Biomaterials, Cell and Molecular Biology, Developmental Biology.
Theoretical classes: oral exposition, using audiovisual support materials and internet access. Theoretical concepts will be accompanied and supported by application examples and case studies.
Laboratorial classes: activities pre-preparation, teaching supervision on laboratorial tasks/procedures. Students organized in groups.
Laboratorial demonstrations on some selected issues, to be performed by teachers with the help of research students. Tutorial supervision for other propoesed tasks and projects. Special seminars will be scheduled which will be presented by specialist guest lecturers.
This course serves as an introductory description and as a critical assessment of the major issues related to Tissue Engineering (TE). Students will acquire the required theoretical knowledge to understand all the involved inter- and multidisciplinary issues (including Engineering) on the improvement, regeneration or replacement of existing/damaged/malfunctioning biological tissues and human organs. The employed perspective considers the mutual interactions between the 3 main pillars of TE: cells, biomaterials and signaling/bioactive substances. Other recent approaches will be also covered such as surface nanotechnology, nanotechnology on the fabrication of TE scaffolds, advanced release systems, cell culture and TE bioreactors. Laboratorial skills will be improved by carrying out of several specific laboratorial activities and by the attendance/participation to other Lab demonstrations.
Theoretical component: introduction to Tissue Engineering (TE): introduction (history and scope, applications, new perspectives and trends); fundamentals of TE (biomaterials, cells and stem cells, signalling; extracellular matrices: structures and functions, cell-biomaterial interactions, cell growth/adhesion/migration, biocompatibility, inflammatory/immune responses); TE scaffolds (required chemical, physical and biological properties, degradation, delivery of signalling/bioactive substances, polymeric, inorganic and composite scaffolds); TE scaffolds fabrication (polymeric, inorganic and composite, nanotechnology on scaffold fabrication); TE bioreactors (introduction, cell culture, bioreactors for specific TE applications, examples).
Laboratorial component: experimental lab works on different course themes will be performed. A mini-research project will be carried out (during the semester). Laboratorial demonstrations will be also performed (by teachers and/or other researchers).
Midterm evaluation test (laboratorial activitivities): 30.0%
B.D. Ratner, A.S. Hoffman, F.J. Schoen, J.E. Lemons, (Eds), Biomaterials Science: An Introduction to Materials in Medicine, 2nd Ed, Academic Press, Elsevier, The Netherlands, 2004
J. Park, R.S. Lakes, Biomaterials. An Introduction, 3rd Ed, Springer Science, NY, USA, 2007
Outra bibliografia poderá ser indicada/fornecida durante as aulas da disciplina/Other bibliographic materials may be provided/indicated during course class.
Lanza, R. Langer, J. Vacanti, (Eds), Principles of Tissue Engineering, 3rd Ed, Academic Press, Elsevier, The Netherlands, 2007
J.P. Fisher, A.G. Mikos, J.D. Bronzino, (Eds), Tissue Engineering, CRC Press, Boca Raton, FL, USA, 2007
C.T. Laurencin, L.S. Nair, (Eds), Nanotechnology and Tissue Engineering, CRC Press, Boca Raton, FL, USA, 2008
A. Atala, R. Lanza, J.A. Thomson, R.M. Nerem, (Eds), Principles of Regenerative Medicine, Academic Press, Elsevier, The Netherlands, 2008
R. Barbucci (Ed), Integrated Biomaterials Science, Kluwer Academic Publishers, NY, USA, 2002