Nanobiomaterials

Recommended Prerequisites

Polymer Science and Technology, Biomaterials

Teaching Methods

Theoretical classes: oral exposition, using audiovisual support materials and internet access. Theoretical concepts will be accompanied and supported by application examples and case studies.

Laboratorial classes: activities pre-preparation, teaching supervision on laboratorial tasks/procedures. Students organized in groups. Laboratorial demonstrations on some selected issues may be organized (teachers/research students). Tutorial supervision for other proposed tasks. Special seminars may be organized (delivered by specialist guest lecturers).

Learning Outcomes

This course serves as an introductory description and as a critical assessment of the major issues related to the use of Nanotechnologies on the development of more efficient and innovative pharmaceutical and biomedical applications. By using structure-size-property-application relationships, students will acquire the required theoretical knowledge to understand all the involved inter- and multidisciplinary issues associated to the development of nanostructured biomaterials for uses as nanomedicines, diagnostic/theranostic systems (in vivo, in vitro, POC's), and implantable materials/devices (biodegradable and non-biodegradable). Other relevant topics will be covered such as functionalization/bioconjugation of nanobiomaterials (bulk/surface), smart and stimuli-responsive nanobiomaterials, nanometrology, nanotoxicity, and regulation and translation to the clinic. Laboratorial skills will be improved.

Work Placement(s)

No

Syllabus

Theoretical component: introduction to nanobiomaterials; development of nanobiomaterials (current applications, nanostructured materials used in pharmaceutical/biomedical applications; micro-, meso- and macroporous structures; nanostructured surfaces; examples of polymeric, metallic, inorganic, hybrid and composite nanobiomaterials preparation; functionalization/bioconjugation of nanobiomaterials; smart and stimuli-responsive nanobiomaterials;examples of specific applications (pharmaceutical/diagnostic/theranostic applications, and implantable materials/devices - biodegradable/non-biodegradable); nanometrology and nanotoxicity; regulation and translation to the clinic; regulatory frameworks - FDA/EMA; commercialized products - examples).

Head Lecturer(s)

Hermínio José Cipriano de Sousa

Assessment Methods

Assessment
Laboratory work or Field work: 30.0%
Exam: 70.0%

Bibliography

Kee Yi, D., Papaefthymiou, G.C., (Eds.), Nanobiomaterials. Development and Applications, CRC Press, 2014

Wang, X., Ramalingam, M., Kong, X., Zhao, L., (Eds.), Nanobiomaterials. Classification, Fabrication and Biomedical Applications, Wiley-VCH, 2018

Collins, A.M., Nanotechnology Cookbook: Practical, Reliable and Jargon-free Experimental Procedures, Elsevier, 2012

Rao, C.N.R., Muller, A., Cheetham, A.K. (Eds.), The Chemistry of Nanomaterials. Synthesis, Properties and Applications, Wiley-VCH, 2004

Hermanson, G.T., Bioconjugate Techniques, Elsevier, 2013

Webster, T.J. (Ed.), Safety of Nanoparticles. From Manufacturing to Medical Applications, Springer, 2009

Pallotta, A., Clarot, I., Sobocinski, J., Fattal, E., Boudier, A., Nanotechnologies for medical devices: potentialities and risks, ACS Appl. Bio Mater., 2, 1-13, 2019

Min, Y., et al., Clinical Translation of Nanomedicine, Chem. Rev., 115, 11147-11190, 2015