Bioelectronics

Recommended Prerequisites

Not applicable.

Teaching Methods

Theoretical - Audiovisual media will be used including the use of PowerPoint, viewing of short videos and other media content.

Practical - Interactive teaching through the discussion of case studies and application of learned subjects to practical ends, such as culturing and assessing cell signals in-vitro.

Learning Outcomes

The student will be able to:

-Develop critical evaluation skills needed for an appropriate and practical understanding of Bioelectronics and Biosensors.

-Understand the state-of-the-art biomaterials used in biosensors.

-Understand concepts of extracellular electrophysiology with focus on cell-device interaction.

-Understand how cells produce electricity

-Understand manufacturing steps of modern bioelectric devices

-Comprehend the ion kinetics involved in cell signalling.

-Critical thinking in assessing solutions to complex tasks.

-Characterize bioelectricity in cells.

-Understand key issues of cell-sensor interactions and cohort signalling.

-Develop competences on critical analysis for effective group work and structured reflection.

-Develop team working skills, report writing skills and presentation skills.

-Communicate to technical and non-technical audiences.

Work Placement(s)

No

Syllabus

1.Cellular bioelectricity:

  a.Membrane structure

    i.Pumps and channels

    ii.Electrical properties of a cell membrane

    iii.Charge flows in electrolytes and across cell membranes, inc. the Neuron Action potential

  b.Resting Potential and intercellular transmission

 

2.Bioelectronic devices:

  a.Biomaterials and biocompatibility

  b.Fundamentals of bio-signal sensing and processing, including analysis tools (MATLAB) and linearity

  c.Microelectrode arrays and systems

 

3.Bioelectronic medical systems:

  a.The human nervous system and clinical neuro- prosthetics

  b.Exemplar neuro- prosthetics for supressing seizures

  c.Drug delivery and testing systems

 

4.Beyond conventional bioelectronics:

  a.Bioelectricity in microorganisms and plants

  b.Emerging applications in environmental sustainability

Head Lecturer(s)

Paulo Roberto Ferreira da Rocha

Assessment Methods

Assessment
Continuous evaluation (e.g. attendance, class participation):: 10.0%
Project: 40.0%
Exam: 50.0%

Bibliography

Bibliografia e webgrafia aconselhada ao longo das aulas.

Outra bibliografia de apoio:

Integrative Action of the Autonomic Nervous System, Wilfrid Janig, ISBN # 9780511541667

Bioelectricity: A Quantitative Approach, Robert Plonsey and Roger C. Barr, ISBN # 978-0387488646

Bioelectromagnetism - Principles and Applications of Bioelectric and Biomagnetic Fields, Jaakko Malmivuo and Robert Plonsey, ISBN # 978-0195058239

MATLAB student edition, or access to a computer with MATLAB

Journal papers:

•Multi-electrode array technologies for neuroscience and cardiology

•https://www.nature.com/articles/nnano.2012.265.pdf

•Peripheral nerve bionic interface: a review of electrodes

•https://link.springer.com/content/pdf/10.1007%2Fs41315-019-00086-3.pdf

Book section:

•Biomaterials Science, An Introduction to Materials in Medicine, 2013, Pages 981-996, Chapter II.5.12 - The Role of Biomaterials in Stimulating Bioelectrodes

•https://www.sciencedirect.com/science/article/pii/B978008087780800084X