Neurochemistry and Molecular Biology of Pain

Recommended Prerequisites

Not applicable.

Teaching Methods

Lectures. Presentation and discussion of case studies.
Final written examination-100%.

Learning Outcomes

To acquire up-to-date knowledge of Biochemestry/Neurochemistry and Molecular biology and its application in pain medicine.
To acquire knowledge of the principal techniques used in molecular biology and their applications to the pain medicine, both clinical and research.

Work Placement(s)

No

Syllabus

Cell signalling.
Imaging studies and central pain perception.
Pharmacogenomics of pain therapy approach.
Pathological and physiological role of the endocanabinóde system.
CB1 Receptor, CG2, TRPV1R1.
Epigenetics and the pain. MicroRNAs and pain.
Gene therapy of pain.
Use of stem cells and treatment of pain.

Head Lecturer(s)

Ana Cristina Carvalho Rego

Assessment Methods

Assessment
Exam: 100.0%

Bibliography

Basic Neurochemistry: Molecular, Cellular and Medical Aspects 0-12-088397-X 2006, American Society for Neurochemistry. All rights reserved. Published by Elsevier, Inc
Amy Drendel Pharmacogenomics of Analgesic Agents. Clin Ped Emerg Med 8:262-267

Tracey I. Can neuroimaging studies identify pain endophenotypes in humans. Nat. Rev. Neurol. 7, 173– 181 (2011);
David Juliu, Allan I. Basbaum Molecular mechanisms of nociception. NATURE (2001): VOL 41, 13,
Outra a fornecer.