Pathophysiology of Aging

Recommended Prerequisites

Knowledge of pathophysiology mechanisms.  

Teaching Methods

The lectures are grounded in teaching techniques aimed at a teaching / participatory learning:

•Formulation of goals

•Use of handouts

•Structuring the lesson from the analysis of a problem

•Placement of issues which promote the reasoning

•Discussion after exposure

•Brief final summary

The exposure technique of lectures is guided by the theme of the lesson, active / interactive methodology is used whenever possible.

Learning Outcomes

- To know the Theories of Aging, from the past to the present days

- To know the molecular and cellular changes associated with aging , as well as at the organism as a whole

- To know the changes of the inflammatory response in the elderly

- To know the enhancing and modulating factors of the inflammatory response in aging

- To name the biomarkers of aging

Skills:

- Identify the pathophysiology mechanisms of inflammatory pathology in aging

- To analyze the changes of the inflammatory response of the elderly

- Know the therapeutic targets in inflammatory pathology in order to act in of the elderly pathology.

Work Placement(s)

No

Syllabus

Introduction

Theories of Aging - From past to present

• Theory of Free Radicals

• Theory of Injury / Repair of DNA

• Genetics Theory

• Theory of Telomerase

What are the determinants of aging in humans?

• The involvement of sirtuins in aging

• Inflammatory Response and Aging

Favorable factors and modulators of inflammatory markers

• Antigenic Stress

• Obesity - Visceral adiposity and fat diet

• Sex Hormones

• Physical Exercise

Phathophysiologic mechanisms of aging diseases

• Cardiovascular Pathology

• Metabolic Syndrome

• Frailty syndrome and sarcopenia in the elderly

• Neurodegenerative Diseases

Biomarkers of Aging

Inflammatory pathology on Aging: The example of Allergy and Gastrointestinal Pathology.

Assessment Methods

Assessment
Exam: 100.0%

Bibliography

- Mota-Pinto, A; Resende-Oliveira, C. 2014. Biologia e Fisiopatologia do Envelhecimento.  In Geriatria Fundamental. Saber e Praticar, ed. Teixeira Veríssimo, M, 17 - 28. ISBN: 9789897520563. Lisboa: Lidel, Edições Técnicas, Lda.

- Resende-Oliveira, C; Mota-Pinto, A; Rodrigues, V; Botelho, A. 2013. Growing old in Portugal.  In Global Aging Issues and Policies. Understanding the importance of comprehending and studying the aging process, ed. Yushi (Boni) Li, 196 - 209. ISBN: 978-0-398-08866-8. Springfield, Illinois, USA: Charles Thomas - Publishers, Ltd

- Rodrigues, V; Mota-Pinto, A; Sousa, B; Botelho, A; Alves, C; Oliveira Catarina R. 2014. "The Aging Profile of the Portuguese Population: A Principal Component Analysis", Journal of Community HealHealth [Epub ahead of print] 12 Feb 2014, 39: 747 - 752. doi: 10.1007/s10900-014-9821-2

- Sander M, Avlund K, Lauritzen M, Gottlieb T, Halliwell B, Stevnsner T, et al. Aging-From molecules to populations. Mech Ageing Dev. 2008;129:614–623.