Pharmaceutical Chemistry I

Recommended Prerequisites

Organic Chemistry; Biochemistry; General Pharmacology and Pharmacokinetics. 

Teaching Methods

Theorethical Teaching – Expositive lectures, complemented with examples and case-studies.

 Pratical-Lab Classes – Experimental work in laboratory and seminars.     

Learning Outcomes

- To furnish the strategic approaches for the discovery and development of hits, leads and drug candidates.

 -To develop the ability to perform a structure-activity analysis (SAR) to optimize drug  potency and selectivity and to predict their potential for adverse reactios.

- To get critical scientific thinking for decisions on drug development, when integrates in in multidisciplinary research teams.

-To understand the relevance of of  Pharmaceutical Chemistry in drug action, their therapeutic utility and in a rational use drugs.

- To communicate the importance of  Pharmaceutical Chemistry on the professional enrollment, when studying the impact on diseases of preventive and therapeutic attitudes on diseases.  

Work Placement(s)

No

Syllabus

DRUG DISCOVERY, DESIGN AND DEVELOPMENT. DRUG ACTION AT MOLECULAR LEVEL

1.1    Introduction to Pharmaceutical Chemistry

1.2    Drug discovery. Strategies for lead discovery. Case studies

1.3    Drug design and  development. Lead modifications. Case studies

1.4    Drug – receptor interactions. Case studies

1.5    Topography and stereochemistry of drug-receptor complexes. Case studies

1.6    Prodrugs and precursors. Applications. Case studies

1.7    Interactive agents with DNA. Case studies

Practical- Lab Classes

Drug Synthesis and Pharmaceutical Analysis~

For active pharmaceutical ingredients (APIs)

1. Synthesis of aspirin
2. Qualitative and quantitative analysis of aspirin (USP XXIII)
3. Synthesis of  paracetamol
4. Qualitative and quantitative analysis of paracetamol (FP VII)
5. Qualitative and quantitative analysis of procaine chloridrate (USP XX e FP IV)
6. Qualitative and quantitative analysis  of isoniazide (FP VII).

Head Lecturer(s)

Jorge António Ribeiro Salvador

Assessment Methods

Assessment
Laboratory work or Field work: 20.0%
Exam: 80.0%

Bibliography

Silverman R B & Holladay M W,The Organic Chemistry of Drug Design and Drug Action, Academic Press,
3rdEdition, 2014.
-Williams D A and Lemke T L,Foye´s Principles of Medicinal Chemistry, Lippincott Williams &Wilkins, 7thEdition.,
2013.
Wermuth C,The Practice of Medicinal Chemistry, Elsevier, 3rd Ed., 2008.