Chemical Biology

Recommended Prerequisites

NA

Teaching Methods

Expositive classes and seminars delivered by specialists with students interaction according to what is expected at the PhD level.

Learning Outcomes

Addresses the use of genomic data and chemogenomic approaches in drug discovery, chemical probes to modulate target function, modifications of biomolecules, and ligation chemistries.

Work Placement(s)

No

Syllabus

Introduction to Chemical Biology

Post-translational modifications

Incorporation of unnatural amino acids

Biorthogonal reactions

In vivo Chemistries

Native Chemical Ligation

Development of radioactive probes for imaging and therapy

Activity and affinity-based probes for protein profiling

Fluorescent probes to locate and characterize biomolecules and cellular processes

Design of ADCs

Bioconjugates from the bench to the clinic

Bioconjugates

Inorganic Compounds in Therapy and Diagnostics

Head Lecturer(s)

Maria João Pedrosa Ferreira Moreno Silvestre

Assessment Methods

Assessment
Written report: 100.0%

Bibliography

I. Parolini et al., Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells, J.  BIOL. CHEM.  284, , 34211–34222, 2009

V. P. Torchilin, Fluorescence microscopy to follow the targeting of liposomes and micelles to cells and their intracellular fate, Advanced Drug Delivery Reviews 57, 95 – 109, 2009

D. K. Sasma, Solvation Dynamics of Biological Water in a Single Live Cell under a Confocal Microscope, Langmuir, 29, 2289−2298, 2013.

The Molecular Probes Handbook—A Guide to Fluorescent Probes and Labeling Technologies,

https://www.thermofisher.com/pt/en/home/references/molecular-probes-the-handbook.html