Foundations of Molecular and Cell Biology of Cancer and Radiobiology
2nd Cycle Studies - Mestrado
Basic knowledge of Biology.
Theoretical classes with presentation \ explanation \ discussion of cutting-edge topics in the area. Classes are supported by presentations with simple texts and diagrams, graphics.
This course unit aims at doting students with knowledge and skills in molecular and cell biology, oncobiology and radiobiology, particularly with regard to the understanding of: 1) the molecular and cellular mechanisms governing cellular proliferation, differentiation and function; 2) oncogenesis and the hallmarks of cancer; 3) the radiation effects on normal and tumour cells; 4) the cellular response to radiation; 5) the biological effects and models of radiation therapy regimens; 6) the effects of radiotherapy in normal tissues and their impact on treatment; 7) mathematical modelling of treatment results. It is expected that, at the end of this course unit, the students will be able to understand the mechanisms involved in the response of cells to radiation, the way tumour features impact radiation therapy, and how these features may be explored to augment the response to radiation; as well as the physics and biological models that are used in radiation therapy.
Anabela Pinto Rolo
Lodish H, Berk A et al., Molecular Cell Biology 7th ed. New York: W. H. Freeman; 2012
Kumar V, Abbas AK, Aster AC, Robbins & Cotran Pathologic Basis of Disease, 9th ed. Saunders Elsevier; 2015
Robert A Weinberg, The Biology of Cnacer, 2nd ed., Garland Science, 2014
Eric J Hall & Amato J Giaccia, Radiobiology for the Radiologist, 7th ed., Wolters Kluwer, 2011.