Understanding and use of concepts in chemistry, apply knowledge acquired to solve problems in new situations. Good knowledge of English.
In the curriculum the discipline Bioelectrochemistry corresponds to 6 credit units and a thirteen-week semester, the total number of predicted classes will be 26 lectures and 13 practical classes eaching methods consist of classes: theoretical, theoretical-practical and practical in order to attain the aim global learning
Theoretical evaluation: written questions.
Theoretical-practical and practical evaluation: will be based on a subject chosen from those proposed for a written assay and an oral presentation, and a weekly written question answered on the class.
The objective of the discipline of Bioelectrochemistry is to give to the students the opportunity to obtain knowledge in an area with many applications in chemistry, in particular with regard to the study of mechanisms of electron transfer reactions of compounds of biological interest.
The program objectives are:
1. Emphasize the principles necessary for understanding the nature of the electrode processes and learn the electrochemical techniques necessary and characterize the interfacial region between the electrode and the solution.
2. Study the kinetics and mechanism of electron transfer reactions of compounds biological interest.
3. Describe bioelectroanalytical sensors and their applications in the quantification of different biological compounds.
The extension given to each of these chapters is displayed in the program.
The scope of Bioelectrochemistry. The origin of the electric potential of biomolecules. The electron transfer reactions in biological systems.
Electrochemical cells. The electrochemical interface between biomolecules. Kinetics and mass transport mechanism of the electron transfer reaction.
Electrochemical methods: voltammetric techniques: scanning linear and cyclical, step or impulse, and potentiometric techniques.
Nerve impulse and cardiovascular electrochemistry.
Biocorrosion. Microbial corrosion. Biomaterials. Biocompatibility.
Development of electrochemical biosensors: amperometric or potentiometric for clinical and in vivo implantation, and determination of toxic metal ions and pesticides in biological systems and in the environment.
Electrochemical detectors with applications in HPLC.
Electrochemistry of drugs. Quantification of DNA damage caused by interaction with anticancer drugs using electrochemical methods.
Ana Maria Coelho Ferreira de Oliveira Brett
Synthesis work: 25.0%
Mini Tests: 25.0%
1 - C.M.A. Brett e A.M. Oliveira Brett, Electroquímica. Princípios, Métodos e Aplicações, Livraria Almedina, Coimbra, 1996.
2 - C.M.A. Brett e A.M. Oliveira Brett, Electroanalysis, Oxford University Primers Nº 64, Oxford, 1998.
3 - P.T. Kissinger e W.R. Heineman Ed., Laboratory techniques in electroanalytical chemistry, Dekker, NY, 1996.
4 - A.E.G. Cass, Biosensors. A Practical Approach, IRL Press, OUP, Oxford, 1990.
5 - J.P. Hart, Electroanalysis of Biologically Important Compounds, Ellis Horwood, Chichester, 1990.
6 - Bioelectrochemistry: Fundamentals, Experimental Techniques and Applications, Ed, P.N Bartlett, John Wiley, UK, 2008.