Technology of Controlled Release Systems
1
2024-2025
02050229
Pharmaceutical Sciences
Portuguese
Face-to-face
SEMESTRIAL
6.0
Compulsory
2nd Cycle Studies - Mestrado
Recommended Prerequisites
Polymer chemistry; Pharmaceutical Technology; Pharmacokinetics.
Teaching Methods
Master classes with description and illustration of the concepts using slides. Use of multimedia and laboratory part of filming done in FFUC. Formulation based learning. Presentation of scientific articles
Learning Outcomes
- Know and explain the importance of controlled release of drugs:
- Ability to explain the relationship between pharmacokinetics of the drug and design of modified drug delivery systems.
- To know and exemplify the main technologies of preparation of modified-release systems.
- To know and justify the specificity control of modified release systems.
Work Placement(s)
NoSyllabus
Controlled release of drugs; facts and myths; Pharmaceutical Technology of modified drug release systems;
modified release systems for oral delivery, physiologic and physical chemistry impact on pharmaceutical
development; Dosage forms and administration routes; Colon delivery, physiologic and polymers influence.
Head Lecturer(s)
Carla Sofia Pinheiro Vitorino
Assessment Methods
Assessment
Other: 25.0%
Synthesis work: 25.0%
Exam: 50.0%
Bibliography
Cardinal JR. Matrix systems. In Langer RS, Wise DL, editors. Medical Applications of Controlled Release: Classes of Systems, Vol. 1, CRC Press, Boca Raton, FL, 1984, pp. 41–67.
Siepmann, J., Siepmann, F., 2012. Swelling Controlled Drug Delivery Systems, in: Siepmann, J., Siegel, R.A., Rathbone, M.J. (Eds.), Fundamentals and Applications of Controlled Release Drug Delivery. Springer US, pp. 153-170.
Sousa, A.S., Serra, J., Estevens, C., Costa, R., Ribeiro, A.J., 2022. A quality by design approach in oral extended release drug delivery systems: where we are and where we are going? J. Pharm. Investig.53:269-306.
Tu, J., Shen, Y., Mahalingam, R., Jasti, B., Li, X., 2010. Polymers in Oral Modified Release, in: Wen, H., Park, K. (Eds.), Oral Controlled Release Formulation Design and Drug Delivery: Theory to Practice, 1st Edition ed. John Wiley & Sons, New Jersey, pp. 71-87.