Research in Oncobiology

Recommended Prerequisites

Graduation in Health Sciences or related subject.

Teaching Methods

Theoretical (T), T and pratical, lab work and seminar.

Learning Outcomes

Our goal through the PhD program in “Biological diagnosis, Imaging and Therapeutic advances in cancer patient´s management - From Bench-to-Bedside”, is to provide a good interdisciplinary training to help students in their careers of research scientists in the field of cancer therapeutic approaches and translational clinical oncology research.

Educational objectives: Acquisition of  knowledge about (1) Conventional anticancer therapies and Paliative Care (2) Cancer Pharmacology, Biology of Drug Resistance and Response (3) Hormonal Treatment of Cancer (4) New therapeutic approaches in Cancer (Targeted Therapy, Drug delivery, photodynamic therapy, Genetic and immune therapy and Cell based therapy (5) The role of clinical trials in drug development, 6) molecular mechanisms of cancer and tumorigenesis.

Work Placement(s)

No

Syllabus

1. Clinical Management of Cancer - The shift from the past to the future modern oncology.

          Screening, individualized prevention and early cancer detection

          Basic Principals of Cancer Therapy

          Radiotherapy – Applications and new approaches in Cancer

         Translational pharmacogenomics and pharmacoepigenomics - Future challenges of cancer therapy

 2. Cancer Therapy

         Cancer Pharmacology: Drug Metabolism, Transport, and Biodistribution

         Biology of Drug Resistance and Response – clinical applications

 3. Personalized Targeted therapy in cancer: winning the battle and paradigm shift.

         Targeted Therapy – an overview

          Photodynamic therapy – new insights in cancer

          DNA repair and cancer: Therapeutic opportunities and challenges

 4. Hormonal Therapy of Cancer

5. Palliative Care in Oncology

6.  Nanotechnology in cancer management - Drug delivery and gene therapy

7. Cell Based Therapy in Oncology.  

Head Lecturer(s)

Célia Maria Freitas Gomes

Assessment Methods

Assessment
Laboratory work or Field work: 20.0%
Project: 30.0%
Exam: 50.0%

Bibliography

Scientific papers published in international scientific  journals with peer-review

Cancer, Principles & Practice of Oncology – Vicent T. DeVita, Jr, Theodore S. Lawrence, Steven A. Rosenberg, Lippincott Williams & Wilkins (8th Edition), Philidelphia, 2008

Clinical Oncology – Martin D. Abeloff, James O. Armitage, John E. Niederhuber, et al., Elsevier Churchill Livingstone (3rd Edition), Philadelphia, 2004

Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics  - Lauren Pecorino, Oxford University press (2nd Edition), UK, 2008.

Targeted Therapies in Oncology. Ed Giaccone Giuseppe and Jean-Charles Soria, Informa healthcare, 2007.

Targeted Therapies in Cancer: Myth or Reality? Advances in Experimental Medicine and Biology, vol 610. Ed Francesco Colotta and Alberto Mantovani, Springer 2010.

Targeted Cancer Therapy (Current Clinical Oncology) by Razelle Kurzrock and Maurie Markman, Humana press, 2009

Selected scientific articles