Heamatology and Imunology

Year
2
Academic year
2024-2025
Code
02020627
Subject Area
Biological and Biomedical Sciences
Language of Instruction
Portuguese
Mode of Delivery
Face-to-face
Duration
SEMESTRIAL
ECTS Credits
5.0
Type
Compulsory
Level
2nd Cycle Studies - Mestrado

Recommended Prerequisites

Cell Biology, Molecular Biology, Biochemistry.

Teaching Methods

Lectures supported by visual material (PowerPoint presentation) with active participation of students through questions that facilitate knowledge correlation.

Practical classes where the students consolidate the theoretical knowledge and develop skills in laboratory procedures and critical analysis of experimental results.

Learning Outcomes

This curricular unit aims to provide students with a basic knowledge of Immunology and Hematology. So, it is intended they will acquire knowledge concerning:

i) Cells and organs of the immune system; ii) Molecular and cellular mechanisms of the innate immune response and of the adaptive immune response; iii) The immune response to infectious diseases; iv) The different types of vaccines; v) The basis of different immunoassays; vi) The blood components and the hematopoiesis;vii) The blood coagulation; viii) Hematological diseases, ix) Hematology Laboratory analysis with special emphasis on the hemogram.

In the end, students are expected to understand:

i) The innate and adaptive immune response; iii) The application of immunochemical techniques; iv) The hematopoietic and hemostasis processes; v) The biochemical and molecular bases of some hematological diseases and the analytical parameters of these diseases.

Work Placement(s)

No

Syllabus

Theoretical

Overview of the immune system (IS).

Cells and organs of the immune system.

Characteristics of the innate IS; executor mechanisms of the innate response

Structure of the antigen recognition receptors on B and T lymphocytes

Antigen presentation in the MHC context

Maturation, activation and differentiation of B and T lymphocytes; Functional features of the adaptive response

Infection and immunity. Vaccines

Hematopoiesis: sites and regulation.

The red blood cell and hemoglobin. Abnormal hemoglobins

Anemias: classification and laboratory data

The hemostasis. The hemostatic system: platelets, coagulation factors, inhibitors and fibrinolysis. Coagulation screening tests

Practical/Laboratory

Structure of the antibody molecule; The antigen-antibody interaction

ELISA assays, Coombs test, cell analysis by flow cytometry

The sample in the hematological analysis

The hemogram. The blood smears

Reticulocyte count. Laboratory tests in the diagnosis of anemia.

Head Lecturer(s)

Armanda Emanuela Castro Santos

Assessment Methods

Continuous Assessment
Alternatively, the students may engage in a periodic evaluation, the first test regarding the theoretical and practical classes of the Immunology component and the second one regarding the theoretical and practical classes of the Hematology component. Students with an overall rating equal to or higher than 10 points (10/20) are considered approved: 50.0%
Written final exam concerning the various components of the course Hematology and Immunology: theoretical and practical/laboratory classes. Students with an overall rating equal to or higher than 10 points (10/20) are considered approved: 50.0%

Bibliography

Kuby Immunology.  Kint, Goldsby and Osborne.  8th Ed., W. H. Freeman and Company, 2018

Fundamentos de Imunologia.  F. A. Arosa E. Cardoso F. Pacheco, 2ª dição, LIDEL, 2012

Hoffbrand's Essential Haematology, V. Hoffbrand, P. Chowdary, G. P. Collins, J. Loke. 9th Ed., Wiley-Blackwell, 2024

Dacie and Lewis Practical Haematology. Barbara J. Bain, Imelda Bates and Michael A. Laffan. 12th ed., Elsevier, 2017.