Advanced Drug Synthesis

Recommended Prerequisites

Not applicable.

Teaching Methods

Expositive classes and seminars delivered by specialists with students interaction according to what is expected at the PhD level.

Learning Outcomes

Enables the students to plan and evaluate the synthesis of complex drugs and drug-like molecules including the development of ligands for metal based drugs.

Work Placement(s)

No

Syllabus

1. Strategies and planning in organic synthesis

2. Synthesis of Chiral Compounds: Principles and Strategies

3. The Chemistry of Heterocyclic Compounds in Drug Development

4. Catalysis

5. Synthesis of Natural Drugs and Semi-Synthetic Derivatives with Therapeutic Interest.

Head Lecturer(s)

Teresa Margarida Vasconcelos Dias de Pinho e Melo

Assessment Methods

Assessment
Written report: 100.0%

Bibliography

Asymmetric Synthesis, G. Procter, Oxford Science Publications, 1996.

Heterocyclic Chemistry, T. L. Gilchrist, Longman Scientific & Technical, Third Edition, 1997.

Contemporary Drug Synthesis, J. J. Li, D. S. Johnson, D. R. Sliskovic, B. D. Roth, Wiley, 2004.

Strategies for Organic Drug Synthesis and Design, 2º Ed., Daniel Lednicer, Wiley, 2009.

Transition Metals Reagents and Catalysts. Innovations in Organic synthesis - Jiro Tsuji , Wiley, , Chichester, 2002.

Organotransition Metal Chemistry, R.S.C. A.F.Hill, Cambridge 2002.

Organic Chemistry, Jonathan Clayden, Nick Greeves, Stuart Warren, Second Edition, Oxford University Press, 2012.

Organic Synthesis, The Disconnection Approach, Second Edition, Wiley, 2008.

Classics in Total Synthesis, K. C. Nicolau, E. J. Sorensen, VCH, 1996.

Classics in Total Synthesis II, More Targets, Strategies, Methods,  K. C. Nicolau, S. A. Snyder, Wiley-VCH, 2003.

Protective Groups in Organic Synthesis, Fourth Edition, P. G. M. Wuts,, T. W. Greene, Wiley-Interscience, 2007.