Risks and interactions

Recommended Prerequisites

Student must have knowledge on Organic Chemistry and Biochemistry, as well on the principles of Pharmacology, Pharmacokinetics and Toxicology.

Teaching Methods

Theoretical, and in real context resolution of clinical cases.

Learning Outcomes

The students should know methods for hazard evaluation, for example, DNA adducts, genotoxicity, mutagenicity, and risk assessment for other potential toxic effects, even if in certain cases for herbal traditional medicines, with well-stablished use, they will be not necessary. These warnings will help to avoid accidents due to a poor evaluation of the potential risks.

In addition, they wil be able to evaluate the potential pharmacodynamic and pharmacokinetic drug-herb interactions  (drugs, herbal medicines, foods, and dietetic supplements) which induce events of therapeutic failure, toxicity events, and, also, side effects and toxicity from adulterants and/or contaminants). The main focus will be chronic and oncologic diseases). At the end of this learning, the students will be able to discuss the borderline outcomes from the confirmative results and provide the necessary tools for a better and more rational risk assessment assuring the safety of herbal-based medicine.

Work Placement(s)

No

Syllabus

Legal regulatory guidelines for safety assessement of herbal based drugs.

Theoretical concepts of Pharmacodinamic and Pharmakinetic interactions.

Case reports and Clinical cases for resolution.

Assessment Methods

Assessment
Resolution Problems: 50.0%
Mini Tests: 50.0%

Bibliography

Francis Brinker -Herbal Contraindications and Drug Interactions: Plus Herbal Adjuncts with Medicines, 4 ed. st Edition

Y. W. Francis Lam, Shiew-Mei Huang, Stephen D. Hall. Herbal Supplements-Drug Interactions. Scientific and Regulatory Perspectives. Ed Francis Lam, Shiew-Mei Huang, Stephen D. Hall. 2006

Williamson et al.. Ed. E. Williamson. Stockley's Herbal Medicines Interactions. A guide to the interactions of herbal medicines, RPS, UK, 2013