Heamatology and Imunology

Recommended Prerequisites

 Cellular Biology; Molecular Biology; Biochemistry.

Teaching Methods

Lectures supported by visual material (PowerPoint presentation) with active participation of students through questions and correlation of knowledge.

Practical classes where the students consolidate theoretical knowledge and develop different skills in particular, lab material handling and critical analysis of results.

Learning Outcomes

The course of Haematology and Immunology aims to give students a basic knowledge of Haematology and Immunology. So it is intended that they acquire knowledge on:

i) blood cells, ii) some haematologic diseases, iii) laboratorial analysis, iv) organs and components of the immune system, v) types of immune response, vi) passive and active immunity, vii) different types of vaccines.

Thus, it is expected that, in the end of the course, they realize: i) the importance of blood cells, ii) the biochemical and molecular bases of some hematologic diseases, analytical parameters of those diseases and the associated therapeutic iii) the dynamics and the importance of the immune system, iv) the difference between innate and adaptive immune response, v) the difference between active and passive immune response, vi) advantages and disadvantages of the various types of vaccines.

Work Placement(s)

No

Syllabus

Haematopoiesis and regulation of haematopoiesis

The red blood cell and the haemoglobin. Abnormal haemoglobins

Anaemias. Classification and laboratory data

Haemostasis. The haemostatic system: platelets, coagulation factors, inhibitors and fibrinolysis. Screening tests of blood coagulation

The immune system (IS). IS organs

Functional characteristics of the innate IS; effector mechanisms of the innate response

Structure of antigen recognition receptors on B and T cells; functional features and effector mechanisms of the different antibody classes

Presentation of antigens in the MHC context

Maturation, activation and differentiation of B and T cells; functional characteristics of the adaptive response

The complement system

Infection and Immunity. Vaccine

The sample in haematological analysis. The haemogram and the blood smear

Reticulocyte count. Laboratory tests in the diagnosis of anaemias

The antigen-antibody interaction

Immunogenicity versus antigenicity

Immunochemical assays

Head Lecturer(s)

Teresa Carmo Pimenta Dinis Silva

Assessment Methods

Assessment
Exam: 100.0%

Bibliography

Essential Hematology. A. V. Hoffbrand, P. A. H. Moss and J. E. Pettit. 6thed., Blackwell Publishing , 2011
Practical Hematology. J. Dacie, S. M. Lewis. 10thed., Churchill Livingstone Elsevier, 2006.
Kuby Immunology. Kint, Goldsby and Osborne. 6th ed., W. H. Freeman and Company, 2007
Fundamentos de Imunologia. F. A. Arosa E. Cardoso F. Pacheco, LIDEL, 2012.