Neurobiology and Disease

Recommended Prerequisites

Cellular and Molecular Neurobiology.

Teaching Methods

The teaching methodologies include lectures, classes for discussion of methods used in Cellular and Molecular Neurobiology research, problem solving sessions and presentation and discussion of research papers by the students. The problem solving sessions are aimed at solving problems based on the interpretation of results selected from scientific publications in the field.

Learning Outcomes

The main objective of this course is that the students learn about the alterations responsible for different pathologies of the nervous system related with alterations in development, with neurodegenerative processes or with acute lesions of the nervous system. The different concepts are discussed together with experimental evidences to illustrate key concepts.

Work Placement(s)

No

Syllabus

1. Development of the nervous system

2. Motor neuron diseases

3. Ischemia and Hypoxia

4. Epilepsy

5. Schizophrenia

6. Autism spectrum disorders

7. Parkinson’s disease

8. Neuroinflamation

9. Multiple sclerosis

10. Alzheimer’s disease

11. Protein aggregation in neurodegenerative disorders

12. Polyglutamine disorders

13. Viral vectors for gene therapy

14. Drug development: from bench to marketplace.

Head Lecturer(s)

Carlos Jorge Alves Miranda Bandeira Duarte

Assessment Methods

Assessment
Other: 25.0%
Exam: 75.0%

Bibliography

S.T. Brady, G.J. Siegel, R.W. Albers, D.L. Price (2012) Basic Neurochemistry – Principles of Molecular, Cellular and Medical Neurobiology. Academic Press, Burlington, MA

D. Purves, G.J. Augustine, D. Fitzpatrick, W.C. Hall, A.S. LaMantia, J. McNamara, S.M. Williams (2012) Neuroscience. Sinauer Associates, Inc., MA. (5th edition) 

L. Squire, D. Berg, F.E. Bloom, S. du Lac, A. Ghosh, N.C. Spitzer (2012) Fundamental Neuroscience, 4th edition. Academic Press.

D.H. Sanes, T.A. Reh, W.A. Harris (2012) Development of the Nervous System. Academic Press (3rd edition)

D.J. Price, A.P. Jarman, J.O Mason, P.C. Kind (2011) Building Brains – An Introduction to Neural Development. Wiley-Blackwell.