Drug Development I

Recommended Prerequisites

Not applicable.

Teaching Methods

The course consists of lectures, problem-solving classes and lab classes.

Lectures: presentation of theoretical concepts using audiovisual methods (data-show, etc.), always accompanied by the use of the blackboard, an important tool for discussion because the rate of presentation of topics allows the student to follow more closely the topics. Student participation will be encouraged.

Problem-solving classes: presentation of exercises to be discussed and resolved.

Practical classes: carrying out different projects will allow familiarization with essential lab techniques.

Learning Outcomes

Knowledge and ability to understand
1.Recognize and apply basic concepts and principles in synthesis and drug desing.
1.2. Ability to analyze, synthesize and understand.
Applying knowledge and understanding
2.Learn to apply acquired knowledge in the individual´s vocational area at the professional approach level.
Judgment / decision making
3.Ability to solve problems in synthesis and drug desing.
3.1 Learn to substantiate arguments when making decisions
Communication
4. Understand and know how to use information sources. Ability to search and use bibliography
4.1 Acquire skills for communicating information clearly, with speech and other appropriate means. Acquire skills
in structured presentations of scientific matters to a competent audience, ability to debate, whether orally or in writing.
Skills related to self-learning
5. Have skills which enable self-learning throughout life.

Work Placement(s)

No

Syllabus

Drug discovery: Historical evolution. Dynamics. Casual and directed discovery. Process of design, development and strategies. Identification of therapeutic targets, hits selection, lead identification and optimization, natural and synthetic products. pharmacophore identification. estructural modifications to increase efficacy. New methodologies organic synthesis, microwave-assisted synthesis and combinatorial chemistry. Bioisosterism, optimization of receptor binding. Experimental Design:The problem. Common objectives and procedures. The planning factor 2 ^ k. The main effects and interaction: interpretation. General algorithm. Coding. Better description, more experiences: Less experience: fractional factorial and Plackett-Burman. Administration and properties: Molecular structure, pharmacophores. PKa and solubility. The partition coefficient. The stability of the drug. The binding protein. ADME. Safety. Dissolution. Relevance. Profiles and their description. Comparison

Assessment Methods

Evaluation
Laboratory work or Field work: 20.0%
Exam: 80.0%

Bibliography

Introduction To The Principles Of Drug Design And Action, Smith And Williams’ Third Edition, Ed. H.John Smith,
Welsh School Of Pharmacy, University Of Wales, Cardiff, UK
Chirality in Drug Design and Development, Edited By Indra K. Reddy, Reza Mehvar, U.S.A.
New Drug Development, Design, Methodology and Analysis, J. Rick Turner; B Wiley-Interscience; A John Wiley & Sons, Inc., Publication