Physics of Pharmaceutical Systems

Recommended Prerequisites

Related knowledge (Physical-Chemistry, Pharmaceutical Technology, Instrumental Methods of Analysis, Biopharmacy and Pharmacokinetics); generic skills (analysis and synthesis, information management, problem solving, critical reasoning, autonomous learning, application of theoretical knowledge in practical problem solving and ability to investigate in groups); specific skills (know the physicochemical and kinetic mechanisms present in the release of drugs from pharmaceutical forms and understand the technological variables that allow modulating drug release; solid state chemistry-polymorphism and binary and ternary systems). As linguistic competence, the domain of Portuguese and English in order to fulfill the objectives defined by the curricular unit.

Teaching Methods

Theoretical classes

Presentation method by slides and videos

Interpretation and discussion of practical cases in interactive mode

Assessment: Exam (100% of final grade)

Learning Outcomes

Know the compression cycle and its control in equipment for the production of solid forms (tablets); know crystallization as a unitary operation and polymorphism; multicomponent systems and dispersed systems; solid-liquid phase diagrams.

• Understand the experimental conditions to generate polymorphs and co-crystals. Identify and characterize polymorphs and co-crystals using Instrumental methods of analysis.

• Identify colloidal systems and their composition as drug vectors.

• Build solid-liquid phase diagrams from experimental data and show their contribution to the system's characterisation.

• Simulate theoretical curves in the construction of phase diagrams.

• Apply theoretical concepts to the resolution of practical cases, resorting to the integration of knowledge from related curricular units (Physical-Chemistry, Instrumental Methods of Analysis and Pharmaceutical Technology)

Work Placement(s)

No

Syllabus

1. Compression Physics (compression: compression and consolidation; factors that affect compaction: particle size, porosity, presence of binders, elastic, plastic or brittle behavior and compression force; transducers and types; compression cycles force/time; force measurement and recording; plasticity index; Porosity variation; Heckel equation).

2. Crystallization and Polymorphism (Nucleation and crystalline growth; polymorphism: monotropic and enantiotropic systems; methods of studying polymorphism; examples of assets that show the property of polymorphism).

3. Study of multicomponent solid forms (co-crystals: introduction, design and synthesis of co-crystals, methods of preparation of co-crystals, identification and characterization of co-crystals and Impact of co-crystals in the Pharmaceutical Industry).

4. Dispersed Systems (classification, colloidal dispersion, stability, examples of colloidal systems).

5. Contribution of solid-liquid phase diagrams

Head Lecturer(s)

Carla Sofia Pinheiro Vitorino

Assessment Methods

Assessment
Exam: 100.0%

Bibliography

1. Vila Jato José Luis; Tecnología farmacéutica. ISBN: 84-7738-539-4

 2. Gerbino Philip; Remington: the science and practice of pharmacy. ISBN: 0-7817-4673-6

 3. Amidon, Gregory E; Akseli, Ilgaz; Goldfarb, David;He, Xiaorong; Sun, Changquan C Proposed New USPGeneral Information Chapter “Tablet Compression Characterization <1062>,” Pharmacopeial Forum 40(4). (2014).

 4. Hsien-Hsin Tung, Edward L. Paul, Michael Midler, James A. McCauley, Crystallization of Organic Compounds: An Industrial Perspective, john Wiley & Sons, Inc, Hoboken, New Jersey, USA. (2009).

 5. Joel Bernstein, Polymorphism in Molecular Crystals, Clarendon Press, Oxford, New York. (2010).

 6. Mouritsen, O. G. Life - As a matter of Fat. The emerging science of lipidomics; Springer Verlag: Berlin .( 2005).

 7. Edward R.T. Tiekink and Julio-Z.-S. (eds.) Multi-component Crystals: Synthesis, Concepts, Function, De gruyter, Berlin, Germany. (2018).