Lectures, Theoretical/Practical and Laboratorial practical during the semester. PowerPoint presentations in lectures. Solving Problems and exercises in the field of Genetics and statistical methods application to Genetics. Scientific papers discussion. Report on a group's work to be presented orally and written. Tutorial support for the report and group's work and also for solving exercises.
This curricular unit has the purpose of providing the student with both theoretical and practical knowledge in the field of genetics.
Specifics skills set:
1. Knowledge and understanding :
Recognize and be able to apply concepts and principles of genetics.
2. Understanding and application of knowledge:
Gather, analyse, syntesize and process information in a pertinent and significant way using the correct laboratorial and mathematical methods and techniques.
3. Decision making:
Conduct himself in the lab in a responsible way to prove the principles of gene transmission. Using the proper tools to calculate probabilities and statisticaly support obtained data.
Process, interpret and communicate current information on the various fields of genetics
5. Self-learning skills:
Become self-sufficient in terms of meta-cognition and self-learning, in areas such as researching scientific literature on current genetic subjects.
1. Introduction to genomic and molecular genetics.
2. DNA structure and DNA manipulation. DNA replication and recombination.
3.Types of DNA markers. Applications on the diagnosis of genetic diseases, in forensic medicine and criminal investigation.
4. Genetic transmission: Mendelism.
5.Genes and chromosomes. Mitosis and meiosis. Chromosomes and hereditarity. Gender determination.
6. Factorial connection and chromosome mapping. Gene distances and recombination frequencies. Chromosomic maps.
7. Molecular mechanisms of DNA mutation and repair. Types of mutation. Molecular basis of mutation.
8.Molecular organization of chromosomes. Bacterial and eukaryotic chromossome structure. Politenic and lampbrush chromosomes. Centromeres and telomeres.
9. Karyotype and chromosome behavior. Chromosomic mutations. Polyploidy.
10. Extranuclear hereditarity. Extranuclear hereditarity patterns. Maternal effect.
11. Population genetics. Gene and allele frequencies. Endogamy. Natural selection.
António Manuel Santos Carriço Portugal
Mini Tests: 10.0%
Laboratory work or Field work: 20.0%
Genetics. Analysis of Genes and Genomes (2009). 7th edition. Daniel L. Hartl & Elizabeth W. Jones. Jones and Bartlett Publishers.
Genetics. Analysis of Genes and Genomes (2012). 8th edition. Daniel L. Hartl & Maryellen Ruvolo. Jones and Bartlett Learning.
Genetic Analysis. An integrated approach (2012). Mark F. Sanders & John L. Bowman. Pearson Education.
Introduction to Genetic Analysis (2008). 8/9th Edition. A. Griffiths, S. Wessler, R. Lewontin & S. B. Carrol. W. H. Freeman and Company.
Genetics. Principles and Analysis (1998). 4th edition. Daniel L. Hartl & Elizabeth W. Jones. Jones and Bartlett Publishers.
Modern Genetic Analysis (1999). 2nd Edition. A. Griffiths, W. Gelbart, J. Miller & R. Lewontin. W. H. Freeman and Company.