Applied Molecular Biology (BMA)

Year
1
Academic year
2018-2019
Code
01011095
Subject Area
Elective Units
Language of Instruction
Portuguese
Mode of Delivery
Face-to-face
ECTS Credits
2.0
Type
Elective
Level
1st Cycle Studies

Recommended Prerequisites

knowledge:

It is taken for granted that the students have a basic knowledge before beginning the study of this curricular unit that is enough to understand its content. This basic knowledge includes, in particular, knowledge in biochemistry and biology.

Skills:

Students should have the ability to read, understand, write and speak English at a level which is enough to understand the recommended bibliography; Ability to use the internet for bibliography research..

Teaching Methods

Learning molecular biology, as in other curricular units, is a multistep process, from acquisition, retention and retrieval of information to the ability to apply that information to new situations. Thus, in this curricular unit these cognitive principles will be applied, using for that purpose an integrated education based on theoretical, theoretical-practical and practical classes and seminars.

Learning Outcomes

It is intended to provide students with the basic knowledge that allows them to acquire and integrate knowledge about the molecular mechanisms of diseases and sensitivity and resistance to therapy, as well as the practical application of different molecular approaches in clinical situations, namely in hematologic, muscular, pneumological, in aging and cancer.

Another objective is to convey to students the importance of interdisciplinarity in molecular diagnostics and its contribution to the development of new therapeutics.

Therefore, students should develop skills and abilities to study problems, recognize their molecular basis, and from then on, take a more rational attitude that allows them to make a diagnosis and apply the most appropriate therapeutics in the course of their future practice as physicians.

Work Placement(s)

No

Syllabus

1. The aim of Molecular Biology in Medicine

2. Major techniques in Molecular Biology – Principles, fundamentals and applications to the study of the mechanisms of disease and drug resistance

3. Cell signaling and Practical applications of the growth factors in hematology: hematopoietic stem cell transplantation

4. The Ribossomopathies and diseases of spliceosome - molecular characteristics, clinical and therapeutic implications

5. Introduction to Molecular Biology of Cancer

      5.1. Cellular and molecular mechanisms involved in the development/progression of cancer and metastasis

      5.2. Molecular mechanisms of sensitivity and resistance to chemotherapy

6. Molecular Biology of  transfusional medicine

7. Molecular biology of  pain,  muscular dystrophies, asthma and pulmonar emphysema

8. Molecular Biology of Aging and Neurological diseases

9. New targeted therapeutic approaches, Recombinant proteins and gene therapy

10. Understanding Pharmacogenetics and Pharmacoepigenomis

Head Lecturer(s)

Ana Bela Sarmento Antunes Cruz Ribeiro

Assessment Methods

Assessment
Frequency: 10.0%
Resolution Problems: 20.0%
Laboratory work or Field work: 20.0%
Mini Tests: 50.0%

Bibliography

Weaver, Robert F. (2008)-  Molecular Biology, 4ª ed. McGraw-Hill.

Epstein, Richard J. (2003)-  Human Molecular Biology :An Introduction to the Molecular Basis of Health and Disease. 1ª ed. Cambridge.

Regateiro, Fernando J. (2003) -Manual de Genética Médica”. 1.ª ed. Imprensa da Universidade de Coimbra.

Ameziane, Nedjima, Bogard, Marc, Lamoril, Jérôme (2006) - Principes de Biologie Moleculaire en Biologie Clinique.Elsevier.

Lodish, Harvey; Berk, Arnold; Kaiser, Chris A. [et.al.] (2008) - Molecular Cell Biology. 6ª ed. W. H. Freeman and Company.

Coleman, William B.; Tsongali, Gregory J. (2009) - Molecular pathology: the molecular basis of human disease. Academic Press.

Runge, MarschallS.; Patterson, Cam (2006)-Principles of Molecular Medicine. Second edition. Totowa, NJ, Humana Press

Cooper , Geoffrey M. (2004) - The Cell: A Molecular Approach.

Artigos científicos e slides das aulas