Biology of Reproduction
2nd Cycle Studies - Mestrado
B.Sc. level training in Biology, Biochemistry or related fields. Or strong basic knowledge (both conceptual and technical) in Biochemistry, Cell and Molecular Biology. English knowledge.
The coursework is modular and intensive, mixing the different class typologies to avoid saturation. Lectures introduce and develop different aspects that will then be explored in both lab exercises, and via the student-oriented analysis and discussion of recent research articles in the field. The goal is to integrate different levels of information and also project what future Masters and PhD-level research Projects might be carried out in the future.
The student should apply previous knowledge in Physiology, Cell, Molecular and Developmental Biology to the specific field of Reproductive Biology, inding endocrinology, gametogenesis and embryogenesis and Assisted Reproduction. Practical lab exercises will include analysis of testicular cells and gametes.
1. Basic Principles of Reproductive Biology
1.1. Behavior and reproductive strategies
1.2. Sexual determination and puberty
1.3. Endocrinological aspects of Reproduction.
2. Gametogenesis, fertilization and early development
2.1. Sexual dimorphism and gametogenesis.
2.2. Fertilization and early development. Epigenetic regulation and 2.3. 2.3. Implantation and placental development
2.4. Embryonic development and birth
2.5. Feeding behavior and post-birth learning
3. Biomedical applications
3.1. Semen quality in mammals. Evaluation at the cell, molecular and biochemical levels.
3.2. Assisted Reproduction and its use in humans.
3.3. Pre and Post-Natal diagnosis
3.4. Pluripotent stem cells as biomedical models
3.5. Bioethical implications.
João Ramalho de Sousa Santos
Laboratory work or Field work: 15.0%
Synthesis work: 25.0%
GILBERT. S, SINAUER (2013). Developmental Biology. 10th edition.
JOHNSON M Wiley-Blackwell (2013). Essential Reproduction. 7th Edition.
Recent Review and relevant Research articles in the field.