Academic year
Subject Area
Biomedical Engineering
Language of Instruction
Other Languages of Instruction
Mode of Delivery
ECTS Credits
2nd Cycle Studies - Mestrado

Recommended Prerequisites

General knowledge of Materials science/biomaterials.

Teaching Methods

The teaching methods aim at developing knowledge in the interdisciplinary aspects of materials engineering and biological systems, fundamental to the field of biocompatibility. Thus, the classes will address topics of fundamental indole with the objective of teaching the fundamental concepts that allow the development of an interdisciplinary approach.The pratical classes will consist in group work that include the preparation and characterization of materials commonly used in biomedicine. In all classes will be encouraged proactive participation by students.

Learning Outcomes

The content of this course provides an introductory overview and critical evaluation to the most relevant aspects related to the Biocompatibility between biological tissues and invasive materials. The approach used is a multidisciplinary prespeective. The goal is to enable students to acquire the theoretical knowledge (basic and specific) that assist them to understand all the multidisciplinary aspects, especially those related with materials engineering/biomedical engineering, involved in the reaction of biological systems to biomaterials. The purpose extends to the development of practical skills through experimental classes.

Work Placement(s)



- Introduction to the course

- Biocompatibility: introduction and definitions; historical evolution of the concept of biocompatibility

- The structural hierarchy in Materials Science and Biology: evolution of the biological response

- The biocompatibility as a function of the binome materials/biological application: specification of the biological target.

- Main properties / characteristics of different types of material to consider in biocompatibility

- Main characterization techniques used in the study of the interface between biological material / biomaterial

- Adverse biological effects: cytotoxicity, sensitivity, irritation, intracutaneous reactivity, systemic and sub chronic toxicity, genotoxicity, hemocompatibility; examples.

- The current paradigm of nano and its effect on the biocompatibility of materials

- Biocompatibility tests: tests matrix of the FDA (Food & Drug Administration) and ISO standards.

Assessment Methods

Continuous assessment
Laboratory work or Field work: 40.0%
Frequency: 60.0%

Final assessment
Exam: 100.0%


J. Park, R.S. Lakes, Biomaterials. An Introduction, 3rd Ed., Springer Science, NY, USA, 2007.

B.D. Ratner, A.S. Hoffman, F.J. Schoen, J.E. Lemons, (Eds.), Biomaterials Science: An Introduction to Materials in Medicine, 2nd Ed., Academic Press, Elsevier, The Netherlands, 2004.

J.B. Park, J.D. Bronzino, (Eds.), Biomaterials. Principles and applications, CRC Press, Boca Raton, FL, USA, 2003.

M. Jenkins (Ed.), Biomedical Polymers, CRC Press, Boca Raton, FL, USA, 2007.

- B.D.Ratner, A.S.Hoffman, F.J.Shoen, J.E.Lemons (eds.) Biomaterials Science: An Introduction to materials in Medicine, Academic press, Elsevier, The Netherlands, 2004.

- J.Black Biological Performance of Materials: Fundamentals of Biocompatibility Mercel Dekker, Inc., New York, USA, 2003.

Bibliografia adicional pode ser fornecida durante as aulas/Additional bibliography can be supplied during classes.