Biostatistics

Recommended Prerequisites

Not applicable.

Teaching Methods

A theoretical class will include (1):  a concise review of the material to be covered and its links to previous classes. A theoretical and conceptual analysis is then provided. The next phase (2)  is oriented towards problem based learning using practical examples in the field of Neurosciences.

Learning Outcomes

This teaching module provides integrates quantitative methods in basic, preclinical research and evidence based medicine, with an emphasis on the relevance of association and causality in Biomeedicine. It focuses on examples and quantitative Methods on Fundamental, Pre-clinical and Translational Research. In this first block, the student also learns to understand how biostatistical methods can be used to infer population characteristics based on appropriate samples. 

Work Placement(s)

No

Syllabus

Statistical inference, in particular hypothesis testing, will be emphasized.  Definition of critical p values in relation to the compromise between different types of errors. and  extension to analysis of variance and regression methods.

Descriptive Statistics

Sampling approaches.

Statistical Inference

Probability, risk and odds

Estimation of Confidence Intervals

Sample based estimation of the difference of parameter values across distinct populations.

Hypothesis testing for differences across two groups

Hypothesis testing for the ratio across two groups

Hypothesis testing for the equality of proportions across two groups: chi-square tests

Measuring association between two variables

Measuring concordance

Linear regression

Analysis of variance.

Head Lecturer(s)

Otília da Anunciação Cardoso d'Almeida

Assessment Methods

Assessment
Exam: 100.0%

Bibliography

1. Referências Bibliográficas

• Bernard Rosner Fundamentals of Biostatistics 2006 Thomson Brooks/Cole 868 p ISBN:0534418201

• Daly & Bourke Interpretação e aplicações da estatística em Medicina Ed. Instituto Piaget, 2000

• Massad, Menezes, Silveira & Ortega Métodos Quantitativos em Medicina    ed. Manole, 2004.

• Betty Kirkwood and Jonathan Sterne Essential Medical Statistics Publisher: Wiley-Blackwell; 2nd Edition edition (8 May 2003)

• David Machin, Michael J. Campbell The Design of Studies for Medical Research  ISBN: 978-0-470-84495-3, 286 pages February 2005, ©2005

• Artigos de biomedicina - Versões pdf disponibilizadas pelo corpo docente

2. Aplicações informáticas, bem como os recursos e equipamentos a utilizar

SPSS