General chemistry; Good english level.
The course will encompass theoretical lectures, T, that will present relevant topics. Selected exercises , TP, will be discussed to apply knowledge in the classroom. Along the semester the student will choose a topic to make a written/oral presentation based on research of literature. Selected search topics will be orally presented to demonstrate the relevance of the programatic items with the real life.
The purpose of the curricular uint is to help students acquire a solid background in structural organic chemistry and characterization. Aims to contribute to the formation of chemists, who wish to integrate pharmaceutical or biotechnology laboratories for research and innovation .
The student must develop :
- Ability to analyze, synthesize and understand the principles of organic synthesis aplied to biomolecules
- Ability to understand the function of both the bioconjugate transport of active ingredients as in diagnosis.
- Ability to solve problems within the area of synthesis of pharmaceuticals and biopolymers.
1. Structure, nomenclature and physical properties of organic compounds
Relation between the unique structural properties of carbon compounds and their physical properties.
2. Stereochemistry of organic compounds
3. Introduction to 1H and 13C NMR
Basic concepts of 1H e 13C RMN for elucidation of the structure of organic compounds
4. Introduction to the reactivity of organic compounds and mechanisms of organic chemical reactions; selected examples of addition, substitution, elimination and condensation reactions.
adição, substituição, eliminação e condensação.
5. Basic concepts of reaction intermediaries and stability
6. Addition reactions to carbon-carbon double and triple bonds
7. Substitution and elimination reactions
SN1, SN2 and E1 and E2 mechanisms
8. Substitution reactions
Subtitution and mechanysm in saturated hydrocarbons; aromatic electrophylic substitution reactions: effect of substituent.
Maria Miguéns Pereira
Mini Tests: 10.0%
Resolution Problems: 10.0%
Synthesis work: 10.0%
VOLLHARDT, K. Peter; SCHORE, Neil E. Organic Chemistry. W. H. Freeman & Co.
CAREY, Francis A. Organic Chemistry. Mc GrawHill.
PINE, Stanley H.; HENDRICKSON, James B.; CRAM, Donald J. Organic Chemistry. Mc Graw Hill.