Analytical and Imaging Tools in Drug Discovery

Recommended Prerequisites

NA

Teaching Methods

Expositive classes and seminars delivered by specialists with students interaction according to what is expected at the PhD level.

Learning Outcomes

Provides training in instrumentation used to unravel mechanisms of action at molecular and cellular level; additional topics include radiopharmaceuticals, theranostics, photopharmacology, and ultrasound-tissue interactions.

Work Placement(s)

No

Syllabus

The aim of this course is to introduce the students into some of the most used Analytical and Imaging Techniques used today in Drug Discovery. The course is not intensive and does not refer all the possible techniques and tools used. It will provide a basic training to the students in different and complementary techniques such as:

Mass Spectrometry Application in Drug Discovery

NMR/MRI in Drug Discovery

Nuclear Techniques /SPECT and PET in Drug Discovery

X-ray Diffraction in Drug Discovery

Combining Different Techniques in Drug Characterization

Thermal Analysis in Solid Drug Forms.

Head Lecturer(s)

Carlos Frederico de Gusmão Campos Geraldes

Assessment Methods

Assessment
Written report: 100.0%

Bibliography

Facts and fictions about polymorphism, A.J. Cruz-Cabeza, S.M. Reutzel-Edens, J. Bernstein, Chem. Soc. Rev., 44 (2015) 8619-8635.

Crystal Polymorphism in Chemical Process Development, A.Y. Lee, D. Erdemir, A.S. Myerson, Annu. Rev. Chem. Biomol. Eng.,  2  (2011) 259-280.

Pharmaceutical cocrystals: along the path to improved medicines, N. Duggirala, M. L. Perry, O. Almarsson, M. J. Zawarotko, Chem. Comm., 52 (2016) 640-665.

Polymorphism in the Pharmaceutical Industry, R. Hilfiker  (ed.),  Weinheim: Wiley-VCH  (2006).

Pharmaceutical Salts and Co-crystals, J. Wouters, I. Quéré (eds.),  London: Royal Society of Chemistry (2012).

Thermal Analysis of Pharmaceuticals, D.Q.M. Craig, M. Reading (eds), Boca Raton: CRC Press (2007).