Radiopharmaceuticals

Recommended Prerequisites

The recommended prerequisites include what is taught in the 1 st cycle courses in the area of Pharmacy, Medicine, Chemical Sciences, Biochemistry, Bioanalytical and Medical Sciences, and other courses considered appropriate by the Master Coordination Board.    

Teaching Methods

A theoretical methodology will be adopted which appeals for the students’ participation to acquire the knowledge, skills and competences defined so that they can be put into practice and a theoretical-practical methodology that focus on the application of the acquired knowledge to practical examples in radiopharmacy.

Learning Outcomes

The student must acquire the fundanental knowledge about the radiopharmaceuticals used in the medical practive and in the research context as well as the risks and legal regulations applicable.

Work Placement(s)

No

Syllabus

• Introduction to Radiopharmacy. Fundamental principles. Basic notions about Radiopharmaceuticals.
• Radiopharmaceuticals in Conventional Nuclear Medicine. Diagnosis vs. therapy. Types of formulations. Molybdenum-technetium generator. Technetium-99m chemistry. Properties of chelates and bio-conjugates. Labeling of antibodies and peptides. Cell labelling.
• Radiopharmaceuticals labeled with Positron Emitters. Clinical and research applications.
• Quality control of radiopharmaceuticals. Conventional vs PET. Current Good Radiopharmaceutical Practices.
• National and nternational regulations. Aseptic production. Organization of a production unit. Validation, documentation and archive. 

Head Lecturer(s)

Carla Sofia Pinheiro Vitorino

Assessment Methods

Assessment
Exam: 100.0%

Bibliography

Saha, Gopal B. (2018). Fundamentals of Nuclear Pharmacy. Springer-Verlag. Seventh Edition.

Theobald, Tony (2010), Sampson's Textbook of Radiopharmacy. Pharmaceutical Press. Fourth edition;

Handbook of Radiopharmaceuticals: Radiochemistry and Applications (2005). Michael J. Welch (Ed). Wiley.

Abrunhosa, Antero and Prata, Maria (2010). Radiopharmaceuticals: Development and Main Applications. in Nuclear Medicine Physics. Pedroso de Lima, J.J. (Ed.). CRC Press;