Clinical Toxicology

Recommended Prerequisites

Basic knowledge in Organic Chemistry; Analytical Chemistry, Molecular Biology, Biochemistry, Human Physiology, Pathology, Clinical Biochemistry, Pharmacology and Toxicology is recommended. Good skills in the English language are also convenient.

Teaching Methods

In the lectures are taught the concepts of the deregulation mechanisms of different organs induced by xenobiotics, trying to integrate this information with guidance for the search and acquisition of knowledge. Students involved in class analyzing case studies that provide acquisition and application of new knowledge.

Laboratory classes facilitate the consolidation of concepts and intend to teach students to be in the laboratory, to think, to identify and solve problems, to present and discuss the results.

Learning Outcomes

The Clinical Toxicology studies, from the standpoint of clinical, analytical and experimental aspects, the human exposure to different toxics, mechanisms of action and their clinical manifestations, methods for their diagnosis. It also discusses the toxicology of drugs, including therapeutic drug monitoring, the adverse effects, drug interactions and individual susceptibility and the development of new drugs, antidoping control and analysis of drugs of abuse.

The main objective is to enable the future Master in Clinical Biosciences acquiring knowledge about the disposition of the various toxic in humans, with particular regard to (i) understand the factors that influence the toxic effects (ii) what types of toxic effects and its mechanisms (iii) know how to analyze changes in biomarkers of different organs to understand the mechanisms of toxicity and to provide the diagnosis (iv) and to acquire knowledge that will be useful in the development of new drugs.

Work Placement(s)

No

Syllabus

Fundamentals of toxicology: An overview. Toxicokinetics;

Toxicodynamics of therapeutic drugs: The pathophysiologic basis of clinical toxicology; The organ system approach and clinical basis of toxicological diagnosis: hematoxicity, hepatotoxicity, nephrotoxicity, cardiotoxicity and its prediction biomarkers.

Mechanisms of mitochondrial toxicity and implications in new therapeutics drugs

Therapeutic drug monitoring and the clinical control of patients: prediction and clinical biomarkers

The Clinical Toxicology in the development of new therapeutic drugs

Analysis of Drugs of Abuse and Anti-doping control

 

Laboratory classes.

Characterization of the molecular mechanisms of action of hemolytic agents:

Evaluation of cytogenotoxic effects of drugs

Curve of plasma concentration versus dose evaluated by HPLC

Mitochondrial mechanisms of hepatic, renal and cardiac toxicity

Prediction Biomarkers of organ injury in clinical toxicology

Antidoping and abuse drugs control: Fluorescence methods.

Head Lecturer(s)

José Barata Antunes Custódio

Assessment Methods

Assessment
Presentation of scientific articles : 10.0%
Laboratory work or Field work: 15.0%
Project: 15.0%
Exam: 60.0%

Bibliography

- Human Toxicology of Chemical Mixtures. Harold I. Zeliger (editor). William Andrew Publishing, 2011.

- CASARETT AND DOULL’S Toxicology: the basic science of poisons. 8th Ed. Curtis D. Klaassen, Editor. USA: McGraw-Hill Companies, 2013.

- Period Journals of Basic & Clinical Pharmacology & Toxicology