Identification and Analysis of Organic Compounds

Year
1
Academic year
2023-2024
Code
02005732
Subject Area
Chemistry
Language of Instruction
Portuguese
Mode of Delivery
Face-to-face
Duration
SEMESTRIAL
ECTS Credits
5.0
Type
Compulsory
Level
2nd Cycle Studies - Mestrado

Recommended Prerequisites

Basic knowledge of spectroscopy and organic chemistry.

Teaching Methods

The teacher should present topics with updated information based on his experience as a researcher. Some scientific studies developed by the teacher can be discussed when they fall in the syllabus content. A topic will be given to be presented with an oral discussion. In this way the student will be followed more closely. A theme within the subject content of the curricular unit will also be presented on which the student must submit a written review.  

Learning Outcomes

 Knowledge and ability to understand

-  Recognize and apply basic concepts and principles which allow the interpretation of spectra of organic compounds.

-  Ability to analyze, synthesize and understand.

Applying knowledge and understanding

-  Learn to apply acquired knowledge in the individual´s vocational area at the professional approach level.

Judgment / decision making

-  Learn to substantiate arguments when making decisions

Communication

-  Understand and know how to use information sources. Ability to search and use bibliography

-  Acquire skills for communicating information clearly, with speech and other appropriate means.

-  Acquire skills in structured presentations of scientific matters to a competent audience, ability to debate, whether orally or in writing.

Skills related to self-learning

-  Have skills which enable self-learning throughout life.   

Work Placement(s)

No

Syllabus

 Nuclear Magnetic Resonance Spectroscopy

Perturbation of the total magnetization vector. Relaxation times

Chemical Shift

Chemical shift for protons and carbon thirteen

Anisotropic effects

Shift Reagents

Nuclear Spin Coupling

Proton coupling; Factors affecting the value of J

Deviations from the 1st order model

AB, ABX, ABMX and AA'BB' Systems

Spin Decoupling

Solvent Anisotropy Effect

Coupling with 13C

Nuclear Overhauser Effect

Molecular Movements

Intramolecular and Intermolecular Chemical Processes

Experiments Using Multiple Pulses

APT - Attached Proton Test

Polarization Transfer Methods: INEPT, DEPT

Measuring relaxation times

Bidimensional Spectra

COSY, INADEQUATE, HETCOR, HMQC, HSQC, HMBC, NOESY

Fundamentals of mass spectrometry

Ion Production: Chemical ionization, electron impact, FAB, electrospray

Detection and Analysis of Ions: abundance, fragmentation

Hyphenated techniques: GC-MS and LC-MS

UV / Visible and Infrared spectroscopies.   

Head Lecturer(s)

Teresa Margarida Vasconcelos Dias de Pinho e Melo

Assessment Methods

Assessment
Synthesis work: 25.0%
Exam: 75.0%

Bibliography

  “Spectrometric Identification of Organic Compounds”, R. M. Silverstein, F. X. Webster, D. J. Kiemle, John Wiley & Sons, Inc., 2005.

"Spectroscopic Methods in Organic Chenistry", Dudley H. Williams e Ian Fleming,  McGraw-Hill Book Company, London, 1989.

"Spectroscopic Methods in Organic Chemistry", M. Hesse, H. Meier, B. Zeeh, Georg Thieme Verlag Stuttgart, 1997.

“Espectroscopia de Ressonância Magnética Nuclear”, António M. D'A. Rocha Gonsalves, Teresa M- V. D. Pinho e Melo, Imprensa da Universidade de Coimbra, 2007

"Espectroscopia Electrónica e Vibracional", António M. d’A. Rocha Gonsalves, M. Elisa da Silva Serra, Marta Piñeiro, Imprensa da Universidade, Coimbra, 2005.