Cellular and Molecular Mechanisms of Disease

Recommended Prerequisites

First Cycle in Biology or Biochemistry or other area of Life Sciences, or  basic knowledge of Cell Biology, Molecular Biology, Physiology and Biochemistry.

Teaching Methods

Theoretical classes with the presentation\explanation\discussion of cutting-edge topics in the area.

In theoretical-practical classes students will discuss articles \ cutting-edge topics in the field. Elaboration of a scientific research project written and present \ defend in oral presentation to all students of the edition (panels shall be appointed for this purpose, among the students of the discipline).

The laboratory standpoint it is intended that students use knowledge prior to performing an autonomous work, including planning of experiments, obtaining and critical discussion of results.

Learning Outcomes

Concepts, methodologies and strategies that are used both in theoretical,  either in the practical component of this course, allow the understanding of the relationship between pathological and molecular basis of and processes in several diseases.

Work Placement(s)

No

Syllabus

Introduction to Mechanisms of Human Disease

Metabolism regulation and disease

Mitochondrial Biology and Cell Death Pathways

Mitochondrial diseases

Aging and mitochondria

Mitochondria and cancer

Ischemia/reperfusion: mechanisms of tissue injury

Mechanism of liver regeneration

Obesity; Diabetes Mellitus

Metabolic Syndrome

Atherosclerosis and Coronary Artery Disease

Diseases of the brain. Neuroprotective strategies.

Assessment Methods

Assessment
Exam: 50.0%
Project: 50.0%

Bibliography

Basic Medical Biochemistry. A Clinical Approach (5th edition), Alisa Peet and Michael Lieberman (Eds.), Wolters Kluwer, Philadelphia (2018)

Mitochondria in Health and Sickness, Andrea Urbani, Mohan Babu. (Eds.), Springer, USA (2019)

Robbins&Cotran Pathologic Basis of Disease (Tenth Edition), Kumas, Abbas and Aster (Eds.) Elsevier, Philadelphia (2020).