Drug Monitoring in Personalized Pharmacotherapy

Recommended Prerequisites

General Pharmacology and Pharmacology I.

The student must be able to read in english and spanish.   

Teaching Methods

Theoretical classes will consist of oral presentations regarding the subjects, integrating pedagogical methodologies (such as debates, inverted teaching and minds maps) that encourage the active participation of the student in the learning process and motivate him.

With practical classes, the student will be able to individually solve practical cases of the clinical reality, using a calculator or software. Most lessons will require the use of computers and will include practical problems and clinical cases that the student must investigate to acquire autonomous critical skills.

Learning Outcomes

This curricular unit has a high interest for pharmaceutical activity, both at the hospital and at the ambulatory levels. In the end, students will acquire theoretical and practical knowledge that will allow them to promote the correct use of drugs, through the individualization and optimization of the dosing regimens  to guarantee an effective and safe pharmacotherapy.

After this curricular unit, students should:

- Recognize the factors that contribute to inter- and intra-individual variability in drug efficacy and safety

- Predict the effect of physiopathological and genetic characteristics on drugs pharmacokinetics and pharmacodynamics;

- Be able to calculate the pharmacokinetic parameters and use them to individualize/optimize the dose and the dose interval;

- Apply different techniques and softwares for monitoring and dosage individualization;

- Delineate and optimize therapeutic dosage regimens. 

Work Placement(s)

No

Syllabus

Drug plasma concentration monitoring in clinical practice: concepts, objectives and justification; therapeutic range and impact of intra- and inter-individual variability on the pharmacological response; relevance in personalized pharmacotherapy.

Drug monitoring methodologies and methods of dosage individualization.

Influence of physiological (age, sex, weight, pregnancy), pathological factors (hepatic, renal, cardiac, cancer patients) on the safety and efficacy of drugs.

Pharmacogenetics/pharmacogenomics: influence of genetic factors on drug safety and efficacy (genetic variability in metabolic enzymes and transporters,…).

Influence of clinical factors on drug safety and efficacy: pharmacological interactions, fluid therapy, mechanical ventilation.

Translation into the clinical scenario (drug monitoring/individualization/dosing correction):antiepileptics, antipsychotics, antibacterial drugs and direct oral anticoagulants

Head Lecturer(s)

Ana Cristina Bairrada Fortuna

Assessment Methods

Assessment
Frequency: 50.0%
Resolution Problems: 50.0%

Bibliography

BAUER L. Applied Clinical Pharmacokinetics 3rd Ed. McGraw-Hill. 2014

BURTON E, SHAW LM, SCHENTAG JJ, EVANS WE. Applied Pharmacokinetics & Pharmacodynamics. Principles of Therapeutics  Drug  Monitoring.  4ªEd, Philadelphia, Lippincott Williams & Wilkins 2006.

STRACHAN T, READ A. "Pharmacogenetics, personalized medicine and population screening" in Human Molecular Genetics. 4^th Ed, Garland Science, 2011.

DIPIRO JT. Concepts in Clinical Pharmacokinetics. Fifth Ed. American Society for Health System Pharmacists. 2010.

WINTER M.E. Basic Clinical Pharmacokinetics. 5th Ed, Williams & Wilkins 2010.

Bibliografia complementar fornecida pelo Professor da unidade curricular (Capítulo de Livros, Guidelines Internacionais e Artigos científicos)