Cellular Biology of the Human Development

Year
2
Academic year
2020-2021
Code
01003645
Subject Area
Biomedical Sciences
Language of Instruction
Portuguese
Mode of Delivery
Face-to-face
Duration
SEMESTRIAL
ECTS Credits
6.0
Type
Compulsory
Level
1st Cycle Studies

Recommended Prerequisites

Cellular and Molecular Biology; Biochemistry.

Teaching Methods

Traditional lectures, where it is the sole responsibility of the teacher to present general concepts of regulation and control within a cell, a tissue and an organism.

Theoretical and practical lessons in the form of oriented seminars with presentations by students of proposed topics, followed by a period of discussion among students, coordinated by the teacher; these contacts are terminated by a comment and questions from the teacher.

Learning Outcomes

Explain through concepts and technologies common to Cellular and Molecular Biology, Biochemistry and Genetics how the cells develop, propagate, communicate and control their activity. How do they deviate from this pattern of behaviour and what are the clinical consequences of these deviations for cell survival as a unit and the individual as a whole. To apply / choose appropriate technologies to study cellular functions. Integrate knowledge. Present and interpret experimental results and evaluate the possibilities and implications of the diagnoses.

Apply and integrate the knowledge gained in: the understanding of the molecular mechanisms of disease, the interpretation and solution of problems related to such knowledge. Develop the capacity for self-learning, research and information selection.

Work Placement(s)

No

Syllabus

METABOLIC CHARACTERISTICS OF DIFFERENT TISSUES

General organization of cellular metabolism

General principles of metabolism

Major metabolic pathways

Major catabolic pathways

Hierarchy to store and burn energy substrates

General principles of metabolic management at the level of the organism

General principles of metabolic management at the cellular level

General principles of metabolic management at the tissue level

Cellular processes in the hepatocyte and adipocyte

Cellular processes in the neuron and myocyte

CELL COMMUNICATION

Cellular homeostasis

Regulation and control of cellular homeostasis

General principles of cell communication

Revisiting enzyme kinetics

Alosteria and control

Enzymes, engines and decision-makers

Enzyme inhibition

Cell receptors

Second messengers

Integration of signalling cascades

MECHANISMS OF CELL DIFFERENTIATION

Cellular mechanisms of development

Molecular mechanisms of development

Assessment Methods

Assessment
Mini Tests: 30.0%
Report of a seminar or field trip: 30.0%
Exam: 40.0%

Bibliography

Gilbert, S.F. ‘Biologia do Desenvolvimento’, Fundação Calouste Gulbenkian, 2008

Slack, J.M.W. ‘Essential Developmental Biology’ (2nd Ed.),Blackwell, 2006

Koolman, J., Röhm, K.H. ‘Color Atlas of Biochemistry’, Thieme, 1996.

Cunha, R.A. ‘Regulação Bioquímica’, Cap. 17 in ‘Bioquímica – Organização Molecular da Vida’ (Quintas, A., Freire, A.P., Halpern, M.J.), 2009.