Fundamentals of Medicinal Chemistry

Recommended Prerequisites

Not applicable.

Teaching Methods

Expositive classes and seminars delivered by specialists with students interaction according to what is expected at the PhD level.

Learning Outcomes

Provides a common scientific background and key concepts in drug discovery to all graduate students.

Work Placement(s)

No

Syllabus

1. Administration, biodistribution and fundamental pharmacokinetics

2.Lead validation

3. Drug targets. enzymes, receptors, nucleic acids

4. The prodrug concept - application in drug design. Soft drugs. Drug targeting

5. Hit discovery strategies.

6. Chemical libraries

7. Bridging drug synthesis to biological testing

8. Targets for drug development in ageing and age-related neurodegenerative disorders

9. Metabolism

Head Lecturer(s)

Luís Guilherme da Silva Arnaut Moreira

Assessment Methods

Assessment
Exam: 100.0%

Bibliography

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Eric A. G. Blomme and Yvonne Will, Toxicology Strategies for Drug Discovery: Present and Future, Chem. Res. Toxicol., Article ASAP, Publication Date (Web): November 20, 2015

http://dx.doi.org/10.1021/acs.chemrestox.5b00407

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