jornadas do Grupo de Estudo da Cartilagem Articular (GECA) e 5º Curso teórico-prático”. GECA, Sociedade Portuguesa de Ortopedia e Traumatologia. Lisboa, Novembro de 2013.
Mendes AF. Farmacoterapia da cartilagem: novas guidelines internacionais. “Cartilagem articular – 2ªs Jornadas do Grupo de Estudo da Cartilagem Articular (GECA) e 5º Curso teórico-prático. GECA, Sociedade Portuguesa de Ortopedia e Traumatologia. Lisboa, Novembro de 2013.
Mendes AF. Influência do estímulo mecânico nas funções do condrócito: implicações para a engenharia de cartilagem. Seminário proferido no âmbito do Mestrado em Biomateriais e Dispositivos Biomédicos, Universidade de Aveiro, Outubro de 2013.
Mendes AF. Chondrocyte biology and osteoarthritis research. 2º Workshop - “Sinergias e Financiamento ”. Instituto de Investigação Interdisciplinar (IIIUC) & Divisão de Apoio e Promoção da Investigação (DAPI), Universidade de Coimbra. Janeiro de 2013.
Mendes AF. Biologia do condrócito e osteoartrite. 1º Encontro dos Centros de Investigação Nacionais sobre cartilagem. Grupo de Estudo da Cartilagem Articular, Sociedade Portuguesa de Ortopedia e Traumatologia. Lisboa, Novembro de 2012.
Mendes AF. Factores de crescimento e viscosuplementação. “Cartilagem articular – 1ªs Jornadas do Grupo de Estudo da Cartilagem Articular (GECA) e 4º Curso teórico-prático”. GECA, Sociedade Portuguesa de Ortopedia e Traumatologia. Lisboa, Novembro de 2012.
Mendes AF. Farmacoterapia da cartilagem: novas guidelines internacionais. “Cartilagem articular – 1ªs Jornadas do Grupo de Estudo da Cartilagem Articular (GECA) e 4º Curso teórico-prático”. GECA, Sociedade Portuguesa de Ortopedia e Traumatologia. Lisboa, Novembro de 2012
Mendes AF. Influência do estímulo mecânico nas funções do condrócito: implicações para a engenharia de cartilage. Seminário proferido no âmbito do Mestrado em Biomateriais e Dispositivos Biomédicos, Universidade de Aveiro, Outubro de 2012.
Mendes AF. Factores de crescimento e viscosuplementação. “Cartilagem articular – 3º Curso teórico-prático”. Grupo de Estudo da Cartilagem Articular, Sociedade Portuguesa de Ortopedia e Traumatologia. Lisboa, Novembro de 2011.
Mendes AF. Farmacoterapia da cartilagem. “Cartilagem articular – 3º Curso teórico-prático”. Grupo de Estudo da Cartilagem Articular, Sociedade Portuguesa de Ortopedia e Traumatologia. Lisboa, Novembro de 2011.
Mendes AF. Osteoartrite: inevitabilidade ou oportunidade? Seminários de divulgação da investigação. Faculdade de Farmácia, Universidade de Coimbra, Maio de 2011.
Mendes AF. Factores de crescimento. “Cartilagem articular – 2º Curso teórico-prático”. Grupo de Estudo da Cartilagem Articular, Sociedade Portuguesa de Ortopedia e Traumatologia. Lisboa, Novembro de 2010.
Mendes AF. Farmacoterapia da cartilagem. “Cartilagem articular – 2º Curso teórico-prático”. Grupo de Estudo da Cartilagem Articular, Sociedade Portuguesa de Ortopedia e Traumatologia. Lisboa, Novembro de 2010
Mendes AF. Cartilage supplements: glucosamine and chondroitin. 5th International Course of Osteoarticular Reconstruction (RECOA IV). Curia, Abril de 2010.
Mendes AF. Factores de crescimento. “Cartilagem articular – 1º Curso teórico-prático”. Grupo de Estudo da Cartilagem Articular, Sociedade Portuguesa de Ortopedia e Traumatologia. Lisboa, Novembro de 2009.
Mendes AF. Farmacoterapia da cartilagem. “Cartilagem articular – 1º Curso teórico-prático”. Grupo de Estudo da Cartilagem Articular, Sociedade Portuguesa de Ortopedia e Traumatologia. Lisboa, Novembro de 2009.
Mendes AF. Chondrocyte functions and articular cartilage properties. The Prague Arthroscopy Symposium on Cartilage Surgery. Praga, Setembro de 2009.
Mendes AF. Tissue engineered cartilage: sources and challenges of culturing chondrocytes. The Prague Arthroscopy Symposium on Cartilage Surgery. Praga, Setembro de 2009.
Mendes AF*, Rosa SC*. Inflamação e Osteoartrite: Papel do NF-kB e do NO. II Colóquio do Departamento das Ciências Laboratoriais Aplicadas na Saúde. Escola Superior de Tecnologias da Saúde de Coimbra. Coimbra, 31 de Maio de 2008.
Rosa SC, Judas F, Lopes MC, Mendes AF*. The chondrocyte: cartilage designer and builder. First International Consensus Meeting: New Horizons in Cell and Tissue Banking. Vale de Santarém, Maio de 2007.
Mendes AF. Fisiologia da Cartilagem Articular. Congresso anual da Sociedade Portuguesa de Ortopedia e Traumatologia. Porto, Outubro de 2006.
Mendes AF*, Rosa SC. Evaluación de la expresión de las isoformas neuronal y inducible de la síntase del óxido nítrico y su relación con la actividad del NF-kB en condrocítos osteoartríticos. Reunião de constituição do “Grupo del Cartílago”. Sevilha, Março de 2006.
Supervision of Master and PhD thesis
PhD thesis:
Susana Carvalho Rosa (2005-2010)
Ana Teresa Oliveira Rufino (2009-2015)
Cátia Moreira de Sousa (2012-)
Maria Madalena Azevedo Alves Ribeiro (2012-awaiting defense)
João Pedro Oliveira (2013-)
Sara Castendo Ramos (2013-)
Master thesis:
|
Ângela Mara Reis Neves (2008-2009) Isabel Cristina do Vale Ferreira (2010-2011) Mélanie Duarte (2011-2012) |
Ana Maria Alves (2015-2016)
Sylvie Gonçalves (2015-2016)
Reviewer of international I&D projects
National Science Foundation, Estados Unidos da América, 2009
Foundation for Polish Science, Polónia, 2012
Medical Research Council, UK, 2015
Member of the “PhD Thesis Board of Reviewers” of the University of Valencia, Spain, since January 2011.
Editorial activity
Membro do quadro de editores da revista Scientific Reports, FI: 5,578, Q1
Membro do quadro de editores revisores da revista Frontiers in Physiology, FI: 3,534 ; Q1
Membro do quadro de editores da revista BMC Musculoskeletal Disorders, FI: 1,717; Q2
Membro do quadro de editores da revista Journal of Functional Morphology and Kinesiology (1º ano de publicação da revista, sem índice de impacto)
Membro associado da Faculty of 1000Prime, secção de Reumatologia e Imunologia Clínica
Revision of scientific articles
Acta Biomaterialia
Aging
Apoptosis
Arthritis Research & Therapy
Basic & Clinical Pharmacology & Toxicology
BMC Musculoskeletal Disorders
Critical Care Medicine
European Journal of Pharmaceutical Sciences
Free Radical Research
Frontiers in Biosciences
Frontiers in Endocrinology
Frontiers in Physiology
International Immnunopharmacology
Journal of Cellular Biochemistry
Journal of Cellular Physiology
Journal of Membrane Biology
Journal of Orthopaedic Research
Journal of Pharmacy and Pharmacology
Molecular Biology Reports
Molecules
Nitric Oxide: Biology and Chemistry
Ophtalmic Research
Pharmaceutical Biology
Scientific Reports
Therapeutics and Clinical Risk Management
Other activities
Membro do Grupo de Avaliação de Medicamentos Veterinários da Direcção-Geral de Alimentação e Veterinária, desde Maio de 2009.