Chemical Synthesis

Recommended Prerequisites

Organic Chemistry I and Organic Chemistry II.

Teaching Methods

The teacher should present topics with updated information based on his experience as a researcher. Some scientific studies developed by the teacher can be discussed when they fall in the syllabus content.

A scientific paper will be given and the student will make an oral presentation followed by an oral discussion. In this way the student will be followed more closely. A theme within the subject content of the curricular unit will also be presented on which the student must submit a written review.

Learning Outcomes

The main objective of the Seminars is to give the student the Knowledge and the ability to:

1. Recognize and appling basic concepts and principles in Organic Synthesis

2. Learn to apply acquired knowledge in the individual´s vocational area at the professional approach level.

3. Learn to substantiate arguments when making decisions

4. Understand and know how to use information sources. Ability to search and use bibliography

5. Acquire skills for communicating information clearly, with speech and other appropriate means.

6. Acquire skills in structured presentations of scientific matters to a competent audience, ability to debate, whether orally or in writing.

7. Have skills which enable self-learning throughout life.

Work Placement(s)

No

Syllabus

Strategy and Planing in Organic Synthesis

1. Retrosynthetic Analysis

2. Classic reaction of Formation of carbon-carbon bonds

3. Functional group chemistry

4. Protective Groups

5. Selectivity

6. Stereochemistry

 

The use of organometallic compounds in Organic Synthesis

 

Synthesis of Chiral Compounds: Principles and Strategies. Resolution of enantiomers, The chiral pool, Chiral Auxiliaries, Asymmetric Catalysis

 

Synthesis of Heterocyclic Compounds

Cyclization Reactions (Displacement at saturated carbons, Intramolecular nucleophilic addition to double bonds, cyclization on to triple bonds, Carbene and Nitrene cyclization, Electrocyclic Reactions)

Cycloaddition Reactions (Hetero-Diels-Alder Reactions, 1,3-Dipolar Cycloaddition, Ene Reaction, [2+2] Cycloaddition, Cheletropic Reactions)

Head Lecturer(s)

Teresa Margarida Vasconcelos Dias de Pinho e Melo

Assessment Methods

Assessment
Synthesis work: 25.0%
Exam: 75.0%

Bibliography

Guidebook to Organic Synthesis, R. K. Mackie, D. M. Smith, R. A. Aitken, 3rd Edition, 1999

Advanced Organic Chemistry, Jerry March, 6th Edition, 2007.

Mecanismos de Reacções Orgânicas, Teresa M. V. D. Pinho e Melo, LIDEL-Edições Técnicas, Colecção Química – SPQ, 2005.

Polar Rearrangements, L. M. H. Jarwood, Oxford Chemistry Primers, 1992.

Reactive Intermediates, C. J. Moody and G. H. Whitham, Oxford Chemistry Primers, Oxford Science Publications, 1992.

The Mechanism of Reactions at Transition Metal Sites, R. A. Henderson,  Oxford Chemistry Primers, Oxford Science Publications, 1995.

Heterocyclic Chemistry, T. L. Gilchrist, Longman Scientific & Technical, Third Edition, 1997.

Asymmetric Synthesis, G. Procter, Oxford Science Publications, 1996.