Processes and Technologies applied to the manufacture of herbal preparations

Recommended Prerequisites

It is recommended that the student has knowledge about the microstructure of plant tissues and phytochemistry and about the chemical principles associated with the physics of intermolecular interactions.

Teaching Methods

Lectures complemented with theoretical-practical exercises and illustration with real cases. 

Learning Outcomes

It is intended that students acquire knowledge to understand the principles of the preparation and stabilization of plant material, the physico-chemical basis of mass transfer processes from heterogeneus complex matrices (plant tissues) and acquire skills to plannify industrial processes for herbal preparations, herbal medcines and nutraceuticals in compliance with the good manufacture practices (GMPs) and quality guidelines.

It is also intended that they acquire knowledge about the official and physical characteristics of pharmaceutical dosage forms for oral administration, nasal administration and cutaneous application and on their formulation, in regard the specificities of the herbal ingredients and their stability.

Work Placement(s)

No

Syllabus

1- Herbal preparations: concepts and regulatory framework in the context of herbal medicines and nutraceuticals.

2. Stabilization of plant matrices.

3- Mass transfer processes from heterogeneous solid matrices (plant tissues):

3.1- Physical-chemical fundamentals of solid/vapor mass transfer.

3.1.2- Distillation processes.

3.2- Physical-chemical fundamentals of solid-liquid mass transfer.

3.2.1- Solid/liquid mass transfer processes in the production of herbal preparations: static and dynamic processes;

3.2.2- Optimization of mass transfer and scaling-up strategies.

4. Stabilization and conservation processes of extracts.

5. Fractionation.

6. Formulations with active ingredients of plant origin: herbal substances and liquid and solid herbal preparations. 7. Stability and compliance of herbal medicines and nutraceuticals made of herbal substances or preparations. 

Assessment Methods

Assessment
Synthesis work: 30.0%
Exam: 70.0%

Bibliography

Shariati et al., Preparation of Phytopharmaceuticals for the Management of Disorders. The Development of Nutraceuticals and Traditional Medicine, Chp 5 - Herbal drug technology.

Milan Hait,  Extraction Techniques of Herbal Drugs, In Research Trends in Medicinal Plant Sciences (Vol 5) AkiNik Publications, October 2019  10.22271/ed.book.415

Handa SS et al. Extraction Technologies for Medicinal and Aromatic Plants. INTERNATIONAL CENTRE FOR SCIENCE AND HIGH TECHNOLOGY Trieste, 2008

European Medicines Agency, Guideline on declaration of herbal substances and herbal preparations in herbal medicinal products/traditional herbal medicinal products. Committee on Herbal Medicinal Products (HMPC) Committee for medicinal products for human use.EMA/HMPC/CHMP/CVMP/287539/2005

ISO/FDIS. Aromatic natural raw materials — Vocabulary. INTERNATIONAL STANDARD ISO9235

Word Health Organization. WHO guidelines on good herbal processing practices for herbal medicines WHO Technical Report Series 1010, 2018.