Nanobiomaterials

Recommended Prerequisites

Biomaterials.

Teaching Methods

Theoretical classes: oral exposition, using audiovisual support materials and internet access. Theoretical concepts will be accompanied and supported by application examples and case studies. Laboratorial classes: activities pre-preparation, teaching supervision on laboratorial tasks/procedures. Students organized in groups. Laboratorial demonstrations on some selected issues may be organized (teachers/research students). Tutorial supervision for other proposed tasks. Special seminars will be organized (delivered by specialist guest lecturers).

Learning Outcomes

This course serves as an introductory description and as a critical assessment of the major issues related to the use of Nanotechnologies on the development of more efficient and innovative pharmaceutical and biomedical applications. By using structure-size-property-application relationships, students will acquire the required theoretical knowledge to understand all the involved inter- and multidisciplinary issues associated to the synthesis and development of nanostructured biomaterials for uses as nanomedicines, diagnostic/theranostic systems (in vivo, in vitro, POC's), and implantable materials/devices (biodegradable/non-biodegradable). Other relevant topics will be covered: functionalization/bioconjugation of nanobiomaterials (bulk/surface), smart and stimuli-responsive nanobiomaterials, nanometrology, nanotoxicity, and regulation and translation to the clinic. Laboratorial skills will be improved.

Work Placement(s)

No

Syllabus

Theoretical component: introduction to nanobiomaterials; development of nanobiomaterials (current applications, nanostructured materials used in pharmaceutical/biomedical applications; micro-, meso- and macroporous structures; nanostructured surfaces; synthesis examples of polymeric, metallic, inorganic, hybrid and composite nanobiomaterials; functionalization/bioconjugation of nanobiomaterials; smart and stimuli-responsive nanobiomaterials;examples of specific applications (pharmaceutical/diagnostic/theranostic applications, and implantable materials/devices - biodegradable/non-biodegradable); nanometrology and nanotoxicity; regulation and translation to the clinic; regulatory frameworks - FDA/EMA; commercialized products).

Laboratorial component: laboratorial skills will be developed (silica and mesoporous silica NPs; functionalization of silica NPs; silver (or gold), chitosan NPs; magnetic NPs; liposomes; nanostructured aerogels. Lab demonstrations and seminars will be organized.

Head Lecturer(s)

Hermínio José Cipriano de Sousa

Assessment Methods

Assessment
Laboratory work or Field work: 30.0%
Exam: 70.0%

Bibliography

Wang, X, et al, (Eds), Nanobiomaterials. Classification, Fabrication and Biomedical Applications, Wiley-VCH, 2018

Narayan, R, (Ed), Nanobiomaterials. Nanostructured Materials for Biomedical Applications, Woodhead Publishing, Elsevier, 2018

Sharma, AK, et al, (Eds), Nanobiomaterials. Applications in drug delivery, Apple Academic Press, 2021

Collins, AM, Nanotechnology Cookbook: Practical, Reliable and Jargon-free Experimental Procedures, Elsevier, 2012

Jana, NR, Colloidal Nanoparticles: Functionalization for Biomedical Applications, CRC Press, 2019

Hermanson, GT, Bioconjugate Techniques, 3rd Ed, Academic Press, 2013

Liu, Y, Toxicity of manufactured nanomaterials, Particuology, 69, 31-48, 2022

Foulkes, R, et al, The regulation of nanomaterials and nanomedicines for clinical applications, Biomater. Sci., 8, 4653, 2020

Theisz, V, Medical Device Regulatory Practices. An International Perspective, CRC Press, 2016

Min, Y, et al, Clinical Translation of Nanomedicine, Chem. Rev., 115, 11147, 2015