Biomaterials

Recommended Prerequisites

Not applicable.

Teaching Methods

Participation of students is strongly encouraged during lectures and tutorials, so that students can be agents of their own training process. For lecturing of some specific subjects, experts may be invited. The evaluation is performed by written examinations and presentation of individual works.

Learning Outcomes

This course aims to provide students with knowledge about the state of the art of biomaterials development, with a view to their use in various areas of medicine, with particular emphasis on regenerative medicine applications. Topics such as structural and surface characteristics of biomaterials, relationship between properties and processing techniques, their interaction with surrounding tissues, ethical and regulatory aspects and relevant clinical applications are addressed.

Work Placement(s)

No

Syllabus

Fundamental principles of Biomateriais. Classes of Biomaterials. Physico-chemical and mechanical properties.

Processing technologies. The biomaterial´s market. Clinical applications.

Biomaterials for Regenerative Medicine. Objectives and strategies. Interaction between biomaterials and the host tissue. Mechanisms of biodegradation and surface modifications. Bioceramic, glasses and glass ceramics.

Polymeric materials for use in regenerative medicine and as vehicles for drug delivery. Biometals. Introduction.

Composition, structure and properties. Composites and nanocomposites. Biomimetic approaches to promote multifunctional biomaterials. Degradation and wear. Applicable standards.

3D Biomodelling for the manufacture of custom-made prostheses and implants. Medical models and rapid prototyping techniques. Advantages and applications.

Ethical and regulatory aspects of medical devices. Evaluation of Biocompatibility. Toxicity Regulations applicable to clinical trials.

Assessment Methods

Assessment
Synthesis work: 100.0%

Bibliography

- Biomaterials Science: An Introduction to Materials in Medicine. Eds. B. D. Ratner, A. S. Hoffman, F. J. Schoen, J. E. Lemons, Academic Press, San Diego, (1996);

- Princípios de Ciencia e Engenharia de Materiais, W F Smith, McGraw Hill, (1998)

- J D. Santos “Bonelike® Graft for Regenerative Bone Applications”, Editores: Mark J. Jackson and Waqar Ahmed, Springer, Capítulo 13, do Livro “Surface Engineered Surgical Tools and Medical Devices”, ISBN: 978-0- 387-27026-5, pp 477-512, 2007

- Polymeric Biomaterials. Ed. Severian Dumitriu, Marcel Dekker Inc., New York (2002).

- Hoope, A., Guldal, NS, BBoccaccini, AR, “A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics” Biomaterials, 2011, 32 (11) 2757-74