Clinical Micology

Recommended Prerequisites

Clinical Biochemistry, Pathophysiology, Immunology, Cellular and Molecular Biology, Clinical Microbiology and Clinical Parasitology.

Teaching Methods

Theoretical classes are not compulsory and are based on the traditional model of knowledge transmission, with electronic presentations illustrating the syllabus. Laboratory classes are mandatory and correspond to the execution of experimental protocols that lead to the diagnosis of a fungal disease and validation of the results obtained. Lesson plans with the identification of activities to be developed as well as didactic material (tutorial type) are provided in advance to students.

Learning Outcomes

1. Promote the acquisition of solid knowledge in the main aspects of Clinical Mycology:

a) Isolation and identification of pathogenic fungi;

b) Taxonomy of fungi;

c) Superficial and invasive fungal infections;

d) Pathogenicity;

e) Epidemiology and evolution of the spectrum of mycoses;

f) Antifungal chemotherapy;

g) Mechanisms of resistance to antifungal drugs

h) Laboratory diagnosis of fungal infections: conventional, immunological and molecular.

2. Provide the student with skills to develop the best laboratory practices in the field of diagnosis in Clinical Mycology.

3. Contribute to the development of skills in understanding published scientific results in order to apply them in the practice of Clinical Mycology

Work Placement(s)

No

Syllabus

1. Introduction to Mycology

2.Fungal diseases. Changing patterns of fungal infection. Predisposition factors for invasive fungal infections.

3. Diagnosis of fungal infections. Conventional, immunological and molecular evaluation

4. Introduction to the principles and practices of antifungal therapy and prophylaxis: Potential targets and mechanisms of action of antifungal agents; Resistance mechanisms; Tests to assess susceptibility to antifungals

5. Main human mycoses: Superficial mycoses; Subcutaneous mycoses; Systemic mycoses by opportunistic fungi; Mycoses in HIV+/AIDS patients; Systemic mycoses by dimorphic fungi.

laboratory practice

1. Mycology Laboratory: organization, material, equipment, rules of behavior and handling

2. Identification of unicellular fungi

3. Identification of filamentous fungi

4. Laboratory diagnosis of fungal infections

5. Application of in vitro of susceptibility tests.

Head Lecturer(s)

Maria do Céu Rodrigues de Sousa

Assessment Methods

Assessment
Exam: 100.0%

Bibliography

Barroso, H., Meliço-Silvestre, A, Taveira, N. 2014. Microbiologia Médica vol 2. Lidel Ed., Lisboa

Deacon, J.W., Modern Mycology, 3rd Edition. Blakwell Science, Oxford, 2000.

Esteves, J. A., Cabrita, J. D., Nobre, G. N., Micologia Médica, 2ª Edição. FundaçãoCalousteGulbenkian, Lisboa, 1990.

Ferreira, W. F. C. e Sousa, J. C. F.,In Microbiologia, Volume 2, 291-343. Lidel Ed., Lisboa, 1998.

Ferreira, W.F.C., Sousa J.C.F., Lima N. 2014. Microbiologia Médica. vol. 1 e 2. Lidel Ed

Kwong-Chung, K. J., Bennett, J. E., Medical Mycology. Lea & Febiger, Philadelphia, 1992.

Murray, P.R., Rosenthal K.S., Pfaller M.A. 2006. Microbiologia Médica. Tradução da 5th Ed, Elsevier Ed

Patterson, T., Fungal Infections, an Issue of Infectious Disease Clinics, 1st Edition. Elsevier B.V, 2006.

Richardson, M. D. & Warnock, D., Fungal infection. Diagnosis and Management, 3rd Edition. Blakwell Publishing, Oxford, 2003.

Webster, J. and Weber, R. W. S., Introduction to Fungi, 3rd Edition. Cambridge University Pr