Clinical Toxicology

Recommended Prerequisites

Basic knowledge in Organic Chemistry; Analytical Chemistry, Molecular Biology, Biochemistry, Human Physiology, Pathology, Clinical Biochemistry, Pharmacology and Toxicology is recommended. Good skills in the English language are also convenient.

Teaching Methods

The theoretical classes will be taught the concepts more relevant to the different mechanisms of deregulation of different organs induced by xenobiotics, trying to integrate this information with guidance for seeking and acquiring knowledge needed to set goals. Students are encouraged to participate in class analyzing case studies that provide acquisition and application of new knowledge, so classes are affiliated.

The pratical classes illustrate the most relevant programmatic aspects of the theoretical lectures, facilitating the consolidation of concepts and intend to teach students to be in

Learning Outcomes

The Clinical Toxicology studies, from the standpoint of clinical, analytical and experimental aspects, the human exposure to different toxics, mechanisms of their action in the organism and their clinical manifestations, methods for their diagnosis, prevention and treatment, considering all branches of toxicology and relying on other medical disciplines and it is closely linked with the Medical-Legal (Forensic)Toxicology. It also discusses the toxicology of drugs, including therapeutic drug monitoring, the adverse effects, drug interactions and individual susceptibility and the development of new drugs, as well as being drugs of abuse, analysis and antidoping control an important part of Clinical Toxicology.The main objective is to enable the future Master in Clinical Biosciences acquiring knowledge about the disposition of the various toxic in humans, with particular regard to (i) understand the factors that influence the toxic effects (ii)what types of toxic effects and its mechanims

Work Placement(s)

No

Syllabus

Lectures.

1- Fundamentals of toxicology: objectives, historical and definition; toxicology as a multidisciplinary science; basic terminology in toxicology; areas of toxicology and role of the clinical toxicology in medical-legal (forensic) toxicology: An overview.

2- Classification of toxic agents; The biochemical and molecular basis of toxic effects; Toxicokinetics principles.

3- Treatment (general concepts): Removal of toxic substances; Administration of antidotes; Increased elimination of toxic absorbed; Symptomatic treatment (seizure, allergic attack, pain, hyperthermia).

4- Laboratory principles and techniques for evaluation of the poisoned or overdosed patient.

5– The pathophysiologic basis of clinical toxicology: The organ system approach and clinical basis of toxicological diagnosis.

5.1- Blood and hemopoieses changes: Mechanisms of hematoxicity and clinical diagnosis.

5.2- Liver (hepatotoxicity): Changes in liver functions; idiosyncratic liver injury; acute liver failure o

Head Lecturer(s)

José Barata Antunes Custódio

Assessment Methods

Assessment
Exam: 40.0%
Mini Tests: 60.0%

Assessment
Exam: 100.0%

Bibliography

- Clinical Toxicology: Principles and Mechanisms, Frank A. Barile, CRC Press; 2nd edition (2010)

- Human Toxicology of Chemical Mixtures. Harold I. Zeliger (editor). William Andrew Publishing (2008).

- Handbook of Clinical Toxicology, Mary Durrant, HAYLE MEDICAL, (2019).

- Journals of Basic & Clinical Pharmacology & Toxicology