Biopharmacy and Pharmacokinetics

Recommended Prerequisites

Related knowledge (Pharmaceutical Technology, Pharmacology and Pharmacotherapy); generic skills (analysis and synthesis, information management, problem solving, critical thinking, independent learning, applying theoretical knowledge in practical problem solving and ability to investigate); specific skills (knowing physicochemical mechanisms and kinetics in the present release drugs from dosage forms and comprise the technological variables for modulating the release of drug).

 As the field of linguistic competence Portuguese and English in order to meet the objectives set by the course.

Teaching Methods

Lectures

Expository method, basically slides and videos.

 

Theoretical and practical

Solving problems including determinations of pharmacokinetics parameters  (absortion/distribution / metabolism /excretion) of drugs.

Detailed explanation of the results.

Training for skill in the use of calculation methods commonly employed in order to estimate the pharmacokinetic parameters of different models.

Induction for student participation in scientific like.

 

Evaluation: examination / Exam (100% of the final grade). 

Learning Outcomes

Develop a conceptual model that allows students:

 

•  Know the physical and chemical mechanisms and kinetics present in the drug release from the dosage forms.

•  Understand the technological variables for modulating the release of drugs.

•  Describe routes of administration, physiological and biochemical processes responsible for absorption, distribution, metabolism and excretion of drugs in the body.

•  Quantifying these processes using pharmacokinetic parameters.

•  Adjusting experimental data of plasma concentration "versus" time pharmacokinetic models simplified.

•  Estimate and predict the evolution of the plasma concentration of drugs "versus" time.

•  Apply theoretical concepts to solve practical cases, using the integration of knowledge from courses like (Pharmaceutical Technology, Pharmacology and Pharmacotherapy) 

Work Placement(s)

No

Syllabus

1. Biopharmacy. RADME Series.

2. Drug absorption.

3. Oral administration. Physicochemical factors. Models and parameters. Sublingual route.

4. Parenteral administration. Physicochemical and technological factors.

5. Percutaneous administration. Physicochemical and technological factors.

6. Rectal administration. Physicochemical and technological factors. Genitourinary route.

7. Pulmonary administration route. Release of drugs. Physicochemical and technological factors. Nasal administration.

8. Administration by ophthalmic and auricular route. Physiological constraints that influence absorption. Physicochemical and technological factors.

9. Bioavailability and Bioequivalence. Methodology of bioequivalence studies.

10. Quantification process RADME. Kinetic order of the process.

11. Distribution. Distribution volume. Binding to plasma and tissue proteins.

12. Metabolism.

13. Excretion.

14. Models and pharmacokinetic parameters.

15. Dose calculation. 

Head Lecturer(s)

João Carlos Canotilho Lage

Assessment Methods

Assessment
Exam: 100.0%

Bibliography

BIBLIOGRAFIA GERAL|General bilbiography

PL MADAN,  Biopharmaceutics and Pharmacokinetics, 2^nd edition, Jaypee Brothers Medical Pub., New Delhi. (2014)