Pharmacology and Pain Therapeutics I

Recommended Prerequisites

Not applicable.

Teaching Methods

Theoretical classes
Final exam 100%.

Learning Outcomes

To know the pharmacology terminology and basic concepts
To Know the different stages of the medicine circuit
To Know the pharmacokinetics and pharmacodynamics of drugs, routes of administration and the main mechanisms of pharmacological action
To know the research methodologies in the field of Pharmacology and specialized sources of information in the field of medicine.

Work Placement(s)

No

Syllabus

Drug characteristics: efficacy, safety profile, route of administration and elimination
Pharmacokinetics and pharmacodynamics
Associations and drug interactions and therapeutic rationality
Research methodologies in experimental pharmacology
Regulation and sources of information
Drug metabolized; CYP system Polymorphism of the CYP system; Metabolized-enzymatic Reactions, phase
II; Metabolism kinetics; Interaction with other medicinal products; Biliary excretion, and enterohepatic
Circulation; Renal Clearance of a Drug;
Central analgesics: narcotics and non-narcotics
"Peripherals” analgesics: analgesics, antipyretic analgesics; non-steroidal anti-inflammatory drugs.
Routes of drug administration; Indications, contraindications and side effects
Side effects of drugs used for the treatment of pain: gastro intestinal, renal, hematological ,etc.

Head Lecturer(s)

Ana Marta Almeida Aveiro Pimentel Lavrador

Assessment Methods

Assessment
Exam: 100.0%

Bibliography

Carneiro AV. COMO AVALIAR A INVESTIGAÇÃO CLÍNICA.
O EXEMPLO DA AVALIAÇÃO CRÍTICA DE UM ENSAIO CLÍNICO. GE - J Port Gastrenterol 2008; 15: 30-36
Bingel U , Tracey I. Effects of pain and placebo on the activation of μ-opioid receptor-mediated
neurotransmission. Physiology 2008;23:371-380
David Moher, Kenneth F. Schulz, Douglas Altman. The CONSORT Statement:Revised Recommendations for
Improving the Quality of Reports of Parallel-Group Randomized Trials. JAMA. 2001;285:1987-1991
Souza Noronha VRA, Gurgel G S, Alves LCF, Ferreira LCN, Mendonça LL, Aguiar EG, Abdo EN. Analgesic
efficacy of Lysine Clonixinate, paracetamol and dipyrone in lower third molar extraction. A randomized
controlled trialMed Oral Patol Oral Cir Bucal. 2009 Aug 1;14 (8):e411-5.
Attal N,Cruccu G, Baron R, Haanpa¨M, Hansson P, Jensen TS, Nurmikko T.
Guidelines on the pharmacological treatment of neuropathic pain: 2010 revisionEuropean Journal of
Neurology 2010, 17: 1113–1123