Biocompatibility

Recommended Prerequisites

General knowledge of Materials science/biomaterials

Learning Outcomes

The content of this course provides an introductory overview and critical evaluation to the most relevant aspects related to the Biocompatibility between biological tissues and invasive materials. The approach used is a multidisciplinary prespetiva. The goal is to enable students to acquire the theoretical knowledge (basic and specific) that assist them to understand all the approaches and multidisciplinary aspects, especially those realted with materials engineering, involved in the reaction of biological systems to biomaterials. The purpose extends to the development of practical skills through experimental classes.

Work Placement(s)

No

Syllabus

- Introduction to the course

- Biocompatibility: introduction and definitions; historical evolution of the concept of biocompatibility

- The structural hierarchy in Materials Science and Biology: evolution of the biological response

- The biocompatibility as a function of the binome materials/biological application: specification of the biological target.

- Main properties / characteristics of different types of material to consider in biocompatibility

- Main characterization techniques used in the study of the interface between biological material / biomaterial

- Adverse biological effects: cytotoxicity, sensitivity, irritation, intracutaneous reactivity, systemic and sub chronic toxicity, genotoxicity, hemocompatibility; examples.

- The current paradigm of nano and its effect on the biocompatibility of materials

- Biocompatibility tests: test matrix of the FDA (Food & Drug Administration), standard ISO 10993.

- Final review

Head Lecturer(s)

Ana Paula da Fonseca Piedade

Assessment Methods

Assessment
Exam (100) or midterm exam (60) + research work (40): 100.0%

Bibliography

J. Park, R.S. Lakes, Biomaterials. An Introduction, 3rd Ed., Springer Science, NY, USA, 2007.

B.D. Ratner, A.S. Hoffman, F.J. Schoen, J.E. Lemons, (Eds.), Biomaterials Science: An Introduction to Materials in Medicine, 2nd Ed., Academic Press, Elsevier, The Netherlands, 2004.

J.B. Park, J.D. Bronzino, (Eds.), Biomaterials. Principles and applications, CRC Press, Boca Raton, FL, USA, 2003.

M. Jenkins (Ed.), Biomedical Polymers, CRC Press, Boca Raton, FL, USA, 2007.

- B.D.Ratner, A.S.Hoffman, F.J.Shoen, J.E.Lemons (eds.) Biomaterials Science: An Introduction to materials in Medicine, Academic press, Elsevier, The Netherlands, 2004.

- J.Black Biological Performance of Materials: Fundamentals of Biocompatibility Mercel Dekker, Inc., New York, USA, 2003.

Bibliografia adicional pode ser fornecida durante as aulas/Additional bibliography can be supplied during classes